type

Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7 0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.

Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor activity.

Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.

Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride), a widely used anti-diabetic drug, exhibits potential anti-Y properties by inhibiting the proliferation of various Y cells, including colon and prostate.

3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, 3-hydroxybutyrate is synthesized in the liver from acetyl-CoA and can be used as an energy source by the brain when blood glucose is low. Blood levels of 3-hydroxybutyric acid levels may be monitored in diabetic patients to look for diabetic ketoacidosis. Persistent mild hyperketonemia is a common finding in newborns. Ketone bodies serve as an indispensable source of energy for extrahepatic tissues, especially the brain and lung of developing mammals. Another important function of ketone bodies is to provide acetoacetyl-CoA and acetyl-CoA for the synthesis of cholesterol, fatty acids, and complex lipids. During the early postnatal period, acetoacetate (AcAc) and beta-hydroxybutyrate are preferred over glucose as substrates for synthesis of phospholipids and sphingolipids in accord with requirements for brain growth and myelination. Thus, during the first 2 weeks of postnatal development, when the accumulation of cholesterol and phospholipids accelerates, the proportion of ketone bodies incorporated into these lipids increases. On the other hand, an increased proportion of ketone bodies is utilized for cerebroside synthesis during the period of active myelination. In the lung, AcAc serves better than glucose as a precursor for the synthesis of lung phospholipids. The synthesized lipids, particularly dipalmitoylphosphatidylcholine, are incorporated into surfactant, and thus have a potential role in supplying adequate surfactant lipids to maintain lung function during the early days of life (PMID: 3884391 ). 3-Hydroxybutyric acid is found to be associated with fumarase deficiency and medium-chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a highly potent and selective MEK inhibitor that specifically inhibits MEK1 2 (IC50: 2 nM).

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Collagen, Type I, from bovine achilles tendon is a type I collagen derived from bovine achilles tendon, which is widely found in marine invertebrate tissues. Collagen, Type I, from bovine achilles tendon is the only component of collagen fibers that make up the dermis, and plays a major role in bone and connective tissue. connective tissues, and functions primarily by forming and maintaining the integrity of the skeleton.

Type III-Intermediate 8 is a useful organic compound for research related to life sciences and the catalog number is T9562.

Type III-Intermediate7 is a useful organic compound for research related to life sciences and the catalog number is T9563.

C-Type Natriuretic Peptide (CNP) (1-22), human, is the 1-22 fragment of the parent C-Type Natriuretic Peptide.

C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), human acetate inhibits cAMP synthesis stimulated by histamine and 5-HT or directly by Forskolin.

N-type calcium channel blocker-1 is an orally active analgesic agent with a high affinity for functionally blocking N-type calcium channels.

TA 0910 acid-type is a metabolite of TA 0910, a metabolically stable analog of thyrotropin-releasing hormone (TA-0910).

Collagenase Type II, an endopeptidic matrix metalloproteinase MMP-8 derived from the bacterium Clostridium histolyticum, preferentially degrades type I collagen and is commonly used in tissues requiring high digestive efficiency such as pancreas and liver.

Collagenase Type IV is an endopeptidic matrix metalloproteinase MMP-18 derived from the bacterium Clostridium histolyticum that primarily degrades collagen type IV and VII and is commonly used to break down basement membranes (e.g., neural tissue, renal tissue) because of its mild activity.

Collagenase Type III, an endopeptide matrix metalloproteinase MMP-13 derived from the bacterium Clostridium histolyticum, preferentially degrades type III collagen and is commonly used in sensitive tissues such as breast, tumor, and uterus due to its mild activity.

Collagenase Type V, an endopeptidic matrix metalloproteinase MMP from the bacterium Clostridium histolyticum, can be used for islet tissue isolation.

Collagenase, Type VI (EC 3.4.24.3) is an enzyme specialized in degrading Type VI collagen, a component found in various tissues including skin, heart, blood vessels, cartilage, and the cell membranes in synovia. Excessive activity of this enzyme can lead to extracellular matrix disorders. Additionally, Collagenase, Type VI serves as a biomarker for tumor invasion and metastasis. It acts specifically on peptide bonds between proline and glycine. Exploiting this specificity, modified electrodes can be used to rapidly and sensitively detect its concentration levels in experiments.

Collagenase, Type VII (EC 3.4.24.3), is an enzyme capable of inducing thalamic hemorrhage.

Collagenase, Type VIII, has the capability to hydrolyze Type VIII collagen, and may be utilized in the study of atherosclerosis development. Type VIII collagen serves as a regulator of endothelial cell differentiation and angiogenesis, acts as a substrate for the adhesion and migration of cells such as smooth muscle cells, and may accumulate in atherosclerosis. Following the activation by endotoxins, the expression of Collagenase, Type VIII can reduce the production of Type VIII collagen, potentially inhibiting the progression of atherosclerosis.

Collagenase (Type B, animal free) is devoid of animal-derived components and exhibits enhanced collagenase and caseinase activities.