substrate

(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).

MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.

Sakamototide substrate peptide acetate is a peptide substrate of AMPK kinase family and can be used for the determination of kinase activity.

Calcineurin substrate acetate is from the regulatory RII subunit of cAMP-dependent protein kinase.

Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-coupled receptors, tyrosine Kinase recept

Phospho-Glycogen Synthase Peptide-2, a substrate for glycogen synthase kinase-3 (GSK-3), serves as a peptide substrate effective in the affinity purification of protein-serine kinases.

Renin FRET Substrate I is a specific compound designed to function as a substrate for human renin, containing the exact cleavage site found in the N-terminal peptide of human angiotensinogen.

Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety. Enteropeptidase is a serine protease expressed in the proximal small intestine of higher animals that converts inactive trypsinogen to active trypsin by endoproteolytic cleavage. Enteropeptidase recognizes the highly specific amino acid sequence DDDDK on the fluorogenic substrate and cleaves after the lysine residue, releasing the AFC moiety. Enteropeptidase activity is quantified by fluorescent detection of AFC, which displays excitation/emission spectra of 380/500 nm.

[pThr3]-CDK5 Substrate is an effective phospho-Thr3 CDK5 substrate that is phosphorylated by CDK5 with a Km value of 6 µM [1].

S6 Kinase Substrate Peptide (32) is a peptide utilized to measure the activity of kinases that phosphorylate ribosomal protein S6, and it can also serve as a substrate.

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG), showing a strong preference for PKG Iα (Km = 59 µM) over PKG II (Km = 305 µM).

Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.

PKA Regulatory Subunit II Substrate (RII phosphopeptide) is a tool peptide derived from the regulatory subunit Type II (RII) of cyclic adenosine monophosphate-dependent protein kinase (PKA). It is commonly used to simulate the phosphorylation activity of protein kinases and to assess the activity of protein phosphatases by serving as a specific substrate.

HIV Protease Substrate 1 TFA, a fluorogenic substrate for HIV protease, facilitates the investigation of the enzyme's activity [1].

H1-7 (histone H1 phosphorylation site), a synthetic polypeptide, serves as a PKA substrate and demonstrates utility in various PKA substrate applications [1] [2].

DAPK Substrate Peptide TFA is a synthetic peptide used as a substrate for the enzyme death-associated protein kinase (DAPK), with a Michaelis constant (Km) of 9 μM [1].

Fluorescent HIV Substrate (HIV substrate)

PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) and includes Thr-431 [1].

EGF Receptor Substrate 2 (Phospho-Tyr5) is a biologically active peptide derived from an autophosphorylation site (Tyr 992 ) of epidermal growth factor receptor (EGFR).

Tyrosine Protein Kinase Substrate is a polypeptide molecule with the sequence RRLIEDNEYTARG.

[Val8] Renin Substrate Tetradecapeptide, rat is a polypeptide molecule with the sequence DRVYIHPVHLLYYS.

[Cys8] Renin Substrate Tetradecapeptide, rat is a polypeptide molecule with the sequence DRVYIHPCHLLYYS.

Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, demonstrating no activity towards cathepsins B, H, or L. This specificity renders it essential for routine assays and mechanistic studies focusing on cathepsins E and D[1].