neurokinin antagonist 1

Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine.

Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.

Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.

Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.

NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.

Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.

Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).

Tachykinin antagonist 1 is an antagonist of neurokinin receptors.

Casopitant mesylate (GW679769B) is a selective, brain-permeable, and orally active antagonist of the neurokinin 1 (NK1) receptor, and it is the second in its class of antiemetics.

Netupitant-D6 is the deuterium labeled Netupitant (T6905), which is a selective and orally active antagonist of neurokinin-1 receptor.

Vapreotide is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).

Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).

Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen

Tradipitant (VLY-686) is an antagonist of neurokinin-1.

Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.

Casopitant (GW679769) is an orally active neurokinin-1 (NK1) receptor antagonist, researched for its potential use in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

(1R,2S,3R)-Aprepitant (Compound ent-4) is a competitive antagonist of the human neurokinin-1 (NK-1) receptor. It holds potential for research in the treatment of nausea and vomiting related to cancer or postoperative conditions.

CP-99994 is a neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. It prevents colorectal sensitization under conditions of visceral hypersensitivity and reduces acetic acid-induced colorectal sensitization in a bladder-colon cross-sensitization model. CP-99994 also attenuates neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.

L 741671 is an antagonist of the neurokinin-1 receptor.

L 743310 is an antagonist of the neurokinin-1 receptor.

Lanepitant HCl trihydrate is an effective non-peptide neurokinin-1 receptor antagonist, suppresses neurogenic dural inflammation, and may have a role in migraine therapy.

S 16474 is an antagonist of Neurokinin-1 Receptor.

ZD6021 is an antagonist of neurokinin 1 receptor.

Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.