uridine

Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.

Uridine triphosphate trisodium salt (UTP, Trisodium Salt) is a nucleotide.

Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.

Cytidine (Cytosine-1-β-D-ribofuranoside) is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and uridine are utilized in RNA synthesis.

Cytidine 5'-diphosphate trisodium salt (CDP) catalyzes the production of Cytidine triphosphate (CTP) for DNA and RNA synthesis by transferring a phosphoryl group from ATP to cytidine monophosphate (CMP) through the action of uridine monophosphate kinase (UMPK).

Uridine (Uridin) is a nucleoside compound, one of the four bases that make up RNA, that replaces thymine in DNA during transcription and pairs with adenine.

3'-Azido-3'-deoxy-beta-L-uridine is a nucleoside derivative.

Uridine triphosphate (UTP) is a purine nucleotide P2U receptor agonist with potential use in lung cancer treatment. By activating P2Y2 receptors, it enhances the proliferation of human cancerous ductal epithelial cells. Additionally, UTP induces fibrotic responses in cardiac fibroblasts through P2Y2 receptor activation and prolongs the action potential duration of guinea pig papillary muscles via the P2Y2 purinergic receptor.

Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium)) acts as an agonist for the purinergic P2Y6 receptor. This compound selectively induces the accumulation of inositol phosphate in 1321N1 cells expressing P2Y6 receptors, with an EC50 value of 28 nM. Additionally, it stimulates DNA synthesis in rat aortic smooth muscle cells.

Uridine-5'-O-(3-thiotriphosphate) tetrasodium (UTPγS) is a stable analog of Uridine triphosphate (UTP) and acts as a potent agonist for P2Y2 and P2Y4 receptors, offering enhanced metabolic stability. It can stimulate the generation of inositol phosphates in 1321N1 astrocytoma cells, which stably express phospholipase C-coupled human P2U purinergic receptors (EC50= 240 nM).

Uridine-5'-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5'-monophosphate (5'-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002)

5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.

Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a precursor of many plant cell wall polysaccharides and is required for the production of seed mucilage.Uridine diphosphate glucuronic acid ammonium is a precursor of pathogenic fungi. ammonium is a key metabolite for pod polysaccharide synthesis in the pathogenic fungus Cryptococcus neoformans.

Uridine 5'-triphosphate tris salt is an endogenous metabolite.

2'-Deoxy-2'-fluoro-N3-[(pyrid-2-yl)methyl]uridine, a uridine analogue, demonstrates potential antiepileptic properties and its analogues are studied for anticonvulsant and anxiolytic effects, as well as for creating new antihypertensive agents [1].

Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester, a purine nucleoside analogue, demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms including inhibition of DNA synthesis and induction of apoptosis [1].

Uridine-5-(N-Fmoc-methylamino)-acetyl (9-fluorenylmethyl) ester, a purine nucleoside analogue, exhibits broad antitumor activity, specifically targeting indolent lymphoid malignancies through mechanisms including the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis, among others [1].

2'-O-Acetyl-5'-O-benzoyl-3'-O-(2-methoxyethyl) uridine, an analog of uridine, is known for its potential antiepileptic properties and is used in research on anticonvulsant and anxiolytic activities, as well as in the development of novel antihypertensive agents [1].

2'-Deoxy-2'-fluoro-N3-[(pyrid-4-yl)methyl]uridine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and induction of apoptosis, among other mechanisms [1].

2'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis, among other mechanisms [1].

N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, exhibits potential antiepileptic properties. Its analogs are employed in research on anticonvulsant and anxiolytic effects, and aid in the development of novel antihypertensive agents [1].

Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].

Aminoallyl-UTP (5-(3-Aminoallyl)uridine-5'-O-triphosphate) is an amine-modified nucleotide utilized in affinity-tagged UTP synthesis. Its incorporation into complementary RNA (cRNA) and bacterial transfer-messenger RNA (tmRNA) enables the creation of fluorescently labeled probes for microarrays.