| T9582 |
CLEFMA |
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
|
|
| TQ0169 |
Inulicin |
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
|
|
| TN1104 |
Cyanidin-3-O-sambubioside chloride |
Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
|
|
| TN1094 |
Ginsenoside Rg6 |
Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells
|
|
| TN1079 |
Deoxyelephantopin |
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK,...
|
|
| TN1051 |
1-Caffeoylquinic acid |
1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
|
|
| TN1035 |
Irisolidone |
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
|
|
| TN1016 |
Kukoamine A |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = ...
|
|
| TN1009 |
Epimagnolin B |
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
|
|
| T7889 |
C25-140 |
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
|
|
| T4S1540 |
Myrislignan |
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
|
|
| T3860 |
Isoliquiritin apioside |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
|
|
| T7980 |
Hesperidin methylchalcone |
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
|
|
| T7511 |
Cyclo(his-pro) |
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathw...
|
|
| TQ0305 |
CID-2858522 |
CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
|
|
| TQ0185 |
14-Deoxy-11,12-didehydroandrographolide |
14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
|
|
| TQ0131 |
Rocaglamide |
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...
|
|
| TN1117 |
Veraguensin |
Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity.
|
|
| T5798 |
Euphorbiafactor L2 |
Euphorbiafactor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
|
|
| T4S1615 |
Sanggenone C |
1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome fu...
|
|
| T5S1632 |
8-O-Acetylshanzhiside methyl ester |
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
|
|
| T5S2228 |
6'''-Feruloylspinosin |
6'''-Feruloylspinosin may possess anti-inflammatory activity.
|
|
| T5558 |
Chelidonic acid |
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
|
|
| T5660 |
Menthone |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
|
|
| T5687 |
WITHAFERIN A |
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
|
|
| T5754 |
Kavain |
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of tran...
|
|
| TQ0073 |
Andropanolide |
Andrographolide is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. It is a natural product mainly produced from the pl...
|
|
| T5773 |
5-hydroxy-7,8-dimethoxyflavone |
5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
|
|
| T5727 |
CAFESTOL |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
|
|
| T5769 |
Stachydrine |
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
|
|
| T5764 |
Alliin |
Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which s...
|
|
| T5814 |
Aurantiamide |
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
|
|
| T7283 |
Sodium lauroyl-α-hydroxyethyl sulfonate |
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
|
|
| TN1116 |
Schisandrone |
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
|
|
| TN1126 |
Sakuranetin |
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
|
|
| T6S1101 |
Astragalin |
1. Astragalin may be a potential agent in the treatment of osteoarthritis. 2. Astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inh...
|
|
| TN1691 |
Glabrol |
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
|
|
| TN1576 |
Diallyl disulfide |
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
|
|
| TN1598 |
Dunnianol |
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
|
|
| TN1620 |
Eriocalyxin B |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
|
|
| TN1637 |
Eurycomalactone |
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits prot...
|
|
| TN1660 |
Ganoderic acid C1 |
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ...
|
|
| TN1664 |
Ganoderic acid H |
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in t...
|
|
| TN1764 |
Incensole acetate |
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
|
|
| TN1525 |
Convallatoxin |
Convallatoxin is a natural product.
|
|
| TN1786 |
Isomeranzin |
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
|
|
| TN1793 |
Isorhamnetin 3-O-galactoside |
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
|
|
| TN1806 |
Isotetrandrine |
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
|
|
| TN1828 |
Kahweol |
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
|
|
| TN1832 |
Kanzonol C |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
|
|
| TN1833 |
Karacoline |
Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathwa...
|
|
| TN1562 |
Dehydromiltirone |
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
|
|
| TN1504 |
Citreorosein |
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
|
|
| TN1131 |
Handelin |
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
|
|
| TN1347 |
8-Prenylkaempferol |
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
|
|
| TN1141 |
Isodeoxyelephantopin |
Isodeoxyelephantopin can inhibit the growth of various tumor cells.
|
|
| TN1143 |
1-O-Acetyl britannilactone |
1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
|
|
| TN1182 |
11-Keto-beta-boswellic acid |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
|
|
| TN1212 |
2-Hydroxyeupatolide |
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and ...
|
|
| TN1237 |
3,4-Dihydroxy-5-methoxybenzoic acid |
3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
|
|
| TN1341 |
8-Deoxygartanin |
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it ha...
|
|
| TN1359 |
Aflatoxin G1 |
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
|
|
| TN1493 |
Chrysosplenol D |
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
|
|
| TN1379 |
Alphitolic acid |
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
|
|
| TN1410 |
Asperulosidic acid |
Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and ...
|
|
| TN1448 |
(-)-Bornyl acetate |
(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl ...
|
|
| TN1466 |
Canthin-6-one |
Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflamm...
|
|
| TN1484 |
Cheilanthifoline |
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation ...
|
|
| TN1485 |
Chicanine |
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
|
|
| T6S1141 |
Ganoderic acid A |
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
|
|
| T6S1256 |
Ruscogenin |
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
|
|
| TN1846 |
Kushenol W |
Kushenol W is a natural product
|
|
| T3662 |
Eleutheroside E |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus...
|
|
| T6204 |
QNZ |
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
|
|
| T0335 |
Sodium salicylate |
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
|
|
| T3000 |
Magnolol |
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
|
|
| T2878 |
Ginsenoside Rd |
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
|
|
| T3384 |
Wedelolactone |
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
|
|
| T2872 |
Ginsenoside Re |
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
|
|
| T3147 |
Pyrrolidinedithiocarbamate ammonium |
Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
|
|
| T2992 |
Pinocembrin |
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
|
|
| T3416 |
Aucubin |
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
|
|
| T0122 |
Bengenin |
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
|
|
| T3012 |
Mangiferin |
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
|
|
| T0167 |
Vinpocetine |
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
|
|
| T2822 |
Ginsenoside Rb1 |
Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
|
|
| T3251 |
Stachydrine Hydrochloride |
Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.
|
|
| T0429 |
Glucosamine |
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
|
|
| T3668 |
Galangin |
Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
|
|
| T2768 |
Saikosaponin A |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inflammatory, immunomodulatory, and anti...
|
|
| T6429 |
Caffeic Acid Phenethyl Ester |
Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways,...
|
|
| T6718 |
Vanillylacetone |
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrh...
|
|
| T3954 |
Adelmidrol |
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
|
|
| T3603 |
Sodium lauryl sulfoacetate |
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
|
|
| T2759 |
Loganin |
Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent...
|
|
| T2140 |
Parthenolide |
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
|
|
| T3913 |
Saikosaponin D |
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
|
|
| T2794 |
Astilbin |
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
|
|
| T2777 |
Ginsenoside Rg1 |
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
|
|
| T3627 |
IQ-1S |
IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cart...
|
|
| T0307 |
Tyloxapol |
Tyloxapol is a non-ionic liquid polymer used as a surfactant.
|
|
| T3816 |
Velutin |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well a...
|
|
| T3427 |
Polydatin |
Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and el...
|
|
| T3332 |
Isosteviol |
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
|
|
| T3862 |
Irigenin |
Irigenin has antifungal activity.
|
|
| T2898 |
Andrographolide |
Andrographolide(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic....
|
|
| T5S1607 |
Morusin |
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopt...
|
|
| T5S1097 |
Neferine |
1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be help...
|
|
| T6661 |
SC75741 |
SC75741 is a potent P65 inhibitor with IC50 of 200 nM
|
|
| T4361 |
CBL0137 hydrochloride |
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperon...
|
|
| T4126 |
CBL0137 |
CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromat...
|
|
| T3S0335 |
Soyasaponin Bb |
1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
|
|
| T4S1050 |
Pristimerin |
1. Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the rev...
|
|
| T4518 |
Licochalcone D |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
|
|
| T3S0737 |
NSC 37445 |
1. NSC 37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle...
|
|
| T0646 |
Mesalamine |
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
|
|
| T6S1495 |
Ginsenoside Rk3 |
1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
|
|
| T4S1962 |
Beta-Asarone |
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
|
|
| T3S0738 |
Yangonin |
1. Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the in...
|
|
| T4S0878 |
Prunetin |
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
|
|
| T4S2063 |
Tetrahydrocoptisine |
1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
|
|
| TWS1977 |
Kamebakaurine |
1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
|
|
| T1301 |
Guaiacol |
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
|
|
| T3826 |
Polygalasaponin F |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and r...
|
|
| T2913 |
Schisantherin A |
Schisantherin A is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent....
|
|
| T1296 |
Aminopar |
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
|
|
| T0907 |
Sulfasalazine |
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
|
|
| T0020 |
Sodium 4-aminosalicylate dihydrate |
Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate s...
|
|
| T2921 |
Sinomenine hydrochloride |
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
|
|
| T3892 |
Isoacteoside |
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
|
|
| T2930 |
α-Lipoic Acid |
α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-L...
|
|
| T6677 |
Sophocarpine |
Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast forma...
|
|
| T3877 |
Esculentoside A |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. ...
|
|
| T3729 |
Ethyl gallate |
Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependen...
|
|
| T3918 |
Ginsenoside Rb3 |
Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction ...
|
|
| T2947 |
Indole-3-carbinol |
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
|
|
| T3406 |
Kuromanin chloride |
Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
|
|
| T0607 |
Dihydroartemisinin |
Dihydroartemisinin is a metabolite of artemisinin.
|
|
| T1930 |
JSH23 |
JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.
|
|
| T3893 |
Forsythoside B |
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response a...
|
|
| TN1834 |
Kobusin |
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
|
|
| TN1866 |
Licoricesaponin G2 |
Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
|
|
| T21577 |
Narasin (sodium salt) |
Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by s...
|
|
| TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
|
|
| TN4399 |
Kushenol C |
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
|
|
| TN4394 |
Kobophenol A |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
|
|
| TN4383 |
Kazinol U |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
|
|
| TN4374 |
Kaerophyllin |
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
|
|
| TN4315 |
Isonardosinone |
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
|
|
| TN4286 |
Isodunnianol |
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
|
|
| TN4271 |
Isochamaejasmine |
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
|
|
| TN4263 |
Isoangustone A |
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
|
|
| TMA1890 |
Icariside F2 |
Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects...
|
|
| TN4234 |
Hydrangenol |
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
|
|
| TMA1777 |
Hydrangenol 8-O-glucoside |
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
|
|
| TN4213 |
Hirsutenone |
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
|
|
| TN4194 |
Heliangin |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
|
|
| TN4171 |
Grossamide |
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
|
|
| TN4094 |
Gallocatechin gallate |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
|
|
| TN4437 |
Licorisoflavan A |
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
|
|
| TN3709 |
Coronarin D ethyl ether |
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis....
|
|
| TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
|
|
| TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
|
|
| TN3614 |
Cearoin |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
|
|
| TN3620 |
Celaphanol A |
Celaphanol A shows moderate inhibition in both NF-κB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway...
|
|
| TN3635 |
Chlojaponilactone B |
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
|
|
| TN3708 |
Coronarin D |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
|
|
| TN3802 |
Dehydrodiconiferyl alcohol |
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
|
|
| TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
|
|
| TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
|
|
| TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
|
|
| TN3922 |
Effusanin E |
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
|
|
| TN3931 |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
|
|
| TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
|
|
| TN4046 |
Excisanin A |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
|
|
| TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
|
|
| TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
|
|
| TN3537 |
Braylin |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
|
|
| T25150 |
BI-69A11 |
BI-69A11 is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt...
|
|
| TN5250 |
Vomifoliol |
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
|
|
| TN5284 |
Sodium Houttuyfonate |
Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...
|
|
| T23861 |
CAY10526 |
CAY10526 is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
|
|
| T8981 |
WAY-169916 |
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estr...
|
|
| T9033 |
MDK6620 |
MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and redu...
|
|
| TN6726 |
Methyl chlorogenate |
Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
|
|
| T27012 |
Chrysotoxine |
Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
|
|
| TMA0507 |
Tomatidine |
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
|
|
| T9105 |
NF-κB-IN-1 |
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. ...
|
|
| TN6730 |
Epoxyazadiradione |
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
|
|
| T12942L |
SN50 acetate (213546-53-3 free base) |
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
|
|
| TP1615L |
IKKγ NBD Inhibitory Peptide acetate |
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region. IKKγ ...
|
|
| T21480 |
Diethylmaleate |
Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
|
|
| T22115 |
NF-κB Activation Inhibitor III |
The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.
|
|
| TN5153 |
Torilin |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
|
|
| TN5149 |
Tirotundin |
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activ...
|
|
| TN4490 |
Manassantin B |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
|
|
| TN4683 |
Nyasol |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
|
|
| TN4604 |
Myricanone |
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
|
|
| TN4633 |
Neocryptotanshinone II |
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
|
|
| TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
|
|
| TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
|
|
| TN4652 |
Niazimicin |
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
|
|
| TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
|
|
| TN4774 |
Physalin A |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
|
|
| TN5138 |
Teuclatriol |
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
|
|
| TN4785 |
Picrasidine I |
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gen...
|
|
| TN4938 |
Samidin |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
|
|
| TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
|
|
| TN4956 |
Scandoside |
Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidati...
|
|
| TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
|
|
| TN5019 |
Siegeskaurolic acid |
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
|
|
| TN3539 |
Broussonin A |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
|
|
| TN3517 |
Bisacurone |
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
|
|
| TN1923 |
Mesaconine |
Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation an...
|
|
| T14491 |
B022 |
B022 is an inhibitor of NF-κB-inducing kinase (NIK) (Ki: 4.2 nM). B022 protects liver from oxidative stress, toxin-induced inflammation, and injury.
|
|
| TN2309 |
Withanolide A |
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
|
|
| TN2327 |
Zedoarondiol |
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
|
|
| T10981 |
DCZ0415 |
DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can imp...
|
|
| T11018 |
DHMEQ racemate |
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
|
|
| T11060 |
DMAPT |
DMAPT is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells....
|
|
| T11096 |
DRI-C21045 |
Dri-c21045 showed concentration-dependent inhibition of NF-kB activation and all CD40L induced by B cell proliferation with IC50 of 17.1 μM and 4.5 μM, respect...
|
|
| T10318 |
Anatabine dicitrate |
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloi...
|
|
| TN2217 |
Sophoflavescenol |
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
|
|
| T10383 |
Asatone |
Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JN...
|
|
| T15198 |
Edasalonexent |
Edasalonexent is an orally bioavailable inhibitor of NF-κB.
|
|
| T12828 |
Salicortin |
Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity...
|
|
| T12942 |
SN50 |
SN50 is a cell permeable NF-κB translocation inhibitor.
|
|
| T12975 |
Sootepin D |
Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
|
|
| T13686 |
Ergolide |
Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB. Ergolide is a se...
|
|
| TN2232 |
Soyasaponin Ab |
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
|
|
| TN2179 |
Saponarin |
Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
|
|
| T13604 |
CDDO-dhTFEA |
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restor...
|
|
| TN2079 |
(-)-Pinoresinol |
Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulati...
|
|
| TN1933 |
Mitraphylline |
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
|
|
| TN1953 |
Morusinol |
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
|
|
| TN1960 |
Mussaenoside |
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
|
|
| TN2008 |
Okanin |
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
|
|
| TN2062 |
Phyllanthin |
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
|
|
| TN2075 |
Pimaric acid |
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
|
|
| TN2080 |
Pinoresinol |
Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric...
|
|
| TN2178 |
Sanggenone H |
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
|
|
| TN2089 |
Platycodin D3 |
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway ...
|
|
| TN2095 |
Pomiferin |
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
|
|
| TN2163 |
Rubioncolin C |
Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM.
|
|
| TN2164 |
Rubipodanone A |
Rubipodanone A is a natural product
|
|
| TN2165 |
Rubrofusarin-6-O-beta-D-gentiobioside |
Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it...
|
|
| TN2177 |
Sanggenol L |
Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
|
|
| T13265 |
Urolithin B |
Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
|
|
| T15601 |
IT-901 |
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT...
|
|
| TN3486 |
Bakkenolide IIIa |
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
|
|
| TN3119 |
5-Hydroxy-7,8-dimethoxyflavanone |
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
|
|
| TN2546 |
1-Isomangostin |
1-Isomangostin has cytotoxic, and anticomplement activities.
|
|
| TN2588 |
11-Hydroxytephrosin |
11-Hydroxytephrosin inhibits NF-kappaB activity.
|
|
| TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
|
|
| TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
|
|
| TN3049 |
4-Methoxycinnamyl alcohol |
4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
|
|
| TN3070 |
4beta-Hydroxywithanolide E |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
|
|
| TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone |
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
|
|
| TN2451 |
Isosalvianolic acid B |
Isosalvianolic acid B is a natural from Salviae miltiorrhizae
|
|
| TN3209 |
7,3',4'-Trihydroxyflavone |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
|
|
| TN3219 |
7,8-Didehydrocimigenol |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
|
|
| TN3298 |
8alpha-Hydroxyhirsutinolide |
8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
|
|
| TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
|
|
| TN3397 |
Alpinumisoflavone |
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
|
|
| TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
|
|
| TN2539 |
1beta-Hydroxyalantolactone |
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
|
|
| TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
|
|
| T13625 |
Coronalolic acid |
Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
|
|
| T17252 |
WAY-204688 |
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT...
|
|
| T16290 |
NIK SMI1 |
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
|
|
| T16324 |
Nimbolide |
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
|
|
| T16706 |
Quinoclamine |
Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
|
|
| T16974 |
TAK-243 |
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
|
|
| T17157 |
TRAF-STOP inhibitor 6877002 |
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activat...
|
|
| T17217 |
Vamorolone |
Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
|
|
| T17309 |
(R)-(-)-Ibuprofen |
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.
|
|
| T5S0993 |
Kurarinone |
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
|
|
| T2S1040 |
Jolkinolide B |
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
|
|
| T3S0209 |
Vincristine |
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
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| T3S1692 |
Octahydrocurcumin |
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
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| T3S1707 |
Dendrophenol |
Dendrophenol is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.
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| T4237 |
Rubiadin 1-methyl ether |
Rubiadin 1-methyl ether is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of ...
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| T4366 |
Quinovic acid |
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
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| T0694 |
Pranlukast |
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
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