sesquiterpene lactone

Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells

Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.

Artemisinin (Qinghaosu) is a natural product, a sesquiterpene lactone, derived from Artemisia annua. Artemisinin has anti-malarial activity, as well as neuroprotective and anti-tumor activity.

Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in RAW 264.7 macrophages by deactivating NF-κB.

Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.

Mevalonolactone is a sesquiterpene lactone known to inhibit calcineurin activity against p-Nitrophenyl phosphate, with an IC50 of 134.29 μM.

Acantholide is a Sesquiterpene lactone isolated from Acanthospermum glabratum.

Janerin is a sesquiterpene lactone.

Laserolide is a sesquiterpene lactone.

Leptocarpin is a sesquiterpene lactone extracted from Leptocarpha rivularis.

Leucanthanolide is a sesquiterpene lactone from Montanoa leucantha.

Linifolin A is a sesquiterpene lactone extracted from Helenium aromaticum.

Repin, a plant responsible for Parkinson-like disease in horses, is the principal sesquiterpene lactone extracted from Russian knapweed.

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.

Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.

Ambrosin is a sesquiterpene lactone and a potent NF-κβ inhibitor. It is currently being studied as a potential lead drug for Alzheimer disease therapeutics.

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

Tomentosin, a sesquiterpene lactone extracted from Caspian sea raspberry, has potential anti-inflammatory and anticancer activities, promoting apoptosis and inhibiting proliferation, migration and invasion of pancreatic cancer cells.

Transilin, a sesquiterpene lactone, can be isolated from the entire Lepisorus contortus (Christ) Ching plant [1].

Thapsigargicin is a sesquiterpene lactone natural product isolated from the poisonous plant Thapsia garganica. Thapsigargicin is a potent non-competitive inhibitor of the sarcoplasmic reticulum/endoplasmic reticulum calcium ATPase (SERCA)(IC₅₀ ≈ 10–30 nM). By specifically blocking the SERCA pump, it depletes endoplasmic reticulum calcium stores and elevates cytoplasmic calcium levels, thereby activating mast cells and leukocytes to release histamine, inducing endoplasmic reticulum stress and apoptosis. Thapsigargicin can be used in studies of calcium signaling pathways and inflammatory responses.

Shizukanolide, a sesquiterpene lactone extracted from Chloranthus japonicus (Chloranthaceae), has a dehydro derivative that exhibits moderate antifungal activity [1].