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By Target- Potassium Channel
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Results for "
twik-related
" in TargetMol Product Catalog- Inhibitors & Agonists5
- Recombinant Protein1
RU-TRAAK-2
T600611210538-56-9
RU-TRAAK-2 is a reversible inhibitor of TWIK-related arachidonic acid-stimulated K+ channel with no activity for non-K2P channels including Kv1.2, GIRK2, and Slo1.
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A2764 dihydrochloride
T7775861038-72-4
A2764 dihydrochloride is a highly selective inhibitor of TWIK-related spinal cord K+ channel (TRESK).
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TWIK-1/TREK-1-IN-1
T788681440532-30-8
Compound 2a, identified as TWIK-1 TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1 TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1 TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 μM for TREK-1 homodimers and 14.6 μM for TWIK-1 TREK-1 heterodimers, demonstrating antidepressant-like effects [1].
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