trehalose

Trehalose 6-phosphate potassium salt hydrate (α,α-Trehalose 6-phosphate potassium salt hydrate) is a Trehalose derivative, an intermediate in trehalose biosynthesis, and an important signaling metabolite in plants. It can regulate root branching through the master kinase SNF1-related kinase-1 (SnRK1) and rapamycin target (TOR).

D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

D-(+)-Trehalose dihydrate (α,α-Trehalose dihydrate) is a natural α-linked disaccharide formed by an α, α-1, 1-glucoside bond between two α-glucose units.

Trehalose 6-behenate is a vaccine adjuvant that skews the immune response towards Th1/Th17.

α,α-Trehalose 6-phosphate potassium is a glucose analogue with potent anti-hyperglycemic activity. It serves as a central signaling molecule in carbon metabolism regulation, particularly in plants and microorganisms, where it functions as a sensor for sucrose or glucose levels. In vivo, Tre6P is rapidly converted to its end product, α,α'-trehalose, by the enzyme α,α-Trehalose 6-phosphate phosphatase (T6PP). Beyond its role as a metabolic intermediate, Tre6P demonstrates potential in diabetic models to alleviate hyperglycemic symptoms by modulating glucose homeostasis.

Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].

D-(+)-Trehalose (Standard) is the standard substance of D-(+)-Trehalose, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

Trehalose C12 (α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate) is a non-reducing disaccharide utilized for its amphiphilic properties as an emulsifier, surfactant, encapsulating material, and in biochemical research on cellular processes and membrane interactions.

Trehalose C14 is a surfactant.

β,β-Trehalose, a trehalose analog, supports the growth of Cuscuta shoot tips and can be cleaved by nonspecific β-glucosidase [1].

6-O-Bis-(4,5-dimethoxy-2-nitrobenzyloxyphosphoryl)-D-trehalose is a synthetic compound that disrupts sugar signaling pathways in plants. Upon absorption by plants and exposure to light, it triggers the release of T6P, activating internal signaling pathways. This compound is utilized in research on plant biosynthesis.

D-(+)-Trehalose-13C12 is an isotopic label of D- (+)-Trehalose, enriched with 13C. This compound is pervasively found and often employed as a food ingredient and a shape-forming agent for active molecules.

6,6′-Trehalose dioleate (6,6′-TDO) is a glycolipid extensively used for in vivo and in vitro mRNA delivery. This compound effectively encapsulates mRNA encoding hemagglutinin A (HA) from influenza A virus for use within lipid nanoparticles (LNPs), enhancing the secretion of Ifn-γ, Il-2, and Tnf-α from isolated murine spleen cells. When administered via intramuscular injection in mice, LNPs containing 6,6′-TDO predominantly accumulate in the liver and spleen. Unlike LNP formulations without 6,6′-TDO, those containing 6,6′-TDO do not reduce serum levels of blood urea nitrogen (BUN) or elevate levels of lactate dehydrogenase (LDH), troponin I, alanine aminotransferase (ALT), or aspartate aminotransferase (AST). Additionally, these LNPs enhance the serum titers of IgG1 and IgG2a antibodies in mice.

6-Trehalose monooleate is a glycolipid employed in creating lipid nanoparticles (LNPs) for ex vivo delivery of immunosuppressants. In a tape-stripping test with isolated rabbit ear skin, LNPs with 6-trehalose monooleate encapsulating cyclosporin A predominantly accumulate in the stratum corneum rather than the epidermis and dermis. Additionally, 6-trehalose monooleate serves as an anti-aggregation agent for proteins.

Poly(styrenyl acetal trehalose) (pSAT) is synthesized by linking trehalose side chains to a polystyrene backbone through acetal bonds. This compound stabilizes various proteins and enzymes against temperature fluctuations without triggering an innate immune response. Additionally, Poly(styrenyl acetal trehalose) can be utilized in synthesizing protein-polymer conjugates, thereby reducing the renal clearance of active molecules.

Alpha,Beta-Trehalose-13C12 is a 13C-labelled form of D- (+)-Trehalose dihydrate. This trehalose dihydrate can be extracted from [Saccharomyces cerevisiae] and is utilized as a food ingredient and an excipient for active molecules.

Trehalose-6-phosphate hydrolase, Escherichia coli (EC 3.2.1.93), is a member of the hydrolase family, functioning as a glycosidase that hydrolyzes O- and S-glycosyl compounds. This enzyme plays a role in the metabolism of starch and sucrose, with substrates α,α-trehalose-6-phosphate and water, producing D-glucose and D-glucose-6-phosphate.

Trehalose-6-phosphate hydrolase, also known as Bacillus subtilis (EC 3.2.1.93), is part of the hydrolase enzyme family specializing in the hydrolysis of O- and S-glycosidic compounds. It plays a role in the metabolism of starch and sucrose. The substrates for this enzyme are α,α'-trehalose-6-phosphate and water, producing D-glucose and D-glucose-6-phosphate as products.

Trehalose 6,6'-dimycolate (Cord Factor) is a cell wall glycolipid from Mycobacterium tuberculosis. It can simulate the inflammation and granuloma typical of Mycobacterium tuberculosis (MTB) infection. Additionally, Trehalose 6,6'-dimycolate shields Mycobacterium tuberculosis against macrophage-mediated eradication, inhibits effective antigen presentation, and diminishes the development of protective T cell responses [1] [2].

D-(+)-Trehalose-D14is the deuterated form of D- (+)-Trehalose (TMSM-0853). This compound can be isolated from Saccharomyces cerevisiae and is commonly utilized as a food ingredient and an excipient for active molecules.

D-(+)-Trehalose dihydrate (Standard) is the standard substance of D-(+)-Trehalose dihydrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. D-(+)-Trehalose dihydrate (α,α-Trehalose dihydrate) is a natural α-linked disaccharide formed by an α, α-1, 1-glucoside bond between two α-glucose units.

Trimethylsilyl-D-(+)-trehalose is a reagent used in biochemical reactions.

Hypertrehalosemic neuropeptide (Nauphoeta cinerea), a member of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family, stimulates trehalose synthesis [1].

Lentztrehalose A, a disaccharide microbial metabolite identified in Lentzea, exhibits a range of biological activities. This compound specifically inhibits M. smegmatis trehalase—an enzyme involved in trehalose metabolism—more effectively than trehalase from porcine kidney, with IC50 values of 0.67 mM and >20 mM, respectively. Additionally, Lentztrehalose A at a concentration of 100 mM promotes autophagy in MeWo melanoma and OVK18 ovarian cancer cells. When administered at 50 mg/kg daily, it enhances survival rates and impedes tumor growth in a Sarcoma 180 murine sarcoma model.