NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat No.	product name
T0020	Sodium 4-aminosalicylate dihydrate	Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate ...
T0122	Bengenin	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T0167	Vinpocetine	Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0307	Tyloxapol	Tyloxapol is a non-ionic liquid polymer used as a surfactant.
T0335	Sodium salicylate	Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T0429	Glucosamine	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
T0607	Dihydroartemisinin	Dihydroartemisinin is a metabolite of artemisinin.
T0646	Mesalamine	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0694	Pranlukast	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
T0907	Sulfasalazine	Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T10318	Anatabine dicitrate	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amylo...
T10383	Asatone	Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, J...
T10981	DCZ0415	DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can im...
T11018	DHMEQ racemate	DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
T11060	DMAPT	DMAPT (Dimethylamino Parthenol) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor. For cell populations in AML cells, t...
T12828	Salicortin	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activit...
T12942	SN50	SN50 is a cell permeable NF-κB translocation inhibitor.
T1296	Aminopar	Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T12975	Sootepin D	Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
T1301	Guaiacol	Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anest...
T13265	Urolithin B	Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enh...
T13604	CDDO-dhTFEA	CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It resto...
T13625	Coronalolic acid	Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
T13686	Ergolide	Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB. Ergolide is a s...
T14491	B022	B022 is an inhibitor of NF-κB-inducing kinase (NIK) (Ki: 4.2 nM). B022 protects liver from oxidative stress, toxin-induced inflammation, and injury.
T15198	Edasalonexent	Edasalonexent is an orally bioavailable inhibitor of NF-κB.
T15601	IT-901	IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). I...
T16290	NIK SMI1	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
T16344	NS-2028	NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). NS-2028 is commonly...
T16706	Quinoclamine	Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
T16974	TAK-243	TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as...
T17157	TRAF-STOP inhibitor 6877002	TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activa...
T17252	WAY-204688	WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAEC...
T17309	(R)-(-)-Ibuprofen	(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.
T1930	JSH23	JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.
T2140	Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T2759	Loganin	Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
T2768	Saikosaponin A	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inﬂammatory, immunomodulatory, and ant...
T2777	Ginsenoside Rg1	Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and i...
T2794	Astilbin	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.