valsartan

Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.

Sacubitril Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM.

Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.

Valsartan Ethyl Ester is an impurity of Valsartan, an angiotensin II receptor antagonist used for the treatment of high blood pressure and heart failure.

Valsartan benzyl ester is a intermediate of Valsartan.

4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.

Desvaleryl valsartan is a potential impurity found in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist valsartan. It is a degradation product formed under acidic conditions.

Valsartan acid, a byproduct of the angiotensin II type 1 (AT1) receptor antagonist Valsartan, emerges through the activated sludge treatment process and has been identified as a contaminant in drinking water.

rac-Valsartan-d9 is a deuterated compound of rac-Valsartan. rac-Valsartan has a CAS number of 137862-53-4. Valsartan is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.

Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.

2R,4R-Sacubitril is an impurity of Sacubitril, which is used in combination with valsartan for the treatment of patients with heart failure.

2S,4R-Sacubitril is an impurity of Sacubitril, which is used in combination with valsartan [for the treatment of patients with heart failure].

(Z)2S,4R-Sacubitril is an impurity of Sacubitril, a compound used in combination with valsartan for treating patients with heart failure.

Losartan potassium impurity E is a compound of Valsartan impurity.

Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders.