Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T9205	NCGC00378430	920650-00-6	99.98%
T9205	NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
T3045	Salubrinal	405060-95-9	99.97%
T3045	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T13013	Sodium stibogluconate	16037-91-5	99.95%
T13013	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.
T10486	BCI	1245792-51-1	99.95%
T10486	BCI ((E)-BCI) is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
T2481	Ascomycin	104987-12-4	99.94%
T2481	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T77661	H-NTPDase-IN-4	2939933-09-0	99.92%
T77661	h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM ...
T5708	LUPENONE	1617-70-5	99.92%
T5708	Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhib...
T4671	BN82002	396073-89-5	99.91%
T4671	BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases
T12577	PTP1B-IN-3	809272-64-8	99.91%
T12577	PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
T8519	Raphin1 acetate	2242616-04-0	99.88%
T8519	Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.
T7411	Rbin-1	328023-11-6	99.88%
T7411	Rbin-1 (Ribozinoindole-1) is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
T2144	Tacrolimus	104987-11-3	99.87%
T2144	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosp...
T17235	Voclosporin	515814-01-4	99.85%
T17235	Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephr...
T12080	MLS000544460	352336-36-8	99.84%
T12080	MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM).MLS000544460 exhibits inhibitory effects on Eya2 phosphatas...
T8573	NSC 65809	94023-67-3	99.84%
T8573	NSC-65809 (Raphin1) is a selective inhibitor of R15B.
TN1053	Aloe-emodin-8-O-β-D-glucopyranoside	33037-46-6	99.82%
TN1053	Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in...
T22215	1-Naphthyl phosphate potassium salt	100929-85-9	99.81%
T22215	1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.
T16773	Ro 90-7501	293762-45-5	99.80%
T16773	Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phospho...
T21824	Sephin1	13098-73-2	99.8%
T21824	Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that de...
T3962	TPI-1	79756-69-7	99.79%
T3962	TPI-1 is a SHP-1 inhibitor.