nociceptin receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1071	Nociceptin	Orphanin FQ	Opioid Receptor
	Nociceptin (Orphanin FQ) is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.		Opioid Receptor
TP1793	Nociceptin (1-13), amide		Opioid Receptor
	Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.		Opioid Receptor
T2071	MCOPPB triHydrochloride	MCOPPB trihydrochlride,MCOPPB 3HCl	Opioid Receptor
	MCOPPB triHydrochloride (MCOPPB 3HCl) is a nociceptin receptor agonist.		Opioid Receptor
T28728	SCH-486757
	SCH-486757, a nociceptin receptor (NOP) agonist, is used potentially for the treatment of cough.
T23076L	Nociceptin (1-7) acetate		Opioid Receptor
	Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity.		Opioid Receptor
TP1885L1	[(pF)Phe4]Nociceptin(1-13)NH2 acetate		Opioid Receptor
	[(pF)Phe4]Nociceptin(1-13)NH2 acetate is a selective agonist of NOP receptor with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 acetate displays high selectivity over δ, κ, and μ opioid receptors (>30...		Opioid Receptor
TP1793L	Nociceptin (1-13) amide TFA		Opioid Receptor
	Nociceptin (1-13), amide is a potent agonist Opioid receptor-like1 (ORL1) receptor with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.		Opioid Receptor
TP1941L1	Ac-RYYRWK-NH2 acetate		Opioid Receptor
	Ac-RYYRWK-NH2 acetate is a potent partial agonist of the nociceptin receptor(NOP), which is the endogenous ORL1 receptor agonist.		Opioid Receptor
TP1882L1	Orphanin FQ(1-11) acetate(178249-41-7 free base)		Opioid Receptor
	Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays a...		Opioid Receptor
T15799	LY2940094	LY-2940094	Opioid Receptor
	LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot...		Opioid Receptor
T24831	SR8993	SR 8993,SR-8993
	SR8993 is a highly selective, brain-penetrant agonist of the nociceptin receptor.
T27939	LY2940094 tartrate	LY2940094,LY 2940094,LY-2940094 tartrate,LY-2940094
	LY-2940094, a nociceptin receptor antagonist, is used potentially for the treatment of major depressive disorder and alcoholism.
T23475	Trap-101 hydrochloride	Trap 101	Others
	nociceptin/orphanin FQ (NOP) receptor antagonist		Others
T75908	Nociceptin(1-7) TFA
	Nociceptin (1-7) TFA, the N-terminal bioactive fragment of nociceptin, serves as a potent ORL 1 (NOP) receptor agonist, exhibiting antinociceptive properties. Its combination with nociceptin effectively reduces hyperalge...
TP1987	[Nphe1]Nociceptin(1-13)NH2
	Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitr...
T26918	BU08028	BU 08028,BU-08028
	BU08028 is a mu opioid peptide (MOP) receptor and nociceptin-orphanin FQ peptide (NOP) receptor agonist.
TP1988	[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
	Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum a...
T75909	[Nphe1]Nociceptin(1-13)NH2 TFA
	[Nphe1]Nociceptin(1-13)NH2 is a novel endogenous ligand for the nociceptin/orphanin FQ (NC) receptor, acting as a selective and competitive antagonist without any agonist effects. It binds specifically to recombinant noc...
T12120	MT-7716 hydrochloride	W-212393 hydrochloride	Others
	MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)		Others
T26673	AT-076	AT 076
	AT-076 is a noncompetitive antagonist of the κ-opioid receptor (Ki = 1.14 nM) and nociceptin receptor (Ki = 1.75 nM) and a competitive antagonist of the μ-opioid receptor (Ki = 1.67 nM) and δ-opioid receptor (Ki = 19.6 n...
T76420	Nocistatin
	Nocistatin, an endogenous neuropeptide, serves as a ligand for the orphan opioid receptor-like receptor and functionally antagonizes the neuropeptide nociceptin/orphanin FQ (Noc/OFQ). It inhibits 5-HT release through a G...
T75906	Nociceptin (1-13), amide TFA
	Nociceptin (1-13), amide TFA, a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist, exhibits a pEC 50 of 7.9 in mouse vas deferens and a K i of 0.75 nM for rat forebrain membrane binding [1] [2].
T83685	UFP101 TFA
	UFP101 is a synthetic peptide that functions as an antagonist of the nociceptin receptor, demonstrating high affinity with a Ki of 0.06 nM in CHO cells expressing the human receptor. It exhibits selectivity for the nocic...
T21345	MCOPPB
	MCOPPB is a potent and selective agonist for the nociceptin receptor with a pKi of 10.07, much weaker activity at other opioid receptors. In animal studies, MCOPPB produces potent anxiolytic effects, with no inhibition o...
T21999	(±)-J 113397
	(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM). J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC 50...
T75896	[Arg14,Lys15]Nociceptin TFA
	[Arg14,Lys15]Nociceptin TFA is a potent and selective agonist for the NOP receptor (ORL1; OP4), exhibiting an EC50 of 1 nM. It demonstrates significant selectivity against opioid receptors, with IC50 values of 0.32 nM fo...
T12120L	MT-7716 free base	W-212393	Others
	MT-7716 free base is a selective non-peptide agonist of nociceptin receptor (NOP). It is used for promising potential treatment drugs for alcohol abuse and relapse prevention.		Others
T40510	Ac-RYYRWK-NH2 TFA	Ac-RYYRWK-NH2 TFA
	Ac-RYYRWK-NH2 is a highly effective and specific partial agonist for the nociceptin receptor (NOP). It demonstrates a remarkable affinity for rat cortical membranes ORL1, with [3H]Ac-RYYRWK-NH2 exhibiting a Kd value of 0...
TP1885	[(pF)Phe4]Nociceptin(1-13)NH2
	Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronocicep...
TP2105	UFP-101
	Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pKi = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and op...
TP1882	Orphanin FQ(1-11)	Orphanin FQ (1-11)
	Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays a...
T62805	SB-612111 hydrochloride
	SB-612111 hydrochloride is a potent, novel orphan receptor for opioid receptors (ORL-1) antagonist with high affinity for hORL-1 and a Ki value of 0.33 nM. SB-612111 hydrochloride is able to act on mu-receptor (Ki: 57.6 ...
T36376	SB-612111
	SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6...
T75897	Orphanin FQ(1-11) TFA
	Orphanin FQ(1-11) TFA, a fragment of orphanin FQ or nociceptin (OFQ/N), acts as a powerful NOP receptor (ORL-1; OP4) agonist, exhibiting a K i of 55 nM. It lacks affinity for μ, δ, κ1, and κ3 receptors (K i >1000 nM), de...
TP1986	[Arg14,Lys15]Nociceptin
	Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasti...
T83709	LIH383 TFA	Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2
	LIH383 is a peptide agonist specifically designed to activate the chemokine (C-X-C motif) receptor 7 (CXCR7), which functions both as a chemokine and an opioid peptide scavenger receptor. Demonstrating a high selectivity...