AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	Product name	CAS No.	Purity
T6129	GSK-1070916	942918-07-2	98.51%
T6129	GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the ...
T3863	Chikusetsusaponin IVa	51415-02-2	98.46%
T3863	Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may b...
T6854	GSK621	1346607-05-3	98.44%
T6854	GSK621 is a specific and potent AMPK activator.
T6S1784	Brazilin	474-07-7	98.31%
T6S1784	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell ...
TN2346	Mogrol	88930-15-8	98.21%
TN2346	Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	98.16%
TN1440	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor ...
T4427	PF-06409577	1467057-23-3	98.16%
T4427	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
T15137	DK419	2102672-22-8	98.15%
T15137	DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
T13368	YLF-466D	1273323-67-3	98.04%
T13368	YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.
T2133	Adenosine monophosphate	61-19-8	98.04%
T2133	Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeosta...
T16156	MT 63-78	1179347-65-9	98.03%
T16156	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathway...
T1477	AICAR	2627-69-2	98.00%
T1477	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
T7535	RGX-202	353-09-3	98%
T7535	RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates...
T7327	7-Methoxyisoflavone	1621-56-3	98%
T7327	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
T20029	Buformin hydrochloride	1190-53-0	97.83%
T20029	Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from t...
T9010	IMM-H007	1221412-23-2	97.73%
T9010	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
T0853L	Adenosine 5'-monophosphate monohydrate	18422-05-4	97.68%
T0853L	Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric ...
TN1702	Glycycoumarin	94805-82-0	97.64%
TN1702	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
T60128	N,N-Didesethyl Sunitinib Hydrochloride	873077-70-4	97.1%
T60128	N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.
T24626	PF-249	1467059-70-6	97.02%
T24626	PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.