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Cat No. | Product Name | Synonyms | Targets |
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T71584 | Microtubule Inhibitor 185322 | ||
Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells. | |||
T12034 | Microtubule inhibitor 1 | Others | |
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells). | |||
T62448 | Microtubule inhibitor 6 | ||
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r... | |||
T61749 | Microtubule inhibitor 2 | ||
Microtubule inhibitor 2 is a highly potent and selective microtubule inhibitor, which is orally active. It induces cell death via ferroptosis, and exhibits notable antitumor activity [1]. | |||
T61765 | Microtubule inhibitor 5 | ||
Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function. It exhibits a substantial cytotoxic effect on NCI-H460 cells, with an IC50 value of 154.5 nM. Moreover, this c... | |||
TP1420 | Microtubule-associated protein tau (26-44) | ||
Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine. | |||
T62642 | Microtubule inhibitor 4 | ||
Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity. | |||
T62867 | Microtubule inhibitor 3 | ||
Compounds 17o (IC50: 14.0 nM, NCI-H460) and 17p (IC50: 2.9 nM, NCI-H460) with furan moieties showed potent cytotoxic effects at the nanomolar level against various human cancer cell lines. | |||
T62639 | Microtubule inhibitor 7 | ||
Compounds 17o (IC50= 14.0 nM, NCI-H460) and 17p (IC50= 2.9 nM, NCI-H460) with furan moieties show potent nanomolar levels of cytotoxic activity against various human cancer cell lines. | |||
T74166 | Microtubule destabilizing agent-1 | ||
Microtubule destabilizing agent-1 (Compound 12b), a hydroxamic acid-based microtubule destabilizing agent (MDA), exhibits potent antitumor activity, favorable metabolic stability, and high bioavailability, making it a pr... | |||
T79508 | Microtubule stabilizing agent-1 | ||
Compound 3l, a paclitaxel derivative known as Microtubule Stabilizing Agent-1, effectively enhances tubulin polymerization and demonstrates antitumor efficacy [1]. | |||
T14349 | Auristatin F | Microtubule Associated | |
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates. | |||
T15236 | Entasobulin | Microtubule Associated | |
Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity. | |||
T60026 | KIF18A-IN-2 | Microtubule Associated | |
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities. | |||
T9504 | MAP4343 | Microtubule Associated | |
Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of n... | |||
T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T39994 | Sovilnesib | Microtubule Associated | |
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research. | |||
T14348 | Auristatin E | Microtubule Associated | |
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an... | |||
T21632 | Myoseverin | Others , Microtubule Associated | |
Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str... | |||
T7800 | TN-16 | Microtubule Associated | |
TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM) | |||
T8513 | Spastazoline | Others | |
Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ). | |||
T4077 | PE859 | Beta Amyloid , Gamma-secretase , Microtubule Associated | |
PE859 is a potent inhibitor of both tau and Aβ aggregation. | |||
T14694 | BNC105 | Microtubule Associated | |
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties. | |||
T5699 | SSE15206 | Apoptosis , Microtubule Associated | |
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. | |||
T8342 | BRD9876 | Others , Kinesin , Microtubule Associated | |
BRD9876 is a selective inhibitor of MM1S growth. | |||
T6393 | ARQ 621 | Kinesin | |
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. | |||
T2511 | Plinabulin | NPI-2358 | Microtubule Associated |
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the... | |||
T9974 | Antiproliferative agent-13 | Dehydrogenase | |
Antiproliferative agent-13 is a compound with antiproliferative activity. | |||
T6071 | Parbendazole | SKF 29044 | Microtubule Associated , Parasite |
Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations. | |||
T2090 | Lexibulin | CYT-997 | Apoptosis , Reactive Oxygen Species , Microtubule Associated |
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this... | |||
T41248 | Thiocolchicine | Microtubule Associated | |
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. | |||
T4232 | VCMMAE | mc-vc-PAB-MMAE | Microtubule Associated |
VCMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity. | |||
T4029 | BTB-1 | BTB 1,NSC156750 | Microtubule Associated |
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A. | |||
T15141 | DM4 | Ravtansine | Others , Microtubule Associated |
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. | |||
T4451 | Estramustine phosphate sodium | Ro 21-8837/001,Estramustine phosphate disodium | Apoptosis , Microtubule Associated |
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. | |||
T71582 | Niguldipine Free Base | ||
Niguldipine Free Base is a calcium channel blocker and a₁-adrenergic receptor antagonist and a clinical modulator of multidrug resistance. | |||
T14350 | Soblidotin | Auristatin PE,TZT-1027 | Microtubule Associated |
Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative. | |||
T1753 | D-64131 | Microtubule Associated | |
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. | |||
T6345 | Tirbanibulin | KX2-391,KX-01 | Microtubule Associated , Src |
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibit... | |||
T1758 | ABT-751 | E7010 | Microtubule Associated , Autophagy |
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. | |||
T9812 | Tubulin inhibitor 24 | Microtubule Associated | |
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. | |||
T50005 | Sertaconazole | Antifungal | |
Sertaconazole is a broad-spectrum antifungal. | |||
T3256 | MMAF | MonoMethyl auristatin F | Others , Microtubule Associated |
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin. | |||
T0838 | Triclabendazole | CGA89317 | Microtubule Associated , Parasite |
Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease. | |||
T0009 | Flubendazole | Flumoxanal,Flumoxane,NSC 313680,Fluvermal | Apoptosis , Microtubule Associated , Parasite |
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans. | |||
T15012 | Crolibulin | EPC2407 | Microtubule Associated |
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization. | |||
T2802 | Nocodazole | R17934,Oncodazole | Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9 |
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis. | |||
T2060 | ELR510444 | LR-510444,LR510444,LR 510444 | Apoptosis , Microtubule Associated |
ELR510444 (LR510444) is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpress... | |||
T6075 | Epothilone B | Patupilone,EPO 906 | Apoptosis , Microtubule Associated , Antibiotic , Antifungal |
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditi... | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36850 | Curvulin | Microtubule Associated | |
Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly. | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T8188 | Podophyllotoxone | Others , Microtubule Associated | |
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro. | |||
T21351 | Maytansine | NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine | Microtubule Associated , Antibiotic |
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. | |||
T1121 | Podofilox | Podophyllotoxin,(+)-Shikonin | Microtubule Associated , Topoisomerase |
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit... | |||
T3S0209 | Vincristine | ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR | |
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato... | |||
T2773 | Vindoline | Microtubule Associated | |
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. | |||
TN2256 | Taccalonolide B | Microtubule Associated | |
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM. | |||
TN1087 | Deoxypodophyllotoxin | Apoptosis , Microtubule Associated , Autophagy | |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. | |||
TN2254 | Taccalonolide A | Apoptosis , Microtubule Associated | |
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ... | |||
T6490 | Epothilone A | epothile,Epo A | Apoptosis , Microtubule Associated |
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM. | |||
T2217 | Cephalomannine | Baccatin III | Microtubule Associated |
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity. | |||
T0320 | Colchicine | Colcin,Colchineos,Colchisol | Apoptosis , Microtubule Associated , Autophagy |
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of... | |||
T0968 | Paclitaxel | Taxol,NSC 125973 | Apoptosis , Microtubule Associated , Autophagy |
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy. | |||
T16016 | Maytansinol | Ansamitocin P-0 | Apoptosis , Microtubule Associated |
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro. | |||
T1668 | Vinblastine sulfate | NSC49842,Vincaleukoblastine sulfate salt | Microtubule Associated , AChR , Autophagy |
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM). | |||
T3S2372 | 7-epi-Taxol | 7-Epitaxol,7-epi-Paclitaxel | Others , Microtubule Associated |
1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol. | |||
T1034 | Docetaxel | NSC 628503,RP-56976 | Apoptosis , Microtubule Associated , Endogenous Metabolite |
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,... | |||
T1270 | Vincristine sulfate | Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate | Apoptosis , Microtubule Associated |
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle. | |||
T19720 | Colcemid | C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine | Microtubule Associated |
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning. | |||
TP1180 | Dolastatin 10 | NSC 376128,DLS 10 | Microtubule Associated |
Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization. | |||
T6212 | Combretastatin A4 | CA4,CRC 87-09 | Microtubule Associated |
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). | |||
T22455 | Vindesine sulfate | DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule... | |||
T2220 | 2-Methoxyestradiol | NSC-659853,2-MeOE2,2-ME2 | Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy |
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli... | |||
T1152 | Albendazole | SKF-62979 | HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite |
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations. | |||
T0186 | Docetaxel trihydrate | RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate | Apoptosis , BCL , Microtubule Associated |
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i... | |||
T2937 | 4'-Demethylepipodophyllotoxin | 4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin | Microtubule Associated |
4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly. | |||
T5165 | 10-Deacetyltaxol | 10-DAT,10-Desacetyl Paclitaxel,Deacetyltaxol,10-deacetyl-paclitaxel,Deacetyl Paclitaxel | Others , Microtubule Associated |
10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks. | |||
T2543 | Cabazitaxel | XRP6258,RPR-116258A,TXD 258,taxoid XRP6258 | Microtubule Associated , Autophagy |
Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel. | |||
T6213 | Vinorelbine ditartrate | Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate | Microtubule Associated , Autophagy |
Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition. | |||
T6272 | Fosbretabulin Disodium | Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium | Apoptosis , Microtubule Associated |
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit... | |||
T5749 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside | Others , Microtubule Associated |
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. | |||
T22262 | Ansamitocin p-3 | Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222 | Microtubule Associated |
Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization. | |||
TQ0202 | Epothilone D | KOS 862 | Microtubule Associated |
Epothilone D (KOS 862) is an effective microtubule stabilizer. | |||
T10763 | Ceratamine A | Others | |
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent with cytotoxicity against human cancer cell lines. | |||
T75573 | Taccalonolide E | ||
Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis . | |||
T10928 | Cytochalasin A | HIV Protease | |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu... | |||
TN2299 | Vindesine | Others | |
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms. | |||
TQ0112 | Tubulysin A | TubA | Microtubule Associated |
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic. | |||
T75521 | PM050489 | ||
PM050489, a potent polyketone inhibitor of Microtubule/Tubulin isolated from the Madagascan sponge Lithoplocamia lithistoides, effectively inhibits mitosis with an IC 50 value of 26.4 nM. This compound exhibits antitumor... | |||
T72964 | Dictyostatin | Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin | |
Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule-stabilizing and anti-cancer agent that exhibits antiproliferative activity and has potential for tauopathy research. | |||
T74761 | Eleutherobin | ||
Eleutherobin, a potent β-microtubule inhibitor with an IC50 value of 2 μM, exhibits cytotoxic activity against cancer cells at a potency comparable to Paclitaxel. This compound is derived from marine soft coral and is kn... | |||
TN2255 | Taccalonolide AJ | Others | |
Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administr... | |||
T2S1797 | Santalol | Antioxidant , Antifungal | |
1. Santalol has good antibacterial, anti-oxidation and anti-tumor activities. 2. α-Santalol is a potent antimitotic agent induced by interference with microtubule assembly. 3. α-Santalol shows a significant antifungal ef... | |||
T75622 | β-Apopicropodophyllin | ||
β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potentia... | |||
T73206 | Wikstrol A | ||
Wikstrol A, a potent antifungal, antimitotic, and anti-HIV-1 agent, demonstrates significant effects across various biological targets. It induces morphological deformation in P. oryzae mycelia, with a minimum morphologi... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are... | |||
TMPY-03340 | MAP1LC3A Protein, Human, Recombinant (His) | Human | E. coli |
LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between mic... | |||
TMPY-03749 | LC3B Protein, Human, Recombinant (His) | Human | E. coli |
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are in... | |||
TMPJ-00828 | Tau-F Protein, Human, Recombinant | Human | E. coli |
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons... | |||
TMPY-03865 | EB3 Protein, Human, Recombinant (His) | Human | E. coli |
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes t... | |||
TMPJ-00827 | Tau-D Protein, Human, Recombinant (His) | Human | E. coli |
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ... | |||
TMPJ-01321 | MAP1LC3B Protein, Human, Recombinant | Human | E. coli |
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t... | |||
TMPY-04329 | Vimentin Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ... | |||
TMPY-04356 | GSK3B Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ... | |||
TMPH-01254 | DNM1 Protein, Human, Recombinant (His) | Human | E. coli |
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocy... | |||
TMPH-01252 | DCTN1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between sp... | |||
TMPH-02944 | TCTP/TPT1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Involved in calcium binding and microtubule stabilization. | |||
TMPH-02138 | Stathmin-4 Protein, Human, Recombinant (GST) | Human | E. coli |
Exhibits microtubule-destabilizing activity. | |||
TMPJ-01076 | FKBP4 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto... | |||
TMPY-03047 | Stathmin 1 Protein, Human, Recombinant (His) | Human | E. coli |
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and ... | |||
TMPH-01592 | KIF18B Protein, Human, Recombinant (His & Myc) | Human | E. coli |
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. | |||
TMPH-01256 | Dystonin Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc... | |||
TMPH-01257 | Dystonin Protein, Human, Recombinant (His) | Human | Yeast |
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc... | |||
TMPY-04404 | DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST) | Human | Baculovirus-Insect Cells |
DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a... | |||
TMPY-04752 | DCLK1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a... | |||
TMPH-02313 | RPGR Protein, Human, Recombinant (hFc) | Human | HEK293 |
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integ... | |||
TMPH-02304 | Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito... | |||
TMPH-02263 | VASH1 Protein, Human, Recombinant (His) | Human | E. coli |
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito... | |||
TMPH-00895 | Human adenovirus B serotype 3 Hexon protein (His & Myc) | HAdV-3 | E. coli |
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. ... | |||
TMPH-02622 | DOCK8 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a... | |||
TMPH-02262 | TUBB3 Protein, Human, Recombinant (GST) | Human | E. coli |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon... | |||
TMPH-01207 | DOCK8 Protein, Human, Recombinant (His) | Human | Yeast |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a... | |||
TMPY-04025 | CEP57 Protein, Human, Recombinant (GST) | Human | E. coli |
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between... | |||
TMPH-02623 | DOCK8 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a... | |||
TMPH-02444 | Tau Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com... | |||
TMPH-01683 | Tau Protein, Human, Recombinant (HEK293, His) | Human | HEK293 |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com... | |||
TMPH-02443 | Tau Protein, Rhesus macaque, Recombinant (His & SUMO) | Rhesus | E. coli |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com... | |||
TMPH-03229 | Rabies virus (RABV) (strain PM) Phosphoprotein (His) | RABV | E. coli |
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from... | |||
TMPY-02980 | BLOC1S2 Protein, Human, Recombinant (GST) | Human | E. coli |
BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 co... | |||
TMPY-03596 | JTB Protein, Human, Recombinant (mFc) | Human | HEK293 |
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JT... | |||
TMPJ-00015 | GABARAP Protein, Human, Recombinant (His & hFc) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPJ-00016 | GABARAP Protein, Human, Recombinant (GST) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPY-03509 | TCTP/TPT1 Protein, Human, Recombinant (His) | Human | E. coli |
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activi... | |||
TMPY-00994 | MOG Protein, Human, Recombinant (aa 30-149, His) | Human | E. coli |
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only i... | |||
TMPY-02565 | MOG Protein, Mouse, Recombinant (aa 30-149, His) | Mouse | E. coli |
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only i... | |||
TMPY-04023 | BCCIP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-00578 | BCCIP Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-03558 | CDC37 Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is... | |||
TMPY-01715 | CDC37 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is... | |||
TMPY-00909 | S100A1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and a... | |||
TMPH-02846 | BICD2 Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction... | |||
TMPY-03534 | CDC37 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is... | |||
TMPY-00997 | S100A1 Protein, Human, Recombinant | Human | E. coli |
S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and a... | |||
TMPY-02532 | S100A1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and a... | |||
TMPY-02718 | Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST) | Human | E. coli |
DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it... | |||
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Cat No. | Product Name | ||
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L1110 | Microtubule-Targeted Compound Library | 155 compounds | |
A unique collection of 155 microtubule-targeted compounds can be used in HTS and HCS; | |||
L1310 | Cytoskeletal Signaling Pathway Compound Library | 773 compounds | |
A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS; |