y-16

Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM.

(Rac)-WAY-161503 is a selective and high-affinity agonist of the 5-HT2C receptor [Ki: 4 nM; EC50: 12 nM], exhibiting anti-obesity and antidepressant effects.

15-Hydroxy-16-kauren-19-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131456.

WAY-166818 (WAY-818) is a synthetic nonsteroidal estrogen that acts as a selective agonist for ERβ.

The compound is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase.

MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.

AY-16804 is an inhibitor of platelet aggregation.

11-Deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of Prostaglandin E2 (PGE2), acting as an agonist for both EP2 and EP3 receptors. It effectively inhibits gastric acid secretion and ulcer formation in rats, with ED50 values of 1 mg/kg and 0.021 mg/kg, respectively. This compound is also 900 times more potent than Prostaglandin F2α (PGF2α) in inducing contraction of human respiratory tract smooth muscle in vitro.

WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER), inhibiting NF-kB transcriptional activity while being devoid of conventional estrogenic activity.

11,15-Dihydroxy-16-kauren-19-oic acid is a natural product

15,16-Dihydro-15-methoxy-16-oxohardwickiic acid is a natural product for research related to life sciences. The catalog number is TN2629 and the CAS number is 115783-35-2.

10-Hydroxy-16-epiaffinine, a natural product of Rauvolfia (Apocynaceae), has the catalog number TN6039 and the CAS number 82513-70-0. It can be used as a reference standard.

15-Methoxy-16-oxo-15,16H-strictic acid is a natural product of Pulicaria, Asteraceae. The catalog number is TN6526 and the CAS number is 1356388-38-9. 15-Methoxy-16-oxo-15,16H-strictic acid can be used as a reference standard.

Y16 acetate(429653-73-6 free base) is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.

(Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol is a useful organic compound for research related to life sciences and the catalog number is T125942.

WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).

WAY 163909 hydrochloride is an effective agonist for the serotonin 5-HT2C receptor, with an EC50 value of 8 nM and a maximal efficacy of 90%. It shows minimal activity at the 5-HT2A receptor. The compound displays its selectivity with a Ki value of 10.5 nM at the 5-HT2C receptor, compared to higher Ki values at 5-HT2A (212 nM), 5-HT7 (343 nM), and 5-HT2B (485 nM) receptors, and it lacks significant activity at various other receptors.

Y16526 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 of 0.03 μM. Y16524 shows potential for research in acute myeloid leukemia (AML).

Y16524 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 value of 0.01 μM. It shows potential for research in acute myeloid leukemia (AML).

WAY 161503 hydrochloride is a 5-HT2C receptor agonist.

EM 5519 is an antitumor antibiotic.

Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity for the treatment of metastatic melanoma that cannot be resected or has a BRAF V600E or V600K mutation.

LY 163443 is an dual receptor antagonist of LTD4 and LTE4.

LY 164929 is a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.