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  • Apoptosis
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mpnst

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  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
  • Natural Products
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    TargetMol | Natural_Products
JHU395
T117172079938-92-2In house
JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON). It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.
  • $61
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Flaccidoside II
T79983140694-19-5
Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) cell lines and ameliorates collagen-induced arthritis in mice [1] [2].
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SW106065
Gliocidin, SW-106065
T876262289-81-0
SW106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research
  • $31
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