NF-κB

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T0020	Sodium 4-aminosalicylate dihydrate	Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate ...
T0122	Bengenin	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T0167	Vinpocetine	Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0307	Tyloxapol	Tyloxapol is a non-ionic liquid polymer used as a surfactant.
T0335	Sodium salicylate	Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T0429	Glucosamine	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
T0646	Mesalamine	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0694	Pranlukast	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
T0875	Acetylcysteine	Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
T0907	Sulfasalazine	Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T1296	Aminopar	Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T1930	JSH-23	JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）,suppresses the transcriptional activity.
T2140	Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T2759	Loganin	Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed poten...
T2768	Saikosaponin A	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-...
T2898	Andrographolide	Andrographolide(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic...
T2921	Sinomenine hydrochloride	Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
T2947	Indole-3-carbinol	Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T2992	Pinocembrin	Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
T3000	Magnolol	Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3147	Pyrrolidinedithiocarbamate ammonium	Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
T3332	Isosteviol	Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
T3384	Wedelolactone	Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T3406	Kuromanin chloride	Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
T3416	Aucubin	Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T3427	Polydatin	Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and e...
T3603	Sodium houttuyfonate	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T3662	Eleutheroside E	Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannu...
T3668	Galangin	Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T3729	Ethyl gallate	Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-depende...
T3816	Velutin	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well ...
T3826	Polygalasaponin F	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and ...
T3862	Irigenin	Irigenin has antifungal activity.
T3877	Esculentoside A	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways....
T3892	Isoacteoside	Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular s...
T3893	Forsythoside B	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response ...
T3913	Saikosaponin D	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T3S0335	Soyasaponin Bb	1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-...
T3S0737	Flavokawain A	1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-m...
T3S0738	yangonin	1. Yangonin exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent p...
T4361	CBL0137 hydrochloride	CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chapero...
T4S0878	Prunetin	1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-o...
T4S1050	Pristimerin	1. Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the r...
T4S1615	Sanggenone C	1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome f...
T4S1962	beta-Asarone	1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in ...
T4S2063	Tetrahydrocoptisine	1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhib...
T5S1607	Morusin	1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apop...
T5S1632	8-O-Acetylshanzhiside methyl ester	8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
T5S2228	6'''-Feruloylspinosin	6'''-Feruloylspinosin may possess anti-inflammatory activity.
T6204	QNZ	QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

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