microrna

MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.

Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.

Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.

Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC₅₀=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.

1. Pseudoprotodioscin has moderate cytotoxicity.

Cl-amidine hydrochloride is an orally available PAD inhibitor that blocks histone 3 deimination and neutrophil extracellular trap formation and improves survival in septic mice. It induces apoptosis in cancer cells and induces miR-16 to cause cell cycle arrest.

LIN28 inhibitor LI71 is a potent and cell-permeable compound that effectively abolishes LIN28-mediated oligouridylation, with an IC₅₀ of 7 µM (micromolar).

Lin28-let-7a antagonist 1, with an IC₅₀ of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.

PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC₅₀: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity.

TGP-377/421 (Targapre-miR-377/421) is a potent dual inhibitor that binds to and inhibits miR-377 and miR-421 at their functional sites.

Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.

Cy5-MicroRNA Mimic Negative Control is a Cy5-labeled MicroRNA Mimic Negative Control. This compound is a 21-nucleotide miRNA mimic used as a negative control. The sequence of the MicroRNA Mimic Negative Control is designed based on the cel-mir-239b sequence, which is widely utilized as a negative control. It exhibits minimal sequence homology with human, mouse, and rat miRNA.

MicroRNA-21-IN-1 (compound 7A) is an effective inhibitor of microRNA with antiproliferative effects on Hela and HCT-116 cells, showing IC₅₀ values of 5.5 μM and 2.8 μM, respectively. It also induces apoptosis in Hela cells and increases the expression of PTEN, EGR1, and SLIT2, which are functional targets downstream of microRNA-21. This compound holds potential for anticancer research [1].

Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC₅₀: 4 nM), CSF-1R (IC₅₀: 3 nM), Flt-1/3 (IC₅₀: 3/4 nM) and PDGFRβ (IC₅₀: 66 nM). Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).

MicroRNAmodulator-1 (TABLE4 compound 1) is an oxadiazole-class inhibitor of miR-21 with an AC50 of 14.64 μM.

MicroRNAmodulator-2 (TABLE4 compound 2) is a hetero-diazole miR-21 inhibitor with an AC50 of 16.48 μM.

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psoriasis-like skin inflammation by modulating the PI3K/AKT signaling pathway.

Guanosine-5'-triphosphate disodium salt (5'-GTP disodium salt) is an enhancer of myogenic cell differentiation and serves as an energy source for translation and other critical cellular processes.

Lin28 1632 is an inhibitor of RNA binding protein Lin28. It promotes mESC differentiation. Lin281632 is also bromodomain inhibitor.

Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants. It has favorable effects in the improvement of diabetes and regulation of lipid metabolism.

Rubone (2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.

Cl-amidine TFA is an orally active PAD inhibitor with IC₅₀ values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4, respectively. This compound can induce cancer cell apoptosis, and also upregulate the expression of miR-16 (miRNA-16, microRNA-16), thereby triggering cell cycle arrest. In addition, Cl-amidine TFA can block the citrullination of histone 3 and the formation of neutrophil extracellular traps, effectively improving the survival rate of mice with sepsis.