rc 1

Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.

RC 121 is a highly potent somatostatin (SRIF) analog.

RC 161 is a somatostatin octapeptide analog.

Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulation in mice when administered intradermally at doses ranging from 1 to 300 nmol/site, which is inhibited by the BB2 bombesin receptor agonist RC-3095 and reduced in mast cell-deficient mice. Neuromedin C (3.2 nmol/kg, i.p.) reduces rat glucose consumption by approximately 50% for up to one hour.

IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively). |1. Li, K., Liang, Z., Chen, W., et al. Iakyricidins A-D, antiproliferative piericidin analogues bearing a carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. J. Org. Chem. 84(19), 12626-12631 (2019).

RC-160 [Lys(Boc)], an 8-amino acid peptide, functions as a somatostatin analog [1].

Malonylginsenoside Rc, a naturally occurring active compound, exhibits anti-proliferative activity [1].

Bacteriopheophytin, a photosynthetic pigment found in bacteria, is a demetallated form of bacterial chlorophyll where the magnesium ion at the center is replaced by two hydrogen atoms. It functions as an electron acceptor within the reaction center (RC) of purple bacteria, playing a crucial role in the electron transfer process [1].

RC-106, a proteasome inhibitor (IC50: 35 μM) and Sigma receptor modulator, exhibits anticancer activity and antiproliferative effects against cancer cells, including glioblastoma (GB) and multiple myeloma (MM) [1].