quinone

Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.). Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.

6-Hydroxydopa-quinone-CoA (6-Hydroxydopa quinone-coenzyme A) is a derivative of coenzyme A.

During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also displayed antioxidant activities after it is reduced to tocopherylhydroquinone.

Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,

Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhanc

Hexazinone is a broad-spectrum herbicide from the triazine family. Hexazinone inhibits photosynthesis through binding to the D-1 quinone protein of the electron transport chain in photosystem II.

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation.

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor that disrupts CN-NFAT signaling by targeting the NFAT(P) substrate at the calcineurin (CN) phosphatase site.

Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.

S29434 (NMDPEF) is a potent, competitive inhibitor of quinone reductase 2 (QR2), with an IC50 range of 5-16 nM.

RhlR antagonist E22 is a quorum sensing modulator as an RhlR antagonist.

Cannabidiol hydroxyquinone (HU-331) is potentially an active metabolite of cannabidiol that could play a role in inducing apoptosis. It functions by inhibiting the ATPase activity of topoisomerase IIα through a noncompetitive mechanism.

CBGAQ, an analytical reference standard, is an oxidative quinone derivative of cannabigerolic acid (CBGA), designed for research and forensic applications.

2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.

HPPD-Q (HPPD-quinone) is a substituted p-benzoquinone and a derivative of 6-PPD-Q.

Estradiol3,4-quinone (E2-3,4-Q) is a metabolite of Estradiol. This compound is highly electrophilic and is capable of inducing mutations that can initiate cancer.

Tigecycline quinone analog-1 (Impurity 3) functions as an antioxidant and can be utilized in studies related to antioxidant research.

Nevirapine quinone methide is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

Coleon-U-quinone, a potent P-gp (P-glycoprotein) inhibitor, effectively reduces the viability of cancer cells and increases the sensitivity of multidrug-resistant cancer cells to Doxorubicin [1].

Coumarin–quinone conjugate, a fluorescent substrate for NADH:ubiquinone oxidoreductases, consists of a coumarin fluorophore and a ubiquinone analog. It can be utilized to measure the kinetic parameters of AIFM2/FSP1 in research related to ferroptosis [1].

2,5-dimethoxycyclohexa-2,5-diene-1,4-dio (Thermophillin) is a natural product. The redox cycle of 2,5-dimethoxybenzoquinone is a source of reducing equivalent for the regeneration of Fe2+ and H2O2 in brown rot fungal decay of wood.

1-bromo-5-hydroxyanthra-9,10-quinone is a useful organic compound for research related to life sciences and the catalog number is T131407.