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Search Result

Search Results for " pyruvate "

Targets

Reactive Oxygen Species Endogenous Metabolite

77

Compounds

17

Natural Products

29

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T7717 Sodium 2-oxopropanoate Sodium pyruvate Reactive Oxygen Species , Endogenous Metabolite
Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.
T32221 Isoniazid pyruvate NSC-97221,BRN 0185611,NSC97221,NSC 97221,L 1011
Isoniazid pyruvate is a metabolite of isoniazid. Isoniazid (Laniazid, Nydrazid), also known as isonicotinylhydrazine (INH), is an organic compound that is the first-line medication in prevention and treatment of tubercul...
T76143 Pyruvate oxidase
Pyruvate oxidase (PoxB), a thiamine pyrophosphate-dependent enzyme, performs the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide, and water. This enzyme plays a crucial role in bacterial metabol...
T76115 Pyruvate kinase
Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .
T80060 Pyruvate carboxylase Endogenous Metabolite
Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme is crucial for regulating whole-body energetics, influencing...
T61961 Pyruvate Carboxylase-IN-2
Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC). In cell lysate-based and cell-based PC activity assays, Pyruvate Carbo...
T60341 Pyruvate Carboxylase-IN-1
Pyruvate Carboxylase-IN-1 (compound 37), a natural analog of erianin, is a potent inhibitor of pyruvate carboxylase (PC), exhibiting inhibitory concentrations (IC50) of 0.204 μM and 0.104 μM in cell lysate-based and cell...
T12499 PKR-IN-2 PKM
PKR-IN-2 is a activator of pyruvate kinase (PKR).
T6816 DASA-58 PKM
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T4223 Mitapivat PKR-IN-1 PKM
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T1768 7ACC2 Mitochondrial Metabolism , Monocarboxylate transporter
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T11765 KPLH1130 Dehydrogenase , PDK
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.
T17224 VER-246608 Dehydrogenase , PDK
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...
T2447 AZD7545 Dehydrogenase
AZD7545 is a potent PDHK inhibitor.
T22350 JX06 Apoptosis , Dehydrogenase , PDK
JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
T31976 Glymidine sodium Others
Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.
T7214 TEPP-46 ML265 PKM
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .
T4170 PKM2-IN-1 PKM2 inhibitor,compound 3k PKM
PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T12412L PDK4-IN-1 hydrochloride Apoptosis , PDK
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)
T2607 MSDC 0160 CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 Others , IGF-1R , Mitochondrial Metabolism
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T19783 Dehydroabiethylamine NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine P450 , PDK
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.
T9235 GW604714X 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Mitochondrial Metabolism
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
T5882 3-Bromopyruvic acid Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid Apoptosis , Hexokinase , Autophagy
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu...
T7460 α-Cyano-4-hydroxycinnamic acid α-Cyano-4-hydroxycinnamic acid(α-CHCA) Monocarboxylate transporter
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
T78351 Phosphoenolpyruvate carboxylase PEPC
Phosphoenolpyruvate carboxylase (PEPC) is an enzyme that irreversibly catalyzes the conversion of phosphoenolpyruvate and bicarbonate to oxaloacetate and inorganic phosphorus in the presence of Mg2+. It is essential for ...
T69237 Phosphoenol-3-bromopyruvate
Phosphoenol-3-bromopyruvate is a mechanism-based inhibitor of phosphoenolpyruvate carboxylase from maize
T0745 Disodium monofluorophosphate Sodium Monofluorophosphate,NSC248 Phosphatase , PKM , Phosphorylase
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
T67900 PKM2 inhibitor G PKM
PKM2 inhibitor G is a inhibitor of pyruvate kinase.
T15944 M77976 PDK
M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.
T1546 Nitazoxanide NSC 697855 Others , Influenza Virus , Parasite , Autophagy
Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron tran...
T62758 PKM2 activator 2 PKM
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...
T38715 MSDC-0602K MSDC-0602K,Azemiglitazone potassium PPAR
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (...
T6157 Devimistat CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid Apoptosis , Dehydrogenase , Mitochondrial Metabolism
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...
T60102L Dimethylaminomicheliolide HCl PKM
Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations.
T4441 UK-5099 UK 5099,PF-1005023,UK5099 Others , Mitochondrial Metabolism
UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM) [1].
T8648 6-AZATHYMINE Nucleoside Antimetabolite/Analog , Influenza Virus , DNA/RNA Synthesis , Antibacterial
6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic...
T15362 FX-11 LDHA Inhibitor FX11 Dehydrogenase
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...
T22336 Galloflavin Dehydrogenase
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.
T0239 Lonidamine AF1890,DICA,Diclondazolic Acid Apoptosis , Hexokinase , Mitochondrial Metabolism
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
T4103 (L)-Sodium lactate Sodium L-Lactate Others
(L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small...
T29863 Algestone acetonide W3395,W-3395,17α-isopropylidenedioxyprogesterone,algestone 16α,17α-acetonide,W 3395
Pyruvate algebra stone (W-3395) is progesterone.
T69865 Mitapivat sulfate
Mitapivat sulfate, also known as AG-348 sulfate hydrate, is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T70665 PF-06284674
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.
T12412 PDK4-IN-1 Others
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM).
T39753 Etavopivat FT-4202
Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling.
T69677 Mitapivat sulfate anhydrous
Mitapivat sulfate anhydrous is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T12498 PKR activator 2 Others
PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).
T63012 TM-1
TM-1 is a potent pyruvate dehydrogenase kinase (PDHK) inhibitor that inhibits the activity of PDHK1 (IC50: 2.97 μM) and PDHK2 (IC50: 5.2 μM). TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation and inhibits...
T72900 Indolokine A4
Indolokine A4, a catabolite of indole-3-pyruvate (I3P), is a potent AhR agonist .
T76136 Tryptophanase
Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].

Compounds

Sodium 2-oxopropanoate
T7717
Synonym: Sodium pyruvate
Target: Reactive Oxygen Species, Endogenous Metabolite
Isoniazid pyruvate
T32221
Synonym: NSC-97221,BRN 0185611,NSC97221,NSC 97221,L 1011
Target:
Pyruvate oxidase
T76143
Synonym:
Target:
Pyruvate kinase
T76115
Synonym:
Target:
Pyruvate carboxylase
T80060
Synonym:
Target: Endogenous Metabolite
Pyruvate Carboxylase-IN-2
T61961
Synonym:
Target:
Pyruvate Carboxylase-IN-1
T60341
Synonym:
Target:
PKR-IN-2
T12499
Synonym:
Target: PKM
DASA-58
T6816
Synonym:
Target: PKM
Mitapivat
T4223
Synonym: PKR-IN-1
Target: PKM
7ACC2
T1768
Synonym:
Target: Mitochondrial Metabolism, Monocarboxylate transporter
KPLH1130
T11765
Synonym:
Target: Dehydrogenase, PDK
VER-246608
T17224
Synonym:
Target: Dehydrogenase, PDK
AZD7545
T2447
Synonym:
Target: Dehydrogenase
JX06
T22350
Synonym:
Target: Apoptosis, Dehydrogenase, PDK
Glymidine sodium
T31976
Synonym:
Target: Others
TEPP-46
T7214
Synonym: ML265
Target: PKM
PKM2-IN-1
T4170
Synonym: PKM2 inhibitor,compound 3k
Target: PKM
PDK4-IN-1 hydrochloride
T12412L
Synonym:
Target: Apoptosis, PDK
MSDC 0160
T2607
Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160
Target: Others, IGF-1R, Mitochondrial Metabolism
Dehydroabiethylamine
T19783
Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine
Target: P450, PDK
GW604714X
T9235
Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
Target: Mitochondrial Metabolism
3-Bromopyruvic acid
T5882
Synonym: Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid
Target: Apoptosis, Hexokinase, Autophagy
α-Cyano-4-hydroxycinnamic acid
T7460
Synonym: α-Cyano-4-hydroxycinnamic acid(α-CHCA)
Target: Monocarboxylate transporter
Phosphoenolpyruvate carboxylase
T78351
Synonym: PEPC
Target:
Phosphoenol-3-bromopyruvate
T69237
Synonym:
Target:
Disodium monofluorophosphate
T0745
Synonym: Sodium Monofluorophosphate,NSC248
Target: Phosphatase, PKM, Phosphorylase
PKM2 inhibitor G
T67900
Synonym:
Target: PKM
M77976
T15944
Synonym:
Target: PDK
Nitazoxanide
T1546
Synonym: NSC 697855
Target: Others, Influenza Virus, Parasite, Autophagy
PKM2 activator 2
T62758
Synonym:
Target: PKM
MSDC-0602K
T38715
Synonym: MSDC-0602K,Azemiglitazone potassium
Target: PPAR
Devimistat
T6157
Synonym: CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism
Dimethylaminomicheliolide HCl
T60102L
Synonym:
Target: PKM
UK-5099
T4441
Synonym: UK 5099,PF-1005023,UK5099
Target: Others, Mitochondrial Metabolism
6-AZATHYMINE
T8648
Synonym:
Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis, Antibacterial
FX-11
T15362
Synonym: LDHA Inhibitor FX11
Target: Dehydrogenase
Galloflavin
T22336
Synonym:
Target: Dehydrogenase
Lonidamine
T0239
Synonym: AF1890,DICA,Diclondazolic Acid
Target: Apoptosis, Hexokinase, Mitochondrial Metabolism
(L)-Sodium lactate
T4103
Synonym: Sodium L-Lactate
Target: Others
Algestone acetonide
T29863
Synonym: W3395,W-3395,17α-isopropylidenedioxyprogesterone,algestone 16α,17α-acetonide,W 3395
Target:
Mitapivat sulfate
T69865
Synonym:
Target:
PF-06284674
T70665
Synonym:
Target:
PDK4-IN-1
T12412
Synonym:
Target: Others
Etavopivat
T39753
Synonym: FT-4202
Target:
Mitapivat sulfate anhydrous
T69677
Synonym:
Target:
PKR activator 2
T12498
Synonym:
Target: Others
TM-1
T63012
Synonym:
Target:
Indolokine A4
T72900
Synonym:
Target:
Tryptophanase
T76136
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T8030 Ethyl pyruvate Apoptosis , Antioxidant
Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.
T0809 Dicoumarol Dicumarol Dehydrogenase , NADPH , PDK
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...
T3604 Sodium dichloroacetate Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA) Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...
T1125 Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid TNF , NF-κB , Chloride channel , HIV Protease , PKM
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.
T4891 Sodium phenylpyruvate Phenylpyruvic acid, sodium salt Others
Sodium phenylpyruvate (Phenylpyruvic acid, sodium salt) is a substrate for phenylpyruvate decarboxylase and phenylpyruvate tautomerase.
T4898 Potassium 1-carboxyvinyl hydrogenphosphate PEP-K,Phospho(enol)pyruvic acid monopotassium Others , Endogenous Metabolite
Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of arom...
T8363 DL-Serine PKM
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
T5213 Acetyl phosphate(lithium potassium) Lithium potassium acetyl phosphate,Acetylphosphoric acid Others , Endogenous Metabolite
Acetyl phosphate lithium potassium (Lithium potassium acetyl phosphate) is a compound involved in taurine and hypotaurine metabolism as well as pyruvate metabolism. Acetyl phosphate lithium potassiu is generated from sul...
T4929 L-2-Phosphoglyceric acid L-2-Phosphoglyceric acid disodium salt h Others , Endogenous Metabolite
L-2-Phosphoglyceric acid (L-2-Phosphoglyceric acid disodium salt) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultima...
T4811 D-Alanine D-α-Alanine,Ba 2776,(R)-Alanine,(R)-2-Aminopropionic acid Chloride channel , Endogenous Metabolite
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory...
T4838 (S)-Malic acid L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid Others , Endogenous Metabolite
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic a...
T19365 Hydroxypyruvic acid 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid Others
Hydroxypyruvic acid is an intermediate in the metabolism of glycine, serine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.
T60581 Alkannin
Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1].
T16837 SAICAR Others
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).
TN2181 Sarmentosin Others
Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum gluta...
T82365 Fulvotomentoside B
Fulvotomentoside B, a saponin derived from Lactobacillus flavus, displays hepatoprotective properties. It notably decreases serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) concentrations in mice sub...
T5141 L-2-Phosphoglyceric acid disodium salt hydrate Others
L-2-Phosphoglyceric acid disodium salt is a glyceric acid which serves as the substrate in glycolysis. It is catalyzed by enolase into phosphoenolpyruvate.

Natural Products

Ethyl pyruvate
T8030
Synonym:
Target: Apoptosis, Antioxidant
Dicoumarol
T0809
Synonym: Dicumarol
Target: Dehydrogenase, NADPH, PDK
Sodium dichloroacetate
T3604
Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)
Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK
Shikonin
T1125
Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid
Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM
Sodium phenylpyruvate
T4891
Synonym: Phenylpyruvic acid, sodium salt
Target: Others
Potassium 1-carboxyvinyl hydrogenphosphate
T4898
Synonym: PEP-K,Phospho(enol)pyruvic acid monopotassium
Target: Others, Endogenous Metabolite
DL-Serine
T8363
Synonym:
Target: PKM
Acetyl phosphate(lithium potassium)
T5213
Synonym: Lithium potassium acetyl phosphate,Acetylphosphoric acid
Target: Others, Endogenous Metabolite
L-2-Phosphoglyceric acid
T4929
Synonym: L-2-Phosphoglyceric acid disodium salt h
Target: Others, Endogenous Metabolite
D-Alanine
T4811
Synonym: D-α-Alanine,Ba 2776,(R)-Alanine,(R)-2-Aminopropionic acid
Target: Chloride channel, Endogenous Metabolite
(S)-Malic acid
T4838
Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid
Target: Others, Endogenous Metabolite
Hydroxypyruvic acid
T19365
Synonym: 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid
Target: Others
Alkannin
T60581
Synonym:
Target:
SAICAR
T16837
Synonym:
Target: Others
Sarmentosin
TN2181
Synonym:
Target: Others
Fulvotomentoside B
T82365
Synonym:
Target:
L-2-Phosphoglyceric acid disodium salt hydrate
T5141
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (10)
Mouse (10)
E. coli (4)
Rat (4)
Entamoeba histolytica (1)
Expression System：
E. coli (19)
Baculovirus-Insect Cells (5)
Baculovirus (2)
HEK293 (2)
in vitro E. coli expression system (1)
Tag：
His (10)
N-terminal 6xHis-tagged (5)
N-terminal 10xHis-tagged (4)
N-terminal 6xHis-SUMO-tagged (3)
N-6His (2)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
C-6His (1)
C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) (1)
His,GST (1)
Cat No. Product Name Species Expression System
TMPY-04445 PDK4 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient...
TMPY-01100 GPT2 Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and pla...
TMPH-02625 DLAT Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
TMPY-04568 PDK1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantl...
TMPY-01099 GPT Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfa...
TMPH-02626 DLAT Protein, Mouse, Recombinant (His) Mouse HEK293
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
TMPY-04765 PKLR Protein, Human, Recombinant (His) Human E. coli
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPY-04766 PKM2 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ...
TMPY-04465 PKM2 Protein, Human, Recombinant (His) Human E. coli
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ...
TMPJ-00955 MDH1 Protein, Human, Recombinant (His) Human E. coli
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate...
TMPH-00710 PEP synthase Protein, E. coli, Recombinant (His & SUMO) E. coli E. coli
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
TMPH-00602 MetC Protein, E. coli, Recombinant (His) E. coli E. coli
Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. Also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine. In addition, under c...
TMPH-02469 PDK1 Protein, Mouse, Recombinant (His) Mouse Baculovirus
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, a...
TMPJ-00797 LDHB Protein, Human, Recombinant (His) Human E. coli
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD...
TMPH-00693 L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His) E. coli E. coli
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
TMPH-00515 PPDK Protein, Entamoeba histolytica, Recombinant (His & SUMO) Entamoeba histolytica E. coli
Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis.
TMPH-02686 GLXR Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
TMPH-00722 PykF Protein, E. coli, Recombinant (His) E. coli E. coli
Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis.
TMPH-01696 SLC16A4 Protein, Human, Recombinant (His) Human E. coli
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine...
TMPH-02470 PDK3 Protein, Mouse, Recombinant (His) Mouse E. coli
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and incre...
TMPY-04773 TPK1 Protein, Human, Recombinant (His) Human E. coli
Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism d...
TMPJ-00724 LDHA Protein, Human, Recombinant (His) Human E. coli
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,...
TMPY-02288 Glyoxalase II/HAGH Protein, Human, Recombinant (His) Human E. coli
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase an...
TMPY-04241 LDHA Protein, Rat, Recombinant (His) Rat E. coli
LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA, a key enzyme r...
TMPY-00010 LDHA Protein, Mouse, Recombinant (His) Mouse E. coli
LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA, a key enzyme r...
TMPH-02871 PKM2 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines w...
TMPH-02872 PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines w...
TMPH-03256 CNR1 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...
TMPH-01035 CNR1 Protein-VLP, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
PDK4 Protein, Mouse, Recombinant (His & GST)
TMPY-04445
Species: Mouse
Expression System: Baculovirus-Insect Cells
GPT2 Protein, Rat, Recombinant (His)
TMPY-01100
Species: Rat
Expression System: Baculovirus-Insect Cells
DLAT Protein, Mouse, Recombinant (E. coli, His)
TMPH-02625
Species: Mouse
Expression System: E. coli
PDK1 Protein, Human, Recombinant (His)
TMPY-04568
Species: Human
Expression System: Baculovirus-Insect Cells
GPT Protein, Rat, Recombinant (His)
TMPY-01099
Species: Rat
Expression System: Baculovirus-Insect Cells
DLAT Protein, Mouse, Recombinant (His)
TMPH-02626
Species: Mouse
Expression System: HEK293
PKLR Protein, Human, Recombinant (His)
TMPY-04765
Species: Human
Expression System: E. coli
PKM2 Protein, Mouse, Recombinant (His)
TMPY-04766
Species: Mouse
Expression System: Baculovirus-Insect Cells
PKM2 Protein, Human, Recombinant (His)
TMPY-04465
Species: Human
Expression System: E. coli
MDH1 Protein, Human, Recombinant (His)
TMPJ-00955
Species: Human
Expression System: E. coli
PEP synthase Protein, E. coli, Recombinant (His & SUMO)
TMPH-00710
Species: E. coli
Expression System: E. coli
MetC Protein, E. coli, Recombinant (His)
TMPH-00602
Species: E. coli
Expression System: E. coli
PDK1 Protein, Mouse, Recombinant (His)
TMPH-02469
Species: Mouse
Expression System: Baculovirus
LDHB Protein, Human, Recombinant (His)
TMPJ-00797
Species: Human
Expression System: E. coli
L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His)
TMPH-00693
Species: E. coli
Expression System: E. coli
PPDK Protein, Entamoeba histolytica, Recombinant (His & SUMO)
TMPH-00515
Species: Entamoeba histolytica
Expression System: E. coli
GLXR Protein, Mouse, Recombinant (His & SUMO)
TMPH-02686
Species: Mouse
Expression System: E. coli
PykF Protein, E. coli, Recombinant (His)
TMPH-00722
Species: E. coli
Expression System: E. coli
SLC16A4 Protein, Human, Recombinant (His)
TMPH-01696
Species: Human
Expression System: E. coli
PDK3 Protein, Mouse, Recombinant (His)
TMPH-02470
Species: Mouse
Expression System: E. coli
TPK1 Protein, Human, Recombinant (His)
TMPY-04773
Species: Human
Expression System: E. coli
LDHA Protein, Human, Recombinant (His)
TMPJ-00724
Species: Human
Expression System: E. coli
Glyoxalase II/HAGH Protein, Human, Recombinant (His)
TMPY-02288
Species: Human
Expression System: E. coli
LDHA Protein, Rat, Recombinant (His)
TMPY-04241
Species: Rat
Expression System: E. coli
LDHA Protein, Mouse, Recombinant (His)
TMPY-00010
Species: Mouse
Expression System: E. coli
PKM2 Protein, Mouse, Recombinant (His & Myc)
TMPH-02871
Species: Mouse
Expression System: Baculovirus
PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc)
TMPH-02872
Species: Mouse
Expression System: E. coli
CNR1 Protein, Rat, Recombinant (His)
TMPH-03256
Species: Rat
Expression System: in vitro E. coli expression system
CNR1 Protein-VLP, Human, Recombinant (His)
TMPH-01035
Species: Human
Expression System: HEK293
Cat No. Product Name
L2520 Glycometabolism Compound Library

708 compounds
708 glycometabolism-related comounds, can be used for HTS and HCT;
L2521 Glycolysis Compound Library

560 compounds
560 glycolysis-related active compounds for high-throughput and high-content screening.
L2501 Human Endogenous Metabolite Compound Library Plus

1300 compounds
A unique collection of 1300 endogenous metabolism-related compounds for research in endogenous metabolism-related diseases and drug screening.

Libraries

Glycometabolism Compound Library
L2520
Compounds: 708
Glycolysis Compound Library
L2521
Compounds: 560
Human Endogenous Metabolite Compound Library Plus
L2501
Compounds: 1300
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