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Results for "

polymerase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    495
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    TargetMol | Inhibitors_Agonists
Foscarnet sodium
Phosphonoformate
T022063585-09-1
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
  • $41
In Stock
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Ganciclovir
RS-21592, BW 759, 2'-Nor-2'-deoxyguanosine
T068882410-32-0
Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
  • $51
In Stock
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Floxuridine
NSC 27640, FUDR, Deoxyfluorouridine, 5-Fluorouracil 2'-deoxyriboside
T096450-91-9
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
  • $30
In Stock
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Acyclovir
Acycloguanosine, Aciclovir
T145459277-89-3
Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.
  • $39
In Stock
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Isosteviol
(-)-Isosteviol
T333227975-19-5
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressure, anti-inflammation, anti-tumor, anti-diarrhea, antibacterium, immunoregulation, etc.
  • $41
In Stock
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Clevudine
L-FMAU, Levovir
T6446163252-36-6
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
  • $39
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Neobavaisoflavone
T6S013941060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production
  • $40
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Nudifloramide
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
T8150701-44-0
Phytic acid dipotassium salt is an endogenous metabolite that inhibits β-secretase 1 (BACE1).
  • $29
In Stock
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TargetMol | Inhibitor Sale
IMT1
Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-, LDC195943(IMT1)
T88412304621-31-4
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
  • $74
In Stock
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DNA polymerase-IN-1
T80644809234-33-1In house
DNA polymerase-IN-1, a DNA polymerase inhibitor, exhibited antiproliferative activity against tumor cells with a half-inhibitory concentration (IC50) of 20.7 μM. DNA polymerase-IN-1 inhibited Taq DNA polymerase with an IC50 of less than 250 μM. DNA polymerase-IN-1 was shown to inhibit Taq DNA polymerase by RT- DNA polymerase-IN-1 showed antiretroviral activity in vitro by RT-PCR assay and can be used to study oxidative damage and colorectal cancer.
  • $195 TargetMol
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DNA polymerase-IN-6
T2042842701561-91-1
DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.
  • Inquiry Price
10-14 weeks
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HCV NS5B polymerase-IN-2
T204671438476-59-6
HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.
  • Inquiry Price
10-14 weeks
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RNA polymerase II-IN-1
T746302891451-07-1
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM and exhibits heightened cytotoxicity towards cancer cells while reducing toxicity in normal cells compared to α-Amanitin [1].
  • Inquiry Price
8-10 weeks
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RNA polymerase II-IN-2
T74631
RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, exhibits cytotoxicity against cancer cells, demonstrating toxicity levels 2 and 5 times higher than α-amanitin in CHO and HEK293 cells, respectively [1].
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Viral polymerase-IN-1 hydrochloride
T747652367587-02-6
Viral polymerase-IN-1 hydrochloride, a derivative of Gemcitabine, effectively inhibits influenza A and B virus infections with IC90 values between 11.4 and 15.9 μM, and shows activity against SARS-CoV-2 infection by interfering with viral RNA replication transcription within cells [1].
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DNA polymerase-IN-2
T79307
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, inhibits Taq DNA polymerase with an IC50 value of 48.25 μM and shows potential for value-added disease research [1].
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DNA polymerase-IN-3
T79308381689-75-4
DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, inhibits Taq DNA polymerase and shows potential applications in proliferative disease research [1].
  • Inquiry Price
8-10 weeks
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Taq DNA polymerase
T799222304873-37-6
Taq DNA polymerase, a thermostable enzyme, is utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].
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T7 RNA polymerase
T799239014-24-8
T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects only DNA templates that contain the T7 promoter sequence, whether single-stranded or double-stranded. It employs NTPs to synthesize RNA that is complementary to the single-stranded DNA following the promoter [1] [2].
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Poly(A) polymerase
T799269026-30-6
Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP. This modification enhances RNA stability and augments mRNA translation efficiency in eukaryotic cells, evidencing the enzyme's high tailing efficiency [1] [2].
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DNA polymerase-IN-4
T82536
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, demonstrates antiretroviral activity with an IC50 of 134.22 μM [1].
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RNA polymerase-IN-1
T873372447106-74-1
RNA polymerase-IN-1 (compound 4) acts as an inhibitor of DNA-dependent RNA polymerase. Additionally, it inhibits CYP isozymes [1].
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RNA polymerase-IN-2
T873382447106-79-6
RNA polymerase-IN-2 (compound 5) acts as an inhibitor of DNA-dependent RNA polymerase. Additionally, it inhibits CYP isozymes [1].
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DNA polymerase-IN-5
T89367
DNA polymerase-IN-5 (compound 42) is a broad-spectrum antiviral agent effective against herpesviruses. It exhibits inhibitory activity against CMV and VZV with IC50 values of 6.6 μM and 4.8 μM, respectively.
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