mouth

Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.

Hexetidine (NSC-17764) is a bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.

Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

Antipyrine (Phenazone), an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs on drug-metabolizing enzymes in the liver.

Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.

Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Dequalinium chloride (Decabis) , a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.

UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC50 values of 15 nM and 19 nM, respectively. It is effective in inhibiting invasion and migration of TNBC cells in vitro. Additionally, UNC0638 hydrate acts as an inhibitor of EHMT1/2 and induces the expression of fetal hemoglobin (HbF) in cultures of human erythroid progenitor cells. Furthermore, it exhibits antiviral activity against FMDV (foot-and-mouth disease virus) and VSV (vesicular stomatitis virus), demonstrating remarkable potency and selectivity across various epigenetic and non-epigenetic targets.

Polynoxylin is an antiseptic. It is used for local treatment of the skin and the mouth.

Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.

Jun15716 is an inhibitor of the enterovirus 2C protein (EVs 2C) with Ki values of 15.9 μM for EV-D68, 44.2 μM for EV-A71, and 17.8 μM for CVB3. It exhibits potent antiviral activity against EV-D68 US/MO/14-18947 and CVB3 Nancy cells, with EC50 values of 1.0 μM and 0.7 μM, respectively. Jun15716 is applicable in viral infection research, including studies on meningitis, hand-foot-and-mouth disease (HFMD), and viral myocarditis.

Jun15799 is an inhibitor of the enterovirus 2C protein (EVs 2C), with Ki values of 0.8 μM, 21.1 μM, and 3.0 μM for EV-D68, EV-A71, and CVB3, respectively. It exhibits potent antiviral activity against EV-D68 US/MO/14-18947, EV-A71 Tainan/4643/1998, and CVB3 Nancy cells, with EC50 values of 0.3 μM, 11.4 μM, and 0.3 μM, respectively. Jun15799 is applicable in research related to viral infections such as meningitis, hand, foot, and mouth disease (HFMD), and viral myocarditis.

Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy.

Quinethazone is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

Procaine penicillin G (Duphapen) (procaine benzylpenicillin) is an antibiotic useful for the treatment of a number of bacterial infections. Specifically, it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites.

Hexylcaine HCl also called cyclaine or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.

Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses.

Tibezonium iodide, an oropharyngeal disinfectant, possesses antibacterial properties that aid in preventing mouth infections [1].

A20FMDV2, a peptide derived from the α-helical RGD cell-interacting domain of the VP1 capsid protein of foot-and-mouth disease virus (FMDV) serotype O, targets and binds αVβ6 integrin. It effectively disrupts αVβ6 integrin-mediated cell adhesion in H357 tongue squamous cell carcinoma cells that exhibit human αVβ6, with an inhibitory concentration (IC50) of 1.2 µM. Additionally, when labeled with 111indium-DTPA, A20FMDV2 (20 MBq) specifically attaches to αVβ6 integrin in a breast cancer mouse xenograft model using MCF10CA1a cells, facilitating targeted radiation imaging analysis.

NPI52 (Compound E1) is an inhibitor of foot-and-mouth disease virus 3C protease (FMDV 3Cpro), with IC50 values of 0.05 µM in FRET assays and 0.11 µM in cell-based assays [1].

ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that blocks EV71/CVA16 replication and virus-induced pyroptosis linked to viral pathogenesis. It effectively prevents EV71 infection in neonatal and young mice in animal models and can be used to study viral infections such as hand, foot, and mouth disease (HFMD) [1].

Antipyrine-d3 is a deuterated compound of Antipyrine. Antipyrine has a CAS number of 60-80-0. Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs on drug-metabolizing enzymes in the liver.