sesquiterpene lactone

Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells

Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.

Artemisinin (Qinghaosu) is a natural product, a sesquiterpene lactone, derived from Artemisia annua. Artemisinin has anti-malarial activity, as well as neuroprotective and anti-tumor activity.

Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in RAW 264.7 macrophages by deactivating NF-κB.

Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.

Mevalonolactone is a sesquiterpene lactone known to inhibit calcineurin activity against p-Nitrophenyl phosphate, with an IC50 of 134.29 μM.

Acantholide is a Sesquiterpene lactone isolated from Acanthospermum glabratum.

Janerin is a sesquiterpene lactone.

Laserolide is a sesquiterpene lactone.

Leptocarpin is a sesquiterpene lactone extracted from Leptocarpha rivularis.

Leucanthanolide is a sesquiterpene lactone from Montanoa leucantha.

Linifolin A is a sesquiterpene lactone extracted from Helenium aromaticum.

Repin, a plant responsible for Parkinson-like disease in horses, is the principal sesquiterpene lactone extracted from Russian knapweed.

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.

Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.

Ambrosin is a sesquiterpene lactone and a potent NF-κβ inhibitor. It is currently being studied as a potential lead drug for Alzheimer disease therapeutics.

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

Tomentosin, a sesquiterpene lactone extracted from Caspian sea raspberry, has potential anti-inflammatory and anticancer activities, promoting apoptosis and inhibiting proliferation, migration and invasion of pancreatic cancer cells.

Transilin, a sesquiterpene lactone, can be isolated from the entire Lepisorus contortus (Christ) Ching plant [1].

Shizukanolide, a sesquiterpene lactone extracted from Chloranthus japonicus (Chloranthaceae), has a dehydro derivative that exhibits moderate antifungal activity [1].

Grosshemin (Grosshemine), a natural sesquiterpene lactone widely derived from a variety of plants (e.g. Centaurea spp.), has anticancer potential by inhibiting cell proliferation in human tumor cell lines (A549, SK-OV-3, SK-MEL-2, HCT15).