target/p53/4

p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.

GSNKGAIIGLM(131602-53-4(free base)) (Amyloid beta-peptide(25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.

4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

[D-Pro4,D-Trp7,9,10] Substance P (4-11) serves as a potent antagonist of the tachykinin family of neuropeptides [1].

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1].

Tripelargonin is a triacylglycerol that contains nonanoic acid at the sn-1, sn-2, and sn-3 positions. It has been found in Schizochytrium biomass.1 Tripelargonin increases blood levels of the ketone body D-(-)-3-hydroxybutyrate in newborn rhesus monkeys.2

4''-O-trans-p-Coumaroylafzelin is a natural product for research related to life sciences. The catalog number is TN6121 and the CAS number is 623927-14-0.

[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cultured cells or diseased vessels.

Substance P(1-4) acts as a potent antagonist of neurokinin receptors (NK-R) and regulates normal hematopoiesis, additionally inhibiting the formation of endogenous erythroid colonies (EEC) [1].

N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) acts as an agonist for lysosomal acid α-glucosidase (GAA). It dose-dependently enhances intracellular GAA activities in Pompe disease patient fibroblasts harboring the M519V mutation [1].

4-O-D-Glucopyranosyl-p-coumaric acid is a useful organic compound for research related to life sciences. The catalog number is T126288 and the CAS number is 117405-49-9.

2'',4''-Di-O-(Z-p-coumaroyl)afzelin is a natural product for research related to life sciences. The catalog number is TN2712 and the CAS number is 205534-17-4.

Butyraldehyde, 4-(p-aminophenoxy)-, diethyl acetal is a bioactive chemical.

(p-Iodo-Phe7)-ACTH (4-10), a derivative of adrenocorticotrophic hormone (ACTH) produced by the anterior pituitary gland, functions as a melanocortin (MC) receptor antagonist. It effectively inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats [1].

Substance P (4-11), a C-terminal fragment of Substance P, acts as a highly selective agonist for NK1 receptors, demonstrating specificity in its interaction.

[Sar4] Substance P (4-11) is a Substance P agonist and an analog of the C-terminus fragment of Substance P, known as Substance P (4-11) [1].

Ammonium, (4-(p-ethyldimethylammoniophenyl)butyl)ethyldimethyl-, diiodide can be used in related research in the field of life sciences. Its product number is T30012 and CAS number is 63981-94-2.

Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside is a natural product for research related to life sciences. The catalog number is TN6304 and the CAS number is 71781-79-8.

m-Toluidine, alpha-((p-chlorophenyl)sulfonyl)-4-(octyloxy)- is a bioactive chemical.

4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile is a useful organic compound for research related to life sciences and the catalog number is T66379.

4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T64550 and the CAS number is 1061214-06-9.

[DAla4] Substance P (4-11), an analog of Substance P (Substance P), effectively inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin) and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively [1].

Antimicrobial agent.

rel-MDM2/4-p53-IN-3 is an MDM2/4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2/4-p53-IN-3 can be used to study cancers, such as colon cancer.

m-Anisidine, 4-((5-p-tolylpentyl)oxy)- is a Drug / Therapeutic Agent.

Acetophenone, 4'-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical.

Acetanilide, 4'-(5-(p-(dimethylamino)phenoxy)pentyloxy)-N-ethyl- is a bioactive chemical.

4-(p-Biphenylyl)-3-hydroxybutyric acid is a useful organic compound for research related to life sciences and the catalog number is T124405.

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

Benzamide, N-(4-(p-aminophenoxy)butyl)- is a bioactive chemical.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-2-O-acetyl-5-(O-p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1038.

Super-chelating agent & MRI contrast agent

Nucleoside Derivatives - 2’-Modified nucleosides, 7-Deaza-purine nucleosides, Halo-nucleosides

4-Chloro-5-iodo-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1024.

3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin is a natural product for research related to life sciences. The catalog number is TN2871 and the CAS number is 349545-02-4.

P-gp inhibitor 4 is a selective P-glycoprotein modulator with an EC 50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells .

m-Anisidine, 4-((5-(p-nitrophenyl)pentyl)oxy)- is a bioactive chemical.

Ammonium, (4-(p-trimethylammoniophenyl)butyl)trimethyl-, diiodide is a bioactive chemical.

4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1021.

2,3,5-Tri-O-(p-toluoyl)-1-O-acetyl-4-thio-D-ribofuranose is a Carbohydrate Derivative.

H-D-Ser(tBu)-OH is an amino acid derivative and has a wide range of applications in life science related research.

Nucleoside Derivatives - 7-Deaza-8-aza-purine nucleosides; 6-Modified purine nucleosides

Glycolanilide, 4'-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical.

3'',4''-Di-O-p-coumaroylquercitrin is a natural product for research related to life sciences. The catalog number is TN5487 and the CAS number is 437615-43-5.

m-Anisidine, 4-((5-((p-chlorophenyl)thio)pentyl)oxy)- is a bioactive chemical.

Substance P (1-4) is a substance P N-terminal tetrapeptide fragment.

MDM2/4-p53-IN-2 (2q) is a potent dual inhibitor of MDM2/MDM4 and activator of p53, demonstrating IC50 values of 70.7 nM for MDM2-p53 and 81.4 nM for MDM4-p53 complexes. It facilitates cell cycle regulation, promotes apoptosis, and exhibits anticancer properties [1].

MDM2/4-p53-IN-3, an inhibitor of MDM2/4-p53 protein-protein interactions (PPIs), exhibits potent activity with IC50 values of 18.5 nM for MDM2-p53 and 14.8 nM for MDM4-p53. This compound is applicable in cancer research, including studies on colon cancer [1].

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist that effectively inhibits the actions of gold-protein-substance P (GPSP) and substance P (SP), demonstrating its efficacy in neutralizing their effects [1].

m-Toluidine, 4-(octyloxy)-alpha-(p-tolylsulfonyl)- is a bioactive chemical.