mpep

MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).

5-MPEP is a neutral allosteric site ligand of the metabotropic glutamate receptor subtype 5 (mGlu5), blocking the effects of both the allosteric antagonist MPEP and potentiator CDPPB.

Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent.

M-5MPEP is a mGlu5 antagonist.

MMPEP is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM and a mGlu4 receptor positive allosteric modulator.

VPM peptide functions as a protease-cleavable dithiol cross-linker. It is capable of integration into the PEG-diacrylate (PEG-DA) macromer backbone, resulting in the formation of PEG hydrogel.

14:0 PEG2000 PE (DMPE-PEG2000) is a polyethylene glycol (PEG)-phospholipid conjugate that prevents vesicle aggregation during vesicle formulation and is useful in the preparation of nanostructured lipid carriers.

DMPE-PEG550 is a PEG lipid with functional end groups designed for the synthesis of liposomes (LPs) and the creation of conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) feature biotin modifications and carboxyl ends, allowing further coupling with other biomolecules. These functional nanoparticles are employed for targeted labeling of specific cell proteins. Using streptavidin as a linker, the biotinylated PEG lipid conjugate polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling applications in fluorescence-based imaging and sensing.

DMPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) with biotin modification and carboxyl termini can couple with other biomolecules. These functional nanoparticles are useful for targeted labeling of specific cell proteins. Utilizing streptavidin as a linker, biotinylated PEG lipid conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling practical applications in fluorescence-based imaging and sensing.

DMPE-PEG1000 is a PEG lipid functional end group used for liposome (LPs) synthesis, instrumental in designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) can undergo further coupling with other biomolecules via biotin modification and carboxyl terminals. These functionalized nanoparticles are applicable for targeted labeling of specific cell proteins. Using streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling utility in fluorescence-based imaging and sensing.

DMPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Liposomal nanoparticles (LNPs), with biotin modification and a carboxyl terminus, can further couple with other biomolecules. Functionalized nanoparticles target specific cell proteins for labeling. Utilizing streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, offering practicality in fluorescence-based imaging and sensing.

DMPE-PEG-amine (TFA) (MW 2000) is a phospholipid noted for its excellent biocompatibility and significant amphiphilic properties, making it a suitable and key excipient or formulation in drug delivery systems to achieve enhanced therapeutic outcomes. Additionally, DMPE-PEG-amine (TFA) (MW 2000) is applicable in drug delivery research.

DMPE-PEG2000 (14:0 PEG2000 PE) is a surface-functionalized material that enhances the stability of lipid nanocarriers and improves delivery efficiency to the eyes compared to PEG2000. This compound is particularly suitable for formulating ophthalmic preparations that require sterilization. In Ciprofloxacin nanostructured lipid carriers (NLCs), DMPE-PEG2000 significantly enhances transcorneal drug penetration and distribution within ocular tissues.

VPM peptide TFA is a peptide crosslinker that can be cleaved by dithiol proteases. It can be incorporated into the main chain of PEG-diacrylate (PEG-DA) macromonomers to form PEG hydrogels.

DMPE-PEG350 is a PEG lipid functional end group used for synthesizing liposomes (LPs) and designing conjugated polymer nanoparticles. These liposomal nanoparticles (LNPs), featuring biotin modification and a carboxyl end, can further couple with other biomolecules. Functionalized nanoparticles are applicable in the targeted labeling of specific cell proteins. Using streptavidin as a linker, the biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, facilitating fluorescence-based imaging and sensing applications.

DMPE-PEG3000 serves as a PEG lipid functional end group for synthesizing liposomes (LPs), designed for the engineering of conjugated polymer nanoparticles. Liposomal nanoparticles (LNPs) modified with biotin and carboxyl ends can further couple with other biomolecules. These functionalized nanoparticles facilitate the targeted labeling of specific cellular proteins. Using streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, enabling applications in fluorescence-based imaging and sensing.

ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.

VU0092273 is a positive allosteric modulator of mGlu5 that binds to the MPEP site, with an EC50 value of 0.27 μM.

VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.