tp353

TP-353 (EOS-61973) is a CDK7 inhibitor.

KSL 128114 is a syntenin peptide inhibitor that binds to the PDZ1 domain of syntenin with nanomolar affinity. It is resistant to degradation in human plasma and rat liver microsomes and exhibits selectivity for the PDZ domain of syntenin.

MYBMIM is an inhibitor of the MYB:CBP/P300 assembly complex [MYB:CBP/P300]. It suppresses the growth of leukemia cells.

Tat-βsyn-degron is an α-synuclein (α-synuclein) knockdown peptide that efficiently degrades the α-synuclein protein via the proteasome pathway. It effectively reduces α-synuclein protein levels in primary rat cortical neuron cultures. In Parkinson's mouse toxicity models, Tat-βsyn-degron alleviates neuronal damage and motor dysfunction induced by Parkinsonian toxins.

K90-114TAT is an inhibitor of the EAG2-Kvβ2 interaction, exhibiting antitumor activity against glioblastoma.

Brevicidine analog 22 (22) exhibits broad-spectrum antimicrobial activity and demonstrates excellent stability (t1/2 = 40.98 h), with a minimum inhibitory concentration (MIC) of 2-16 μM against both Gram-negative and Gram-positive bacteria.

SAAP 148 is an antimicrobial and antibiofilm agent that demonstrates inhibitory activity against antibiotic-resistant pathogens, with an LC50 of 0.8-12.8 μM.

Kiss2 peptide functions as a positive regulator of reproductive behavior. In COS-7 cells, it binds to its homologous G-protein coupled receptor Kiss2R (GPR54), activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).

T100-Mut is a cell-penetrating peptide that penetrates and targets the inner side of the cytoplasmic membrane by binding its N-terminus to a myristoyl group, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-related pain.

Ac-VAD-AFC serves as a fluorescent substrate for caspases and is utilized to assess caspase activity.

S1H is an analog of human growth hormone (hGH) and acts as an antagonist to the human growth hormone receptor (hGHR). It inhibits the interaction between hGH and hGHR and prevents the phosphorylation of STAT5 in cells treated with hGH.