rxfpreceptor

AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.

RXFP3/4 agonist 2 is a potent, non-peptidic bis-RXFP3/4 agonist that facilitates the interaction between RXFP3 and β-arrestin-2 and is useful for studying diseases caused by metabolic abnormalities.

RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats.RLX-33 can be used to study the metabolic syndrome.

RXFP3/4 agonist 1 is a relaxin family peptide 3/4 receptor (RXFP3/4) agonist(EC50s of 82/2 nM, respectivley).

Example 2 (RXFP1 receptor agonist-8) is a potent RXFP1 receptor agonist that suppresses cAMP production in HEK293 cells expressing human RXFP1, exhibiting an EC50 of 1.8 nM [1].

RXFP1 receptor agonist-7 (Example 2) is an RXFP1 receptor agonist that effectively inhibits cAMP production in HEK293 cells stably expressing the human RXFP1, with an EC50 of 4.2 nM [1].

RXFP1 receptor agonist-6 (Example 7) acts as an agonist for the RXFP1 receptor and effectively suppresses cAMP production in HEK293 cells stably expressing the human RXFP1, with an EC50 of 12 nM [1].

RXFP1 receptor agonist-5 (Example 98) is an agonist targeting the RXFP1 receptor, inhibiting cAMP production in HEK293 cells with stable human RXFP1 expression, with an EC50 of 1.3 nM [1].

RXFP1 receptor agonist-4 (Example 268) is a potent RXFP1 receptor agonist, shown to effectively suppress cAMP production in HEK293 cells stably expressing the human RXFP1 receptor, with an effective concentration (EC50) of 4.9 nM [1].

RXFP1 receptor agonist-3 (Example 223) is an RXFP1 receptor agonist that inhibits cyclic AMP (cAMP) production in HEK293 cells stably expressing human RXFP1, with an EC50 of 2 nM [1].

RXFP1 Receptor Agonist-2 (Example 124), an EC50 value of 1 nM [1].

RXFP1 receptor agonist-1 (Example 2), suppresses cAMP production in HEK293 cells constitutively expressing the human RXFP1, with an EC50 of 300 nM [1].

Relaxin H3 (human), a relaxin peptide, exhibits antifibrotic effects by activating RXFP1 [1].

Efranarelaxin alfa is an agonist of the relaxin receptor. It shows potential for research in cardiovascular diseases and tissue repair.