spdp

SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11

LC-PEG8-SPDP is a cleavable ADC linker utilized in antibody-drug conjugates (ADCs) [1].

SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.

SPDP-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG4-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, facilitating selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

SPDP-PEG6-NHS ester is a PEG-based linker for PROTACs, connecting two essential ligands crucial for PROTAC formation and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

PC SPDP-NHS carbonate ester is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

PEG4-SPDP, a cleavable ADC linker, is utilized in antibody-drug conjugates (ADCs).

SPDP-C6-Gly-Leu-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is used for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG24-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, which enables selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG24-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules for selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG36-NHS ester is a cleavable PEG ADC linker composed of 36 units, essential for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG5-acid is a PEG-based linker for PROTACs, connecting two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

SPDP-PEG7-acid is a PEG-based linker for PROTACs [Proteolysis-Targeting Chimeras] that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

SPDP-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties.

Sulfo-SPDP-C6-NHS sodium is a sodium salt form of a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-sulfo is a cleavable linker vital in ADC synthesis. SPDP-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DSPE-SPDP is a reactive phospholipid molecule. In aqueous environments, DSPE-SPDP can orient itself to form lipid bilayers or participate in the construction of lipid nanoparticles (LNPs). The SPDP functional group possesses disulfide exchange activity, allowing for the covalent conjugation of sulfhydryl-containing (-SH) biomolecules, such as antibodies, peptides, or siRNAs, to the surface of nanocarriers under physiological conditions.

Ald-PEG23-SPDP, a cleavable 23-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].

PLLA5000-PEG5000-SPDP is a polylactic acid derivative capable of forming micelles in water, and its SPDP moiety can react with thiols. It is useful for research in drug delivery.