ovcar-3

3-arylisoquinolinamine derivative is a compound with antitumor activity.

C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO.

KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.

KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.

NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypo

(+)-δ-Cadinene is a sesquiterpene from G. hirsutum with antibacterial, insecticidal, anticancer and antiproliferative activities. It showed a MIC value of 31.25 μg ml against S. pneumoniae and LC50s values of 8.23, 9. 2 and 3 against third instar larvae of A. stephensi, A. aegypti and C. quinquefasciatust, respectively.(+)-δ-Cadinene (10, 50 and 100 μM) induced apoptosis and inhibited the growth of OVCAR-3 human ovarian cancer cells apoptosis and inhibited their proliferation.

(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM.

LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, and pancreatic.

KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.

CBP p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). It inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50: 2.71 μM). CBP p300-IN-15 can be used to study ovarian cancer.

VEGFR-IN-3 (compound 3f), a VEGFR inhibitor, exhibits potent anticancer activity by inhibiting the growth of OVCAR-4 and MDA-MB-468 cancer cells with IC50 values of 0.29 and 0.35 μM, respectively. It has potential applications in cancer research [1].

SZ-015268 is a CDK7 inhibitor (IC50: 23.56 nM) that inhibits the proliferation of HCC70 (IC50: 33 nM), OVCAR-3 (IC50: 80.56 nM), HCT116 (IC50: 12.53 nM), and HCC1806 (IC50: 61.55 nM) cells, exhibiting a highly significant anti-tumor effect.

E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor-targeting properties, demonstrating increased uptake in human ovarian cancer OVCAR-3 xenograft tumors, suggesting potential utility in cancer research [1].

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a palmitate derivative extracted from the root of Salvia miltiorrhiza, exhibits anti-cancer properties with DC50s of 25.5 μg mL against HeLa, 37.5 μg mL against HepG2, and 30.2 μg mL against OVCAR-3 human cancer cell lines [1].

Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

1-Decarboxy-3-oxo-ceanothic acid exhibits in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, mediated at least in part by induction of apoptosis. It is cytotoxic against OVCAR-3 and HeLa cancer cell lines with IC50 values of 2.8 and 6.6 microg mL, respectively, and has an IC50 of 11.3 microg mL against normal cell line FS-5.