nad+

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).

NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.

Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux. Syrosingopine is an orally available antihypertensive drug with potential for cancer research in combination with metformin.

8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells.

6-alkyne NAD+ sodium (6-Parg NAD sodium) is a clickable signaling molecule and enzyme cofactor in NAD+ form. It is used in conjunction with fluorescence labeling for detecting poly(ADP-ribose) polymerase (PARP) protein substrates.

8-(2-azidobenzylthio) NAD+ is a derivatized version of NAD+, a signaling molecule and enzyme cofactor, featuring an azido group (azidobenzylthio) that enables click chemistry applications.

8-(4-Azidophenacylthio) NAD+ is a clickable variant of the essential signaling molecule and enzyme cofactor, NAD+.

2'-Deoxy-NAD+ sodium is the sodium salt form of 2'-Deoxy-NAD+. It acts as a non-competitive inhibitor of NAD+ with a Ki of 32 μM. Additionally, '2'-Deoxy-NAD+ sodium can be utilized as a substrate for studying ADP-ribosyltransferase reactions.

8-ET-NAD+ (sodium) is a derivative of NAD+ and is utilized for screening PARP1 gate mutations. It is also applicable in cancer research.

8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium)) is a derivative of NAD+, which functions as a signaling molecule and enzyme cofactor. This compound is utilized in screening gatekeeper mutations of PARP1 (poly[ADP-ribose] polymerase 1) that are sensitive to analogs.

8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for screening analog-sensitive gatekeeper mutations in poly (ADP-ribose) polymerase 1 (PARP1) and for synthesizing cyclic ADP-ribose (cADPR) derivatives.

8-Br-7-CH-NAD+ sodium is a derivative of NAD+ and can be used in the synthesis of TRPM2 antagonists.

Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM.

Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].

6-Biotin-17-NAD+ sodium (Biotin-LC-NAD+ sodium) is a biotinylated derivative of NAD+ and can be used to measure NADH dehydrogenase activity.

2'-Deoxy-NAD+ is a non-competitive inhibitor of NAD+ with an inhibitory constant (Ki) of 32 μM. It serves as a substrate for studying ADP-ribosyl transfer reactions.

NAD+-13C5 ammonium is the 13C-labeled form of NAD+ with ammonium.

NAD+ (Standard) is a reference standard for research and analysis in studies involving NAD+. NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme that transmits hydrogen ions and is involved in redox reactions in cells. NAD+ is involved in glycolysis, the citric acid cycle, fatty acid oxidation, etc. NAD+ accepts electrons from other molecules to form NADH, which then acts as a reducing agent to give electrons.

6-Alkyne-NAD+ sodium is an analogue of nicotinamide adenine dinucleotide (NAD). By conjugating with fluorescent tags, it serves as a fluorescent probe for labeling substrate proteins of poly(ADP-ribose) polymerase.

Fluorescein-NAD+ sodium serves as an alternative to radiolabeled NAD and acts as a substrate for ADP-ribosylation. It is applicable in PARP assays and has an extinction coefficient of 262 nm.