spdp

SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11

LC-PEG8-SPDP is a cleavable ADC linker utilized in antibody-drug conjugates (ADCs) [1].

SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.

SPDP-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG4-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, facilitating selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

SPDP-PEG6-NHS ester is a PEG-based linker for PROTACs, connecting two essential ligands crucial for PROTAC formation and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

PC SPDP-NHS carbonate ester is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

PEG4-SPDP, a cleavable ADC linker, is utilized in antibody-drug conjugates (ADCs).

SPDP-C6-Gly-Leu-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is used for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG24-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, which enables selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG24-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules for selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG36-NHS ester is a cleavable PEG ADC linker composed of 36 units, essential for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG5-acid is a PEG-based linker for PROTACs, connecting two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

SPDP-PEG7-acid is a PEG-based linker for PROTACs [Proteolysis-Targeting Chimeras] that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

SPDP-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties.

Sulfo-SPDP-C6-NHS sodium is a sodium salt form of a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-sulfo is a cleavable linker vital in ADC synthesis. SPDP-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DSPE-SPDP, a phospholipid molecule, possesses the ability to form lipid bilayers in water, making it valuable for biochemical research [1].

Ald-PEG23-SPDP, a cleavable 23-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].

PLLA5000-PEG5000-SPDP is a polylactic acid derivative capable of forming micelles in water, and its SPDP moiety can react with thiols. It is useful for research in drug delivery.