Search Result

Search Results for " mitochondria "

Targets

154

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
T72291	Mitochondria degrader-1
	Mitochondria Degrader-1 (example 5) is a potent agent for inducing the autophagic degradation of damaged mitochondria. It is applicable in the research of various conditions including neurodegenerative, cancer, inflammat...
T81631	NV-354	Mitochondria modulator-1
	Mitochondria Modulator-1, a mitochondrial regulator, enhances ATP production in mitochondria. It exhibits good oral bioavailability and blood-brain barrier permeability, along with robust plasma stability, showing promis...
T9423	Alkyne tyramide		Others
	Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe which enable biotin-independent detection of labeled proteins.		Others
T40130	Nur77 modulator 1	Nur77 modulator 1	Others
	Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell ...		Others
T3268	Mildronate	Kvaterin,Meldonium,Quaterin	Hydroxylase
	Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.		Hydroxylase
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T9211	Mito-LND	Mito-Loidamine	OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T6451	Clodronic acid disodium salt	Loron,Clodronate Disodium,Lodronate	Others
	Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.		Others
T0866	Propafenone	Rythmol,Propafenonum	Potassium Channel , MRP , Sodium Channel
	Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....		Potassium Channel , MRP , Sodium Channel
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T4620	Siramesine	Lu 28-179	Sigma receptor
	Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram...		Sigma receptor
T9232	Mitochondrial fusion promoter M1		Mitochondrial Metabolism
	Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia...		Mitochondrial Metabolism
T37657	Mitochondrial respiration-IN-1 hydrobromide
	Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1].
T72138	Mitochondrial respiration-IN-2
	Mitochondrial respiration-IN-2, a fluorine derivative of Virginiamycin M1, inhibits the mitochondrial translation of glioblastoma stem cells [1].
T72137	Mitochondrial respiration-IN-3
	Mitochondrial respiration-IN-3, a fluorine derivative of Dalfopristin, possesses cell membrane permeability and exhibits the capability to inhibit mitochondrial translation in glioblastoma stem cells. This compound is ut...
T19072	TMRE	Tetramethylrhodamine ethyl ester perchlorate	Others
	TMRE (Tetramethylrhodamine ethyl ester perchlorate) is a mitochondria specific dye (λex: 550 nm, λem: 575 nm).		Others
T4168	Visomitin	SKQ1	Reactive Oxygen Species
	Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).		Reactive Oxygen Species
T77553	MHI-148	IR-808
	MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not ...
T77344	IcFSP1		Apoptosis
	icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.		Apoptosis
T19428	Mito-TEMPO		Reactive Oxygen Species , Mitochondrial Metabolism
	Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO scavenges superoxide and alkyl radicals and prevents mitochondrial oxidation, necrosis and apoptosis.		Reactive Oxygen Species , Mitochondrial Metabolism
T4441	UK-5099	UK 5099,PF-1005023,UK5099	Others , Mitochondrial Metabolism
	UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM) [1].		Others , Mitochondrial Metabolism
T8366	Mitochonic acid 5	MA-5	Mitochondrial Metabolism
	Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of f...		Mitochondrial Metabolism
T5114	Pyridaben		Calcium Channel , Parasite
	Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).		Calcium Channel , Parasite
T14941	CGP37157	7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one	Na+/Ca2+ Exchanger
	CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.		Na+/Ca2+ Exchanger
T9558	KL-11743		transporter
	KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.		transporter
T9807	CPDS		Others
	CPDS is a non permeant thiol agent which affects several mitochondrial functions. In rat liver mitochondria, CPDS inhibits only the Pi/OH- carrier; both CPDS and n-butylmalonate are necessary to inhibit completely Pi ent...		Others
T33412	MitoPQ	MitoParaquat	Glucokinase , transporter
	MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of...		Glucokinase , transporter
T75342	MitoSOX Red		Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superoxide upon entry into the mitochondria and is not oxidized by...
T7460	α-Cyano-4-hydroxycinnamic acid	α-Cyano-4-hydroxycinnamic acid(α-CHCA)	Monocarboxylate transporter
	α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).		Monocarboxylate transporter
TP1095	Elamipretide	MTP-131,RX-31,SS-31	Others
	Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier ...		Others
T37563	C22 Ceramide (d18:1/22:0)	Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)
	C22 Ceramide (d18:1/22:0) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isola...
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T28047	Mitoquinone-cyclodextrin	MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin
	Mitoquinone-cyclodextrin is a 1:1 molar ratio complex of Mitoquinone mesylate with cyclodextrin. Mitoquinone mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to ...
T34892	TM608	TM-608,TM 608
	TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-re...
T22370	Mitoquinol mesylate		Others
	Mitoquinol, a ubiquinone derivative, specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. Mitoquinol is an antioxidant, protecting mitochondria from oxidative damage...		Others
T70270	SMTIN-P01
	SMTIN-P01 is a mitochondria-targeted Hsp90 inhibitor. It is made from the isopropyl amine of the Hsp90 inhibitor PU-H71 being replaced with the mitochondria-targeting moiety triphenylphosphonium.
T12048	Mito-apocynin (C2)		Others
	Mito-apocynin (C2) is an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, has antineuroinflammatory effects.		Others
T35965	MitoTEMPOL
	MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-h...
T33404	MitoBADY	Mito-BADY,Mito BADY
	Mitobady is a sensitive and specific Raman probe, which can be used for living cell imaging of mitochondria.
T31882	FTY720-Mitoxy	FTY 720 Mitoxy,FTY-720-Mitoxy
	FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria.
T26242	SW IV-52	SW-IV-52,SW IV52,SW IV 52,SWIV52
	SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.
T71866	Cochlioquinone B
	Cochlioquinone B is a phytotoxin that inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from heart mitochondria.
T35962	MitoPBN
	MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial m...
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an ...
T39433	HKOCl-4m
	HKOCl-4m is a rhodol-based fluorescent probe designed for the specific and deliberate targeting of mitochondria, enabling the monitoring of mitochondrial hypochlorous acid (HOCl).
T11356	Gamitrinib TPP hexafluorophosphate		HSP
	Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functions by inhibiting the mitochondrial matrix, making it an eff...		HSP
T23587	8-CSC	8 CSC,CSC
	8-CSC is a dual agent endowed with good hMAO-B inhibitory activity (Ki: 235 nM in baboon liver mitochondria) and A2A affinity (Ki: 36 nM in rat brain striatal membranes receptor).

Compounds

COH-SR4

T8740

Synonym: COH-SR4 (Mitochondria uncoupler SR4)

Target: Others, AMPK

Mitochondria degrader-1

Synonym: Mitochondria modulator-1

Synonym: Nur77 modulator 1

Target: Others

Mildronate

T3268

Synonym: Kvaterin,Meldonium,Quaterin

Target: Apoptosis, Others, Mitochondrial Metabolism

Mito-LND

T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Siramesine hydrochloride

T1885

Synonym: Lu 28-179 hydrochloride

Target: Ferroptosis, Sigma receptor, lysosomal autophagy

Clodronic acid disodium salt

T6451

Synonym: Loron,Clodronate Disodium,Lodronate

Target: Others

Propafenone

T0866

Synonym: Rythmol,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

MG-101

T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101

Target: Cysteine Protease, Proteasome

Siramesine

T4620

Synonym: Lu 28-179

Target: Sigma receptor

Mitochondrial fusion promoter M1

T9232

Synonym:

Target: Mitochondrial Metabolism

Mitochondrial respiration-IN-1 hydrobromide

T37657

Synonym:

Target:

Mitochondrial respiration-IN-2

T72138

Synonym:

Target:

Mitochondrial respiration-IN-3

Synonym: Tetramethylrhodamine ethyl ester perchlorate

Target: Reactive Oxygen Species

Target: Reactive Oxygen Species, Mitochondrial Metabolism

UK-5099

T4441

Synonym: UK 5099,PF-1005023,UK5099

Target: Others, Mitochondrial Metabolism

Mitochonic acid 5

T8366

Synonym: MA-5

Target: Mitochondrial Metabolism

Pyridaben

T5114

Synonym:

Target: Calcium Channel, Parasite

CGP37157

T14941

Synonym: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one

Target: Na+/Ca2+ Exchanger

Synonym: MitoParaquat

Target: Glucokinase, transporter

MitoSOX Red

T75342

Synonym:

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

α-Cyano-4-hydroxycinnamic acid

T7460

Synonym: α-Cyano-4-hydroxycinnamic acid(α-CHCA)

Target: Monocarboxylate transporter

Elamipretide

TP1095

Synonym: MTP-131,RX-31,SS-31

Target: Others

C22 Ceramide (d18:1/22:0)

T37563

Synonym: Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)

Target:

SKF-96365 hydrochloride

T2170

Synonym: SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

Mitoquinone-cyclodextrin

T28047

Synonym: MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin

Target:

TM608

T34892

Synonym: TM-608,TM 608

Synonym: Mito-BADY,Mito BADY

Target:

FTY720-Mitoxy

T31882

Synonym: FTY 720 Mitoxy,FTY-720-Mitoxy

Target:

SW IV-52

T26242

Synonym: SW-IV-52,SW IV52,SW IV 52,SWIV52

Gamitrinib TPP hexafluorophosphate

Cat No.	Product Name	Synonyms	Targets
T7922	Kresoxim-Methyl		Others , Mitochondrial Metabolism , Antifungal
	Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .		Others , Mitochondrial Metabolism , Antifungal
T0846	L-Carnitine	L(-)-Carnitine,Levocarnitine	Endogenous Metabolite , Fatty Acid Synthase
	L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utiliz...		Endogenous Metabolite , Fatty Acid Synthase
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T10148	4-Hydroxynonenal	4-HNE	Dehydrogenase , Endogenous Metabolite
	4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).		Dehydrogenase , Endogenous Metabolite
T2203	D-Carnitine hydrochloride	(S)-Carnitine Hydrochloride,L-Carnitine hydrochloride	Others , Endogenous Metabolite
	D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) is a constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemi...		Others , Endogenous Metabolite
TL0006	Cichoric Acid	Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species , HIV Protease
	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and ...		Reactive Oxygen Species , HIV Protease
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
TN6714	Geranylgeraniol	FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095	Apoptosis
	Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ...		Apoptosis
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
TN3594	Cardanol (C15:1)		Apoptosis , Others
	Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.		Apoptosis , Others
T33817	Orellanine	2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one	Others
	Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat l...		Others
T1068	Dithranol	1,8,9-trihydroxyanthracene,cignoline,Anthralin	Others , DNA/RNA Synthesis
	Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.		Others , DNA/RNA Synthesis
T27012	Chrysotoxine	Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol	NF-κB
	Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.		NF-κB
TN1274	4-Allylcatechol	4-Allylpyrocatechol,Hydroxychavicol	Others
	4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical ...		Others
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK
T6323	Oligomycin A	MCH 32	ATPase , Antibiotic , Antifungal
	Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.		ATPase , Antibiotic , Antifungal
T2731	Usnic Acid	Usniacin	Antibacterial , Autophagy
	Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells.		Antibacterial , Autophagy
T5055	For-Met-OH	fMet,N-Formyl-L-methionine	Others , Endogenous Metabolite
	For-Met-OH (N-Formyl-L-methionine) is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formyl methionyl tRNA. This process occurs in Escherichia coli and other ...		Others , Endogenous Metabolite
T5S0285	Cistanoside A		Others
	1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat...		Others
T5715	(E)-Flavokawain A	FLAVOKAVAIN A(P)	Apoptosis , P450
	(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.		Apoptosis , P450
T2970	Rotenone	Rotenon,Paraderil,Barbasco,Rotocide,Dactinol	Apoptosis , Dehydrogenase , Mitochondrial Metabolism , p53 , Autophagy
	Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces...
T7050	Alpha-Tocopherolquinone	Metarene	Antioxidant
	During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also disp...		Antioxidant
T4S1335	Daphnoretin	Dephnoretin,Thymelol	Influenza Virus , Caspase , PKC
	1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ...		Influenza Virus , Caspase , PKC
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T10662L	Calcimycin	Antibiotic A-23187,A-23187	Apoptosis , Antibacterial , Antibiotic , Autophagy , Antifungal
	Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylatio...
T3921	Punicalagin		SARS-CoV , HBV
	Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumula...		SARS-CoV , HBV
T3926	Echinatin	Retrochalcone	Free radical scavengers
	Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...		Free radical scavengers
T4838	(S)-Malic acid	L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid	Others , Endogenous Metabolite
	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic a...		Others , Endogenous Metabolite
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T4809	Pyrimidine	Metadiazine	Others , Endogenous Metabolite
	Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ...		Others , Endogenous Metabolite
T4900	(±)-Methyl Jasmonate	(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others , Endogenous Metabolite
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester)induces the synthesis of proteinase inhibitors in plant leaves. In cancer cells, it suppresses proliferation and induces apoptosis. Mo...		Others , Endogenous Metabolite
T5287	N-Acetyl-L-aspartic acid	AC-ASP-OH,N-Acetylaspartic acid	Others , Endogenous Metabolite
	N-Acetyl-L-aspartic acid (AC-ASP-OH) is a derivative of aspartic acid. It is the second most concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartate a...		Others , Endogenous Metabolite
T4837	Itaconic acid	methylene-butanedioicaci	Others , Endogenous Metabolite
	Itaconic acid (methylene-butanedioicaci), also known as itaconate, belongs to the class of organic compounds known as branched fatty acids. These are fatty acids containing a branched chain. Itaconic acid exists as a sol...		Others , Endogenous Metabolite
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T4880	L-Dihydroorotic acid		Others , Endogenous Metabolite
	L-Dihydroorotic acid, also known as (S)-4,5-dihydroorotate or dihydro-L-orotate, belongs to the class of organic compounds known as alpha amino acids and derivatives. Within the cell, L-dihydroorotic acid is primarily lo...		Others , Endogenous Metabolite
T38054	Avenaciolide
	Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM).
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an AD...
TN1572	Desacetylcinobufotalin		Others
	Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.		Others
TN2039	Panaxydol		cAMP , p38 MAPK , JNK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...		cAMP , p38 MAPK , JNK
TN2191	Scutebarbatine A		BCL , Caspase
	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and...		BCL , Caspase
T83281	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine
	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine, an alkaloid, markedly alters the characteristics of cellular organelles—specifically, early endosomes, mitochondria, and autophagosomes—in Parkinson’s Disease patient-derived ...
TN5201	Uncarinic acid E		BCL , MEK , Caspase , PI3K , Antifection , p53
	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu...		BCL , MEK , Caspase , PI3K , Antifection , p53
T20123	L-Carnitine hydrochloride	L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80
	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It...
T75630	Ganoderic acid Mf
	Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests th...
T75629	Ganoderic acid Mk
	Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making ...
T4415	Katacine		Others
	Katacine inhibits of oxygen consumption and suppresses the speed of electrons transfer from oxidation substrates via respiratory chain of mitochondria to molecular oxygen.Katacine is a mixture of polymers of A-type proan...		Others
TMA1008	Ganoderic acid S		Others
	A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the t...		Others
TN6394	Alisol B acetate
	Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to t...
T79971	Asparanin A		Apoptosis
	Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It effectively inhibits cancer cell proliferation and has show...		Apoptosis
TN3525	Boehmenan		ERK , Phosphatase , EGFR , PARP , MEK , Wnt/beta-catenin , Akt , Caspase , STAT , p53
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotox...
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Natural Products

Kresoxim-Methyl

T7922

Synonym:

Target: Others, Mitochondrial Metabolism, Antifungal

L-Carnitine

T0846

Synonym: L(-)-Carnitine,Levocarnitine

Target: Endogenous Metabolite, Fatty Acid Synthase

Urolithin C

TN7108

Synonym:

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

4-Hydroxynonenal

T10148

Synonym: 4-HNE

Target: Dehydrogenase, Endogenous Metabolite

D-Carnitine hydrochloride

T2203

Synonym: (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cichoric Acid

TL0006

Synonym: Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Sodium dichloroacetate

T3604

Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

Geranylgeraniol

TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095

Target: Apoptosis

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Cardanol (C15:1)

TN3594

Synonym:

Target: Apoptosis, Others

Orellanine

T33817

Synonym: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one

Target: Others

Dithranol

T1068

Synonym: 1,8,9-trihydroxyanthracene,cignoline,Anthralin

Target: Others, DNA/RNA Synthesis

Chrysotoxine

T27012

Synonym: Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol

Target: NF-κB

4-Allylcatechol

TN1274

Synonym: 4-Allylpyrocatechol,Hydroxychavicol

Target: P450, NOS, NF-κB, HIF, AMPK

Oligomycin A

T6323

Synonym: MCH 32

Target: ATPase, Antibiotic, Antifungal

Usnic Acid

T2731

Synonym: Usniacin

Target: Antibacterial, Autophagy

For-Met-OH

T5055

Synonym: fMet,N-Formyl-L-methionine

Target: Others, Endogenous Metabolite

Synonym: FLAVOKAVAIN A(P)

Target: Apoptosis, P450

Rotenone

T2970

Synonym: Rotenon,Paraderil,Barbasco,Rotocide,Dactinol

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy

alpha-Tocopherolquinone

Synonym: Dephnoretin,Thymelol

Target: Influenza Virus, Caspase, PKC

Marein

TN1911

Synonym:

Target: transporter, Akt, HDAC, AMPK

Calcimycin

T10662L

Synonym: Antibiotic A-23187,A-23187

Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal

Punicalagin

T3921

Synonym:

Target: SARS-CoV, HBV

Echinatin

T3926

Synonym: Retrochalcone

Target: Free radical scavengers

(S)-Malic acid

T4838

Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid

Target: Others, Endogenous Metabolite

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

Pyrimidine

T4809

Synonym: Metadiazine

Target: Others, Endogenous Metabolite

(±)-Methyl Jasmonate

T4900

Synonym: (±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

N-Acetyl-L-aspartic acid

T5287

Synonym: AC-ASP-OH,N-Acetylaspartic acid

Target: Others, Endogenous Metabolite

Itaconic acid

T4837

Synonym: methylene-butanedioicaci

Target: Others, Endogenous Metabolite

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

L-Dihydroorotic acid

T4880

Synonym:

Target: Others, Endogenous Metabolite

Desacetylcinobufotalin

Target: cAMP, p38 MAPK, JNK

6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine

Target: BCL, MEK, Caspase, PI3K, Antifection, p53

L-Carnitine hydrochloride

T20123

Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00265	Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)	Bovine	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX.
TMPH-00220	Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th...
TMPY-00541	LON PROTEASE Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura...
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-02431	BCL-XL Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPH-01691	TOMM40 Protein, Human, Recombinant (GST)	Human	E. coli
	Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with ...
TMPH-02333	SLC25A19 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
TMPY-02311	AGO3 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Argonaute (Ago) protein family plays a key role in the RNA interference (RNAi) process in different insects including Lepidopteran. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermo...
TMPJ-00956	MDH2 Protein, Human, Recombinant (His)	Human	Human Cells
	Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofac...
TMPY-03288	USP30 Protein, Human, Recombinant (SUMO)	Human	Baculovirus-Insect Cells
	Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnec...
TMPY-03993	KIAA1279 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The ...
TMPY-00589	KIAA1279 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The ...
TMPH-01002	BCAP31 Protein, Human, Recombinant (GST)	Human	E. coli
	Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeti...
TMPH-00021	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His)	Acinetobacter baumannii	Yeast
	Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as...
TMPH-01561	ISCU Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic Functions as a cytoplasmic scaffold protein for the de...
TMPH-02971	Vimentin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-00022	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO)	Acinetobacter baumannii	E. coli
	Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as...
TMPJ-00718	AIF Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is t...
TMPH-03281	PRKN Protein, Rat, Recombinant (His & Myc)	Rat	Baculovirus
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02970	Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-00535	Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)	EBV	E. coli
	Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro...
TMPH-01262	PRKN Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPK-01051	BLOC1S2 Protein, Human, Recombinant	Human	E. coli
	BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of t...
TMPH-00023	Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc)	Acinetobacter baumannii	E. coli
	Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of ...
TMPH-01287	TUFM Protein, Human, Recombinant (His)	Human	E. coli
	Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochon...
TMPJ-00955	MDH1 Protein, Human, Recombinant (His)	Human	E. coli
	Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate...
TMPY-01140	ACOT13/THEM2 Protein, Human, Recombinant (His)	Human	E. coli
	The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty ...
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto...
TMPY-03572	PTRH2 Protein, Human, Recombinant (His)	Human	E. coli
	PTH2, also known as PTRH2, is a mitochondrial protein that belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs whic...
TMPH-01898	PARL Protein, Human, Recombinant (Myc)	Human	in vitro E. coli expression system
	Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apopt...
TMPY-02044	SOD2 Protein, Human, Recombinant	Human	E. coli
	Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is locat...
TMPY-02686	PON3 Protein, Human, Recombinant (S50N, His)	Human	Baculovirus-Insect Cells
	PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expressi...
TMPY-03412	GGCT Protein, Human, Recombinant (His)	Human	E. coli
	GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in ...
TMPY-00924	SMAC Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
TMPH-01802	NME4 Protein, Human, Recombinant (GST)	Human	E. coli
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through...
TMPH-01664	OMA1 Protein, Human, Recombinant (His & SUMO)	Human	in vitro E. coli expression system
	Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA...
TMPH-02520	BCL2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-03245	BCL2 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPY-03464	ECH1 Protein, Human, Recombinant (His)	Human	E. coli
	ECH1 is a member of the hydratase/isomerase superfamily. ECH1 shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. ECH1 con...
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His)	Human	Human Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox...
TMPY-04477	CKMT1A Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes that encodes the ubiquitous mitoch...
TMPH-01688	UCP1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and...
TMPJ-01087	TIM14 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner memb...
TMPY-03658	ETHE1 Protein, Human, Recombinant (His)	Human	E. coli
	ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytopl...
TMPH-01687	UCP1 Protein, Human, Recombinant (His)	Human	Yeast
	Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and...
TMPY-03755	Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)	Human	E. coli
	GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encode...
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Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)

TMPH-00265

Species: Bovine

Expression System: E. coli

Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)

TMPH-00220

Species: Bovine

Expression System: E. coli

LON PROTEASE Protein, E. coli, Recombinant (His)

TMPY-00541

Species: E. coli

Expression System: E. coli

Alpha-Synuclein Protein, Human, Recombinant

TMPY-02512

Species: Human

Expression System: E. coli

BCL2 Protein, Human, Recombinant (His)

TMPY-02700

Species: Human

Expression System: E. coli

BCL-XL Protein, Human, Recombinant (His)

TMPY-02431

Species: Human

Expression System: E. coli

TOMM40 Protein, Human, Recombinant (GST)

TMPH-01691

Species: Human

Expression System: E. coli

SLC25A19 Protein, Human, Recombinant (His)

TMPH-02333

Species: Human

Expression System: in vitro E. coli expression system

AGO3 Protein, Human, Recombinant (His)

TMPY-02311

Species: Human

Expression System: Baculovirus-Insect Cells

MDH2 Protein, Human, Recombinant (His)

TMPJ-00956

Species: Human

Expression System: Human Cells

USP30 Protein, Human, Recombinant (SUMO)

TMPY-03288

Species: Human

Expression System: Baculovirus-Insect Cells

KIAA1279 Protein, Human, Recombinant (His & GST)

TMPY-03993

Species: Human

Expression System: Baculovirus-Insect Cells

KIAA1279 Protein, Human, Recombinant

TMPY-00589

Species: Human

Expression System: Baculovirus-Insect Cells

BCAP31 Protein, Human, Recombinant (GST)

TMPH-01002

Species: Human

Expression System: E. coli

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His)

TMPH-00021

Species: Acinetobacter baumannii

Expression System: Yeast

ISCU Protein, Human, Recombinant (His & Myc)

TMPH-01561

Species: Human

Expression System: Baculovirus

Vimentin Protein, Mouse, Recombinant (His & Myc)

TMPH-02971

Species: Mouse

Expression System: HEK293

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO)

TMPH-00022

Species: Acinetobacter baumannii

Expression System: E. coli

AIF Protein, Human, Recombinant (His)

TMPJ-00718

Species: Human

Expression System: E. coli

PRKN Protein, Rat, Recombinant (His & Myc)

TMPH-03281

Species: Rat

Expression System: Baculovirus

Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc)

TMPH-02970

Species: Mouse

Expression System: E. coli

PRKN Protein, Mouse, Recombinant (GST)

TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

TMPH-01263

Species: Human

Expression System: E. coli

Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)

TMPH-00535

Species: EBV

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & Myc)

TMPH-01262

Species: Human

Expression System: Baculovirus

BNIP3L Protein, Human, Recombinant

TMPY-02376

Species: Human

Expression System: E. coli

BLOC1S2 Protein, Human, Recombinant

TMPK-01051

Species: Human

Expression System: E. coli

Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc)

TMPH-00023

Species: Acinetobacter baumannii

Expression System: E. coli

TUFM Protein, Human, Recombinant (His)

TMPH-01287

Species: Human

Expression System: E. coli

MDH1 Protein, Human, Recombinant (His)

TMPJ-00955

Species: Human

Expression System: E. coli

ACOT13/THEM2 Protein, Human, Recombinant (His)

TMPY-01140

Species: Human

Expression System: E. coli

FKBP4 Protein, Human, Recombinant (His)

TMPJ-01076

Species: Human

Expression System: E. coli

PTRH2 Protein, Human, Recombinant (His)

TMPY-03572

Species: Human

Expression System: E. coli

PARL Protein, Human, Recombinant (Myc)

TMPH-01898

Species: Human

Expression System: in vitro E. coli expression system

SOD2 Protein, Human, Recombinant

TMPY-02044

Species: Human

Expression System: E. coli

PON3 Protein, Human, Recombinant (S50N, His)

TMPY-02686

Species: Human

Expression System: Baculovirus-Insect Cells

GGCT Protein, Human, Recombinant (His)

TMPY-03412

Species: Human

Expression System: E. coli

SMAC Protein, Human, Recombinant (His)

TMPY-00924

Species: Human

Expression System: E. coli

NME4 Protein, Human, Recombinant (GST)

TMPH-01802

Species: Human

Expression System: E. coli

OMA1 Protein, Human, Recombinant (His & SUMO)

TMPH-01664

Species: Human

Expression System: in vitro E. coli expression system

BCL2 Protein, Mouse, Recombinant (His)

TMPH-02520

Species: Mouse

Expression System: E. coli

BCL2 Protein, Rat, Recombinant (His)

TMPH-03245

Species: Rat

Expression System: in vitro E. coli expression system

ECH1 Protein, Human, Recombinant (His)

TMPY-03464

Species: Human

Expression System: E. coli

PRDX5 Protein, Human, Recombinant (His)

TMPJ-00933

Species: Human

Expression System: Human Cells

CKMT1A Protein, Human, Recombinant (His)

TMPY-04477

Species: Human

Expression System: Baculovirus-Insect Cells

UCP1 Protein, Human, Recombinant (His & SUMO)

TMPH-01688

Species: Human

Expression System: E. coli

TIM14 Protein, S. cerevisiae, Recombinant

TMPJ-01087

Species: S. cerevisiae

Expression System: E. coli

ETHE1 Protein, Human, Recombinant (His)

TMPY-03658

Species: Human

Expression System: E. coli

UCP1 Protein, Human, Recombinant (His)

TMPH-01687

Species: Human

Expression System: Yeast

Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)

TMPY-03755

Species: Human

Expression System: E. coli

--------- More ---------

Cat No.	Product Name
L5300	Mitochondria-Targeted Compound Library	830 compounds
	A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
L8700	Ferroptosis Compound Library	800 compounds
	A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L2520	Glycometabolism Compound Library	708 compounds
	708 glycometabolism-related comounds, can be used for HTS and HCT;
L9840	Anti-Alzheimer's Disease Compound Library	1040 compounds
	A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...

Libraries

Mitochondria-Targeted Compound Library

L5300

Compounds: 830

Ferroptosis Compound Library

L8700

Compounds: 800

Glycometabolism Compound Library

L2520

Compounds: 708

Anti-Alzheimer's Disease Compound Library

L9840

Compounds: 1040

Glutamine Metabolism Compound Library

L2550

Compounds: 580