machinery

CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).

GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor disclosed in patent WO 2017066459 A1, and functions by disrupting aminoacyl-tRNA biosynthesis, thereby impairing protein synthesis; GlyRS-IN-1 also suppresses bacterial growth, making it a valuable chemical probe for studying translational machinery, antimicrobial target validation, and the development of novel antibiotics against resistant bacterial pathogens.

CDK2-IN-55 is a potent and highly selective cyclin-dependent kinase 2 (CDK2) inhibitor (IC50 = 15 nM). It disrupts the cell cycle machinery to specifically induce G1/S phase arrest in cancer cells, showing excellent anti-clonogenic and anti-proliferative activities in various gastrointestinal tumor models.

PC58538 is an inhibitor of FtsZ protein, a important role in the division machinery of bacterial cells.

Didesmethylrocaglamide is a and selective small molecule inhibitor of the eukaryotic translation initiation factor 4A (eIF4A) that effectively blocks the protein translation machinery to exert robust anti-proliferative and pro-apoptotic activities against malignant peripheral nerve sheath tumors and various sarcoma lineages.

CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effects.

Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria, such as carbapenem-resistant Acinetobacter baumannii (CRAB), by binding to and inhibiting the protein machinery complex LptB2FGC involved in the transport of outer membrane lipopolysaccharides.

DC271, a retinoid and RAR agonist, mimics the cellular effects of the endogenous ATRA and the synthetic EC23, by binding to retinoid protein machinery such as CRABPII to facilitate the translocation of ATRA into the nucleus [1].

Compound 23, also known as PAN endonuclease-IN-1, demonstrates potent inhibitory activity against PAN endonuclease, a vital element of the influenza virus replication machinery and a significant antiviral target [1]. It exhibits dissociation constants (Kd) of 277 μM, 384 μM, and 328 μM for the wild type (WT), I38T, and E23K variants of PAN endonuclease respectively.

Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu