skov

HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability.

D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.

MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.

AZ2, a potent PI3Kγ inhibitor (pIC50 value: 9.3), is primarily utilized in the investigation of inflammatory and immune diseases[1].

Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Anticancer agent 40 (compound 3e) is a potent anticancer agent with effects on SKBR-3 cells (IC50: 0.94 nM), SKOV-3 cells (IC50: 0.98 nM), PC-3 cells (IC50: 0.96 nM), U-87 cells (IC50: 0.95 nM), and HDF cells (IC50: 2.13 nM).

Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.

PI3Kα-IN-15 is a powerful inhibitor of PI3Kα, exhibiting an IC₅₀ of 0.15 μM. It shows promising anti-proliferative effects, inhibiting the growth of SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 cell lines with respective IC₅₀ values of 26.6 μM, 7.9 μM, 32.1 μM, 17.7 μM, and 9.4 μM. This compound is useful for cancer research [1].

Anticanceragent 240 (compound 9b) is an 8-quinolinesulfonamide derivative with cytotoxic activity. It exhibits inhibitory effects on the Caco-2, SNB-19, A-549, and SKOV-3 cell lines, with IC50 values of 0.26, 0.38, 0.40, and 4.16 μM, respectively.

Agrimonolide, a compound derived from isocoumarins and found mainly in the herb Agrimonia pilosa Ledeb, has significant biological activity. agrimonolide exerts anti-inflammatory effects by inhibiting lipopolysaccharide (LPS)-induced activation of JAK-STATs and p38 MAPKs signaling pathways. Agrimonolide and its derivative, desmethyl agonolide, have been shown to be effective in increasing insulin-mediated glycogen levels in hepatocytes and may play a key role in regulating insulin-resistant HepG2 cells. agrimonolide exhibits inhibitory effects on cancer progression and induction of cell death and apoptosis by targeting SCD1 in ovarian cancer cells. In particular, Agrimonolide exhibited a dose-dependent inhibition of proliferation, migration and invasion of A2780 and SKOV-3 cells, while promoting apoptosis. The compound was also found to induce iron-mediated cell death while increasing reactive oxygen species (ROS) and total iron levels.Agrimonolide readily crosses the blood-brain barrier, suggesting its potential for therapeutic applications in neurological disorders.