tea

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.

Inosinic acid-13C5 (5'-IMP-13C5) TEA is a 13C-labeled version of inosinic acid. It is an endogenous metabolite commonly used as a food flavor enhancer and as a feed supplement to improve the yield and quality of pork.

Lamivudinetriphosphate (3TCTP) TEA is a phosphorylated form of Lamivudine, a nucleoside analogue. It inhibits the reverse transcriptase of the HIV or HBV virus, preventing viral replication through chain termination. Additionally, Lamivudine triphosphate TEA is an inhibitor of RdRp activity in the HCV NS5B subunit. It can also be incorporated into nascent RNA by SARS-CoV-2 RdRp, thereby halting mutations in new SARS-CoV-2 RNA.

Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and cross-infections.

Quercetin-3'-o-phosphate TEA (Quercetin 3'-phosphate TEA) is an adenosine A receptor antagonist that can be used to prevent and treat metabolic disorders.

Carba-NAD TEA is a NAD derivative that acts as a competitive inhibitor of calf splenic NAD+ hydrolase.

Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number

Tenofovir diphosphate TEA (TFV-DP TEA) is the triethylamine salt of TFV-DP, an ATP-competitive DNA polymerase inhibitor that inhibits HIV-1 reverse transcriptase. It has anti-HIV/HBV potential through its incorporation into the viral DNA strand to terminate viral DNA synthesis and thus inhibit viral genome replication.

MST-312 (Telomerase Inhibitor IX) is a derivative of green tea epigallocatechin gallate (EGCG). MST-312 is a telomerase inhibitor. MST-312 has research value in cancer, such as multiple myeloma (MM).

(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor.

Terpinen-4-ol (4-Carvomenthenol) is a natural compound derived from Pimpinella yunnanensis.

1-Ethyl-1H-Pyrrole-2-Carbaldehyde is an organic compound employed in the synthesis of diverse chemical entities including biologically active compounds, fluorescent dyes, and agrochemicals.

Triethanolamine oleate is a nonionic surfactant

Rp-cAMPS TEA salt is a cAMP-dependent protein kinase (PKA) activator.

Theaflavin digallate and lactic acid together could reduce herpes simplex virus transmission.

Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.

Met-AMS TEA (compound 50) is an aminosulfonate analog of methionyl adenosylsulfate, effectively inhibiting Escherichia coli methionyl-tRNA synthetase (MetRS) with an IC50 of 7 nM.

Glu-AMS TEA acts as a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), exhibiting a Ki of 2.8 nM.

Sulfo DBCO-PEG4-Maleimide (TEA) is a PROTAC linker that falls under the PEG class. It is utilized in the synthesis of PROTAC molecules. Additionally, Sulfo DBCO-PEG4-Maleimide (TEA) serves as a click chemistry reagent, containing a DBCO group that undergoes a strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

TLR4 agonist-1 (TEA, compound 17a) is a potent activator of Toll-like Receptor 4 (TLR4) and prompts the production of MIP-1β in RAW 264.7 and MM6 cells [1].

5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate TEA is a monomer used in nucleic acid synthesis.

2'F-DMTr-A(Bz)-SA (TEA) is a monomer material suitable for nucleic acid synthesis.

UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.

7-Deaza-7-propargylamino-dATP TEA is an analog of deoxyadenosine triphosphate (dATP) and is utilized in gene sequencing.