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NF-Κb NF-κB

NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat No. product name
T12942L SN50 acetate (213546-53-3 free base) SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
T7283 Sodium lauroyl-α-hydroxyethyl sulfonate Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
TN1035 Irisolidone Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
TN1016 Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
TN1009 Epimagnolin B Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T7889 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T4S1540 Myrislignan Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
T3860 Isoliquiritin apioside Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
T7980 Hesperidin methylchalcone Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
T7511 Cyclo(his-pro) Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathw...
TQ0305 CID-2858522 CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
TQ0185 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
TQ0169 Inulicin Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
TQ0131 Rocaglamide Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...
TQ0073 Andropanolide Andrographolide is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. It is a natural product mainly produced from the pl...
T5814 Aurantiamide Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
TN1079 Deoxyelephantopin Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK,...
T5764 Alliin Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which s...
T5769 Stachydrine Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
T5727 CAFESTOL CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T5773 5-hydroxy-7,8-dimethoxyflavone 5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
T5754 Kavain Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of tran...
T5798 Euphorbiafactor L2 Euphorbiafactor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
T5687 WITHAFERIN A WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
T5660 Menthone Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T5558 Chelidonic acid Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
T5S2228 6'''-Feruloylspinosin 6'''-Feruloylspinosin may possess anti-inflammatory activity.
T5S1632 8-O-Acetylshanzhiside methyl ester 8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
T4S1615 Sanggenone C 1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome fu...
T6S1141 Ganoderic acid A 1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
T6S1101 Astragalin 1. Astragalin may be a potential agent in the treatment of osteoarthritis. 2. Astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inh...
TN1051 1-Caffeoylquinic acid 1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
TN1104 Cyanidin-3-O-sambubioside chloride Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
T5S1607 Morusin 1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopt...
TN1485 Chicanine Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN1806 Isotetrandrine Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1793 Isorhamnetin 3-O-galactoside Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN1786 Isomeranzin Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
TN1764 Incensole acetate Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
TN1691 Glabrol Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
TN1664 Ganoderic acid H Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting i...
TN1660 Ganoderic acid C1 Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ...
TN1637 Eurycomalactone Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits prot...
TN1620 Eriocalyxin B Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
TN1598 Dunnianol Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
TN1576 Diallyl disulfide Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
TN1562 Dehydromiltirone Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN1504 Citreorosein Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TN1493 Chrysosplenol D Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1484 Cheilanthifoline Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation ...
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
TN1466 Canthin-6-one Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflamm...
TN1448 Bornyl acetate Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials.
TN1410 Asperulosidic acid Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and ...
TN1379 Alphitolic acid Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
TN1359 Aflatoxin G1 Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN1347 8-Prenylkaempferol 8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN1341 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it ha...
TN1212 2-Hydroxyeupatolide 2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and ...
TN1182 11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
TN1143 1-O-Acetyl britannilactone 1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
TN1131 Handelin Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
TN1126 Sakuranetin Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
TN1117 Veraguensin Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity.
T6S1256 Ruscogenin 1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
TWS1977 Kamebakaurine 1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
TN1832 Kanzonol C Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T0335 Sodium salicylate Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T2878 Ginsenoside Rd Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
T3384 Wedelolactone Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T2872 Ginsenoside Re Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T3147 Pyrrolidinedithiocarbamate ammonium Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
T2992 Pinocembrin Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
T3416 Aucubin Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T3012 Mangiferin Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T2822 Ginsenoside Rb1 Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T3251 Stachydrine Hydrochloride Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.
T3662 Eleutheroside E Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus...
T2794 Astilbin Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T3862 Irigenin Irigenin has antifungal activity.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
T3427 Polydatin Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and el...
T3816 Velutin Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well a...
T0307 Tyloxapol Tyloxapol is a non-ionic liquid polymer used as a surfactant.
T3627 IQ-1S IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cart...
T2777 Ginsenoside Rg1 Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T2768 Saikosaponin A Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inflammatory, immunomodulatory, and anti...
T2140 Parthenolide (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T2759 Loganin Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent...
T3603 Sodium lauryl sulfoacetate Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T3954 Adelmidrol Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T6718 Vanillylacetone Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrh...
T6429 Caffeic Acid Phenethyl Ester Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways,...
T6204 QNZ QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T3668 Galangin Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T4S2063 Tetrahydrocoptisine 1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T3826 Polygalasaponin F Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and r...
T4S0878 Prunetin 1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
T3S0738 Yangonin 1. Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the in...
T4S1962 Beta-Asarone 1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
T6S1495 Ginsenoside Rk3 1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
T3S0737 Flavokawain A 1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-mu...
T5S1097 Neferine 1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be help...
T4518 Licochalcone D Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
T4S1050 Pristimerin 1. Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the rev...
T3S0335 Soyasaponin Bb 1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
T4126 CBL0137 CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromat...
T4361 CBL0137 hydrochloride CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperon...
T6661 SC75741 SC75741 is a potent P65 inhibitor with IC50 of 200 nM
T1301 Guaiacol Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T3729 Ethyl gallate Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependen...
T2898 Andrographolide Andrographolide(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic....
T3893 Forsythoside B Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response a...
T1930 JSH23 JSH-23, an NF-κB inhibitor(IC50= 7.1 μM), suppresses the transcriptional activity.
T0607 Dihydroartemisinin Dihydroartemisinin is a metabolite of artemisinin.
T3406 Kuromanin chloride Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
T2947 Indole-3-carbinol Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T3918 Ginsenoside Rb3 Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction ...
T3877 Esculentoside A Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. ...
T1296 Aminopar Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T2930 α-Lipoic Acid α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-L...
T3892 Isoacteoside Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
T2921 Sinomenine hydrochloride Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
T0020 Sodium 4-aminosalicylate dihydrate Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate s...
T0907 Sulfasalazine Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T2913 Schisantherin A Schisantherin A is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent....
TN1828 Kahweol Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
TN1833 Karacoline Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathwa...
TN6730 Epoxyazadiradione Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TMA1890 Icariside F2 Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects...
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
TMA1777 Hydrangenol 8-O-glucoside Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN4194 Heliangin Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4094 Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN3922 Effusanin E Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4271 Isochamaejasmine Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
TN3802 Dehydrodiconiferyl alcohol Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
TN3709 Coronarin D ethyl ether Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis....
TN3708 Coronarin D Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN3620 Celaphanol A Celaphanol A shows moderate inhibition in both NF-κB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway...
TN3614 Cearoin Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3537 Braylin Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3517 Bisacurone Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN3486 Bakkenolide IIIa Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3397 Alpinumisoflavone Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN4263 Isoangustone A Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
TN3298 8alpha-Hydroxyhirsutinolide 8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T9105 NF-κB-IN-1 NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. ...
T9033 MDK6620 MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and redu...
TN5284 Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...
TN5250 Vomifoliol Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TMA0507 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
TN5149 Tirotundin Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activ...
TN5138 Teuclatriol Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
TN5019 Siegeskaurolic acid Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN4956 Scandoside Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidati...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4938 Samidin Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN4785 Picrasidine I Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gen...
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN4315 Isonardosinone Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4652 Niazimicin Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
TN4648 Nepetoidin B Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
TN4633 Neocryptotanshinone II Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4604 Myricanone Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4490 Manassantin B Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4437 Licorisoflavan A Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
TN4399 Kushenol C Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
TN4394 Kobophenol A Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
TN4374 Kaerophyllin Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
TN3219 7,8-Didehydrocimigenol 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
TN1834 Kobusin Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
TN2165 Rubrofusarin-6-O-beta-D-gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it...
T15198 Edasalonexent Edasalonexent is an orally bioavailable inhibitor of NF-κB.
T10383 Asatone Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JN...
T10318 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloi...
T14491 B022 B022 is an inhibitor of NF-κB-inducing kinase (NIK) (Ki: 4.2 nM). B022 protects liver from oxidative stress, toxin-induced inflammation, and injury.
T11060 DMAPT DMAPT (Dimethylamino Parthenol) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor. For cell populations in AML cells, th...
T11018 DHMEQ racemate DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
T10981 DCZ0415 DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can imp...
TN2327 Zedoarondiol Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
TN2309 Withanolide A Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
TN2232 Soyasaponin Ab Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
TN2179 Saponarin Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
TN2178 Sanggenone H Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
TN2177 Sanggenol L Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
TN2164 Rubipodanone A Rubipodanone A is a natural product
T12942 SN50 SN50 is a cell permeable NF-κB translocation inhibitor.
TN2163 Rubioncolin C Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM.
TN2095 Pomiferin Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TN2089 Platycodin D3 Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway ...
TN2080 Pinoresinol Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric...
TN2079 (-)-Pinoresinol Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulati...
TN2075 Pimaric acid Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
TN2062 Phyllanthin Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
TN2008 Okanin Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
TN1960 Mussaenoside Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN1953 Morusinol Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
TN1933 Mitraphylline Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
TN1923 Mesaconine Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation an...
TN1866 Licoricesaponin G2 Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
TN1846 Kushenol W Kushenol W is a natural product
T12828 Salicortin Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity...
T12975 Sootepin D Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
TN3209 7,3',4'-Trihydroxyflavone 3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
T3S1707 Dendrophenol Dendrophenol is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
TN3070 4beta-Hydroxywithanolide E 4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
TN3049 4-Methoxycinnamyl alcohol 4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN2588 11-Hydroxytephrosin 11-Hydroxytephrosin inhibits NF-kappaB activity.
TN2546 1-Isomangostin 1-Isomangostin has cytotoxic, and anticomplement activities.
TN2539 1beta-Hydroxyalantolactone 1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
TN2451 Isosalvianolic acid B Isosalvianolic acid B is a natural from Salviae miltiorrhizae
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
T5S0993 Kurarinone Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T4366 Quinovic acid Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
T4237 Rubiadin 1-methyl ether Rubiadin 1-methyl ether is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of ...
T3S1692 Octahydrocurcumin Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
T13686 Ergolide Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB. Ergolide is a se...
T3S0209 Vincristine Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
T2S1040 Jolkinolide B Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
T17309 (R)-(-)-Ibuprofen (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.
T17252 WAY-204688 WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT...
T17217 Vamorolone Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
T17157 TRAF-STOP inhibitor 6877002 TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activat...
T16974 TAK-243 TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
T16706 Quinoclamine Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
T16324 Nimbolide Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
T16290 NIK SMI1 NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
T13625 Coronalolic acid Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
T15601 IT-901 IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT...
T13604 CDDO-dhTFEA CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restor...
T13265 Urolithin B Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
SN50 acetate (213546-53-3 free base)
T12942LCAS T12942L
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
sodium lauroyl-α-hydroxyethyl sulfonate
T7283CAS T7283
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
Irisolidone
TN1035CAS 2345-17-7
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
Kukoamine A
TN1016CAS 75288-96-9
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
Epimagnolin B
TN1009CAS 1134188-26-3
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
C25-140
T7889CAS 1358099-18-9
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
Myrislignan
T4S1540CAS 171485-39-5
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
Isoliquiritin apioside
T3860CAS 120926-46-7
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
Hesperidin methylchalcone
T7980CAS 24292-52-2
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
Cyclo(his-pro)
T7511CAS 53109-32-3
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathw...
CID-2858522
TQ0305CAS 758679-97-9
CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
14-Deoxy-11,12-didehydroandrographolide
TQ0185CAS 42895-58-9
14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
Inulicin
TQ0169CAS 33627-41-7
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
Rocaglamide
TQ0131CAS 84573-16-0
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...
Andropanolide
TQ0073CAS 869807-57-8
Andrographolide is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. It is a natural product mainly produced from the pl...
Aurantiamide
T5814CAS 58115-31-4
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Auran...
Deoxyelephantopin
TN1079CAS 29307-03-7
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK,...
Alliin
T5764CAS 556-27-4
Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which s...
Stachydrine
T5769CAS 471-87-4
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibi...
CAFESTOL
T5727CAS 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
5-hydroxy-7,8-dimethoxyflavone
T5773CAS 3570-62-5
5-hydroxy-7,8-dimethoxyflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone signific...
Kavain
T5754CAS 3155-48-4
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of tran...
euphorbiafactor L2
T5798CAS 218916-51-9
Euphorbiafactor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
WITHAFERIN A
T5687CAS 5119-48-2
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
Menthone
T5660CAS 10458-14-7
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
Chelidonic acid
T5558CAS 99-32-1
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also sh...
6'''-Feruloylspinosin
T5S2228CAS 77690-92-7
6'''-Feruloylspinosin may possess anti-inflammatory activity.
8-O-Acetylshanzhiside methyl ester
T5S1632CAS 57420-46-9
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
Sanggenone C
T4S1615CAS 80651-76-9
1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome fu...
Ganoderic acid A
T6S1141CAS 81907-62-2
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
Astragalin
T6S1101CAS 480-10-4
1. Astragalin may be a potential agent in the treatment of osteoarthritis. 2. Astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inh...
1-Caffeoylquinic acid
TN1051CAS 1241-87-8
1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
Cyanidin-3-O-sambubioside chloride
TN1104CAS 33012-73-6
Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
Morusin
T5S1607CAS 62596-29-6
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopt...
Chicanine
TN1485CAS 78919-28-5
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Isotetrandrine
TN1806CAS 477-57-6
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
Isorhamnetin 3-O-galactoside
TN1793CAS 6743-92-6
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
Isomeranzin
TN1786CAS 1088-17-1
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
Incensole acetate
TN1764CAS 34701-53-6
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
Glabrol
TN1691CAS 59870-65-4
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
Ganoderic acid H
TN1664CAS 98665-19-1
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting i...
Ganoderic acid C1
TN1660CAS 95311-97-0
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ...
Eurycomalactone
TN1637CAS 23062-24-0
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits prot...
Eriocalyxin B
TN1620CAS 84745-95-9
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
Dunnianol
TN1598CAS 139726-29-7
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
Diallyl disulfide
TN1576CAS 2179-57-9
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
Dehydromiltirone
TN1562CAS 116064-77-8
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
Citreorosein
TN1504CAS 481-73-2
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
Chrysosplenol D
TN1493CAS 14965-20-9
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
Cheilanthifoline
TN1484CAS 483-44-3
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation ...
Schisandrone
TN1116CAS 98619-25-1
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
Canthin-6-one
TN1466CAS 479-43-6
Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflamm...
Bornyl acetate
TN1448CAS 5655-61-8
Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials.
Asperulosidic acid
TN1410CAS 25368-11-0
Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and ...
Alphitolic acid
TN1379CAS 19533-92-7
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
Aflatoxin G1
TN1359CAS 1165-39-5
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
8-Prenylkaempferol
TN1347CAS 28610-31-3
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
8-Deoxygartanin
TN1341CAS 33390-41-9
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it ha...
2-Hydroxyeupatolide
TN1212CAS 72229-33-5
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and ...
11-Keto-beta-boswellic acid
TN1182CAS 17019-92-0
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
1-O-Acetyl britannilactone
TN1143CAS 681457-46-5
1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
Isodeoxyelephantopin
TN1141CAS 38927-54-7
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
Handelin
TN1131CAS 62687-22-3
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
Sakuranetin
TN1126CAS 2957-21-3
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
Veraguensin
TN1117CAS 19950-55-1
Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity.
Ruscogenin
T6S1256CAS 472-11-7
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
Kamebakaurine
TWS1977CAS 73981-34-7
1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stre...
Kanzonol C
TN1832CAS 151135-82-9
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
Glucosamine
T0429CAS 3416-24-8
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Sodium salicylate
T0335CAS 54-21-7
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
Magnolol
T3000CAS 528-43-8
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
Ginsenoside Rd
T2878CAS 52705-93-8
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
Wedelolactone
T3384CAS 524-12-9
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
Ginsenoside Re
T2872CAS 52286-59-6
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
Pyrrolidinedithiocarbamate ammonium
T3147CAS 5108-96-3
Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
Pinocembrin
T2992CAS 480-39-7
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
Aucubin
T3416CAS 479-98-1
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Bengenin
T0122CAS 477-90-7
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Mangiferin
T3012CAS 4773-96-0
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
Vinpocetine
T0167CAS 42971-09-5
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Ginsenoside Rb1
T2822CAS 41753-43-9
Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
Stachydrine Hydrochloride
T3251CAS 4136-37-2
Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.
Eleutheroside E
T3662CAS 39432-56-9
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus...
Astilbin
T2794CAS 29838-67-3
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
Irigenin
T3862CAS 548-76-5
Irigenin has antifungal activity.
Isosteviol
T3332CAS 27975-19-5
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...
Polydatin
T3427CAS 27208-80-6
Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and el...
Velutin
T3816CAS 25739-41-7
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well a...
Tyloxapol
T0307CAS 25301-02-4
Tyloxapol is a non-ionic liquid polymer used as a surfactant.
IQ-1S
T3627CAS 23146-22-7
IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cart...
Ginsenoside Rg1
T2777CAS 22427-39-0
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
Saikosaponin D
T3913CAS 20874-52-6
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
Saikosaponin A
T2768CAS 20736-09-8
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inflammatory, immunomodulatory, and anti...
Parthenolide
T2140CAS 20554-84-1
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Loganin
T2759CAS 18524-94-2
Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent...
Sodium lauryl sulfoacetate
T3603CAS 1847-58-1
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
Adelmidrol
T3954CAS 1675-66-7
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
Vanillylacetone
T6718CAS 122-48-5
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrh...
Caffeic Acid Phenethyl Ester
T6429CAS 104594-70-9
Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways,...
QNZ
T6204CAS 545380-34-5
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
Galangin
T3668CAS 548-83-4
Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
Tetrahydrocoptisine
T4S2063CAS 7461-02-1
1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
Polygalasaponin F
T3826CAS 882664-74-6
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and r...
Prunetin
T4S0878CAS 552-59-0
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
yangonin
T3S0738CAS 500-62-9
1. Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. 2. Yangonin could be a valuable candidate for the in...
beta-Asarone
T4S1962CAS 5273-86-9
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
Ginsenoside Rk3
T6S1495CAS 364779-15-7
1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
Flavokawain A
T3S0737CAS 3420-72-2
1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-mu...
Neferine
T5S1097CAS 2292-16-2
1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be help...
Licochalcone D
T4518CAS 144506-15-0
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
Pristimerin
T4S1050CAS 1258-84-0
1. Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the rev...
Soyasaponin Bb
T3S0335CAS 51330-27-9
1. Soyasaponin Bb can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kapp...
CBL0137
T4126CAS 1197996-80-7
CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromat...
CBL0137 hydrochloride
T4361CAS 1197397-89-9
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperon...
SC75741
T6661CAS 913822-46-5
SC75741 is a potent P65 inhibitor with IC50 of 200 nM
Guaiacol
T1301CAS 90-05-1
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
Mesalamine
T0646CAS 89-57-6
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
Ethyl gallate
T3729CAS 831-61-8
Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependen...
Andrographolide
T2898CAS 5508-58-7
Andrographolide(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic....
Forsythoside B
T3893CAS 81525-13-5
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response a...
JSH23
T1930CAS 749886-87-1
JSH-23, an NF-κB inhibitor(IC50= 7.1 μM), suppresses the transcriptional activity.
Dihydroartemisinin
T0607CAS 71939-50-9
Dihydroartemisinin is a metabolite of artemisinin.
Kuromanin chloride
T3406CAS 7084-24-4
Cyanidin-3-O-glucoside chloride is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.
Indole-3-carbinol
T2947CAS 700-06-1
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
Ginsenoside Rb3
T3918CAS 68406-26-8
Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction ...
Esculentoside A
T3877CAS 65497-07-6
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. ...
Aminopar
T1296CAS 65-49-6
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
α-Lipoic Acid
T2930CAS 62-46-4
α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-L...
Isoacteoside
T3892CAS 61303-13-7
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
Sinomenine hydrochloride
T2921CAS 6080-33-7
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
Sodium 4-aminosalicylate dihydrate
T0020CAS 6018-19-5
Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate s...
Sulfasalazine
T0907CAS 599-79-1
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
Schisantherin A
T2913CAS 58546-56-8
Schisantherin A is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent....
Kahweol
TN1828CAS 6894-43-5
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
Karacoline
TN1833CAS 39089-30-0
Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathwa...
Epoxyazadiradione
TN6730CAS 18385-59-6
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Icariside F2
TMA1890CAS 115009-57-9
Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects...
Hydrangenol
TN4234CAS 480-47-7
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
Hydrangenol 8-O-glucoside
TMA1777CAS 67600-94-6
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
Heliangin
TN4194CAS 13323-48-3
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cel...
Grossamide
TN4171CAS 80510-06-1
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
Goshonoside F5
TN4162CAS 90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Gallocatechin gallate
TN4094CAS 5127-64-0
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931CAS 57719-81-0
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Effusanin E
TN3922CAS 76470-15-0
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Isochamaejasmine
TN4271CAS 93859-63-3
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
Dehydrodiconiferyl alcohol
TN3802CAS 4263-87-0
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
Coronarin D ethyl ether
TN3709CAS 138965-89-6
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis....
Coronarin D
TN3708CAS 119188-37-3
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
Chlojaponilactone B
TN3635CAS 1449382-91-5
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Celaphanol A
TN3620CAS 244204-40-8
Celaphanol A shows moderate inhibition in both NF-κB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway...
Cearoin
TN3614CAS 52811-37-7
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Broussonin A
TN3539CAS 73731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Braylin
TN3537CAS 6054-10-0
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
Bisacurone
TN3517CAS 120681-81-4
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Bakkenolide IIIa
TN3486CAS 915289-60-0
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Alpinumisoflavone
TN3397CAS 34086-50-5
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
Isoangustone A
TN4263CAS 129280-34-8
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Isodunnianol
TN4286CAS 139726-30-0
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
8alpha-Hydroxyhirsutinolide
TN3298CAS 1394156-45-6
8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
NF-κB-IN-1
T9105CAS 1227098-15-8
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. ...
MDK6620
T9033CAS 304456-62-0
MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and redu...
Sodium Houttuyfonate
TN5284CAS 83766-73-8
Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...
Vomifoliol
TN5250CAS 23526-45-6
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Tomatidine
TMA0507CAS 77-59-8
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tirotundin
TN5149CAS 56377-67-4
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activ...
Teuclatriol
TN5138CAS 152110-17-3
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
Siegeskaurolic acid
TN5019CAS 52645-97-3
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Scandoside
TN4956CAS 18842-99-4
Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidati...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
Samidin
TN4938CAS 477-33-8
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Picrasidine I
TN4785CAS 100234-59-1
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gen...
Nyasol
TN4683CAS 96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
Isonardosinone
TN4315CAS 27062-01-7
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Niazimicin
TN4652CAS 147821-49-6
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
Nepetoidin B
TN4648CAS 55486-06-1
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
Neocryptotanshinone II
TN4633CAS 27468-20-8
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
Myricanone
TN4604CAS 32492-74-3
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Manassantin B
TN4490CAS 88497-88-5
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Licorisoflavan A
TN4437CAS 129314-37-0
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
Kushenol C
TN4399CAS 99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
Kobophenol A
TN4394CAS 124027-58-3
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
Kazinol U
TN4383CAS 1238116-48-7
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
Kaerophyllin
TN4374CAS 75590-33-9
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
Agrimonolide
TN3364CAS 21499-24-1
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
7,8-Didehydrocimigenol
TN3219CAS 150972-72-8
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
Kobusin
TN1834CAS 36150-23-9
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
Rubrofusarin-6-O-beta-D-gentiobioside
TN2165CAS 24577-90-0
Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it...
Edasalonexent
T15198CAS 1204317-86-1
Edasalonexent is an orally bioavailable inhibitor of NF-κB.
Asatone
T10383CAS 38451-63-7
Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JN...
Anatabine dicitrate
T10318CAS T10318
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloi...
B022
T14491CAS 1202764-53-1
B022 is an inhibitor of NF-κB-inducing kinase (NIK) (Ki: 4.2 nM). B022 protects liver from oxidative stress, toxin-induced inflammation, and injury.
DMAPT
T11060CAS 870677-05-7
DMAPT (Dimethylamino Parthenol) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor. For cell populations in AML cells, th...
DHMEQ racemate
T11018CAS 287194-38-1
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
DCZ0415
T10981CAS 2242470-43-3
DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can imp...
Zedoarondiol
TN2327CAS 98644-24-7
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
Withanolide A
TN2309CAS 32911-62-9
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
Soyasaponin Ab
TN2232CAS 118194-13-1
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
Sophoflavescenol
TN2217CAS 216450-65-6
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Saponarin
TN2179CAS 20310-89-8
Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
Sanggenone H
TN2178CAS 86450-80-8
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimula...
Sanggenol L
TN2177CAS 329319-20-2
Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
Rubipodanone A
TN2164CAS 2170211-22-8
Rubipodanone A is a natural product
SN50
T12942CAS 213546-53-3
SN50 is a cell permeable NF-κB translocation inhibitor.
Rubioncolin C
TN2163CAS 132242-52-5
Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM.
Pomiferin
TN2095CAS 572-03-2
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
Platycodin D3
TN2089CAS 67884-03-1
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway ...
Pinoresinol
TN2080CAS 487-36-5
Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric...
(-)-Pinoresinol
TN2079CAS 81446-29-9
Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulati...
Pimaric acid
TN2075CAS 127-27-5
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
Phyllanthin
TN2062CAS 10351-88-9
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
Okanin
TN2008CAS 484-76-4
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
Mussaenoside
TN1960CAS 64421-27-8
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
Morusinol
TN1953CAS 62949-93-3
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or strok...
Mitraphylline
TN1933CAS 509-80-8
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
Mesaconine
TN1923CAS 6792-09-2
Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation an...
Licoricesaponin G2
TN1866CAS 118441-84-2
Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
Kushenol W
TN1846CAS 254886-76-5
Kushenol W is a natural product
Salicortin
T12828CAS 1887055-63-1
Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity...
Sootepin D
T12975CAS 1154518-97-4
Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
7,3',4'-Trihydroxyflavone
TN3209CAS 2150-11-0
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
Dendrophenol
T3S1707CAS 108853-14-1
Dendrophenol is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119CAS 113981-49-0
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and ...
4beta-Hydroxywithanolide E
TN3070CAS 54334-04-2
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
4-Methoxycinnamyl alcohol
TN3049CAS 53484-50-7
4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
11-Hydroxytephrosin
TN2588CAS 72458-85-6
11-Hydroxytephrosin inhibits NF-kappaB activity.
1-Isomangostin
TN2546CAS 19275-44-6
1-Isomangostin has cytotoxic, and anticomplement activities.
1beta-Hydroxyalantolactone
TN2539CAS 68776-47-6
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
Isosalvianolic acid B
TN2451CAS 930573-88-9
Isosalvianolic acid B is a natural from Salviae miltiorrhizae
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Kurarinone
T5S0993CAS 34981-26-5
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
Quinovic acid
T4366CAS 465-74-7
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
Rubiadin 1-methyl ether
T4237CAS 7460-43-7
Rubiadin 1-methyl ether is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of ...
Octahydrocurcumin
T3S1692CAS 36062-07-4
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
Ergolide
T13686CAS 54999-07-4
Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB. Ergolide is a se...
Vincristine
T3S0209CAS 57-22-7
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
(R)-(-)-Ibuprofen
T17309CAS 51146-57-7
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.
WAY-204688
T17252CAS 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT...
Vamorolone
T17217CAS 13209-41-1
Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
TRAF-STOP inhibitor 6877002
T17157CAS 433249-94-6
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activat...
TAK-243
T16974CAS 1450833-55-2
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
Quinoclamine
T16706CAS 2797-51-5
Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
Nimbolide
T16324CAS 25990-37-8
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
NIK SMI1
T16290CAS 1660114-31-7
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
Coronalolic acid
T13625CAS 268214-52-4
Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
IT-901
T15601CAS 1584121-99-2
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT...
CDDO-dhTFEA
T13604CAS 1191265-33-4
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restor...
Urolithin B
T13265CAS 1139-83-9
Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
Pranlukast
T0694CAS 103177-37-3
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...