keratitis

Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.

CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).

RNAIII-inhibiting peptide TFA (RNAIII-inhibiting peptide(TFA))(228544-21-6 free base) inhibits S. aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.

Hexamidine exhibits amoebicidal activity and is applicable in the study of Acanthamoeba keratitis (Acanthamoebakeratitis).

Hexamidine diisethionate is an antimicrobial agent targeting Acanthamoeba protozoa. It shows promise for research into ocular infectious diseases such as Acanthamoeba keratitis.

Vasoactive intestinal peptide is an agonist of VPAC1/VPAC2 receptors (G protein-coupled receptors). In a model of Pseudomonas aeruginosa-induced keratitis, it reduces corneal perforation rates, decreases bacterial load, and inhibits excessive neutrophil infiltration. It enhances anti-inflammatory mediators such as IL-10 and TGF-β while suppressing pro-inflammatory factors like IL-1β and TNF-α, and upregulates lipid mediator-related enzymes (SOCS3, COX-2, ALOX12) to facilitate inflammation resolution. Vasoactive intestinal peptide shows promise for the research of ocular infectious diseases.

Propamidine isethionate is an agent in the diamidine class with potent antibacterial and antiprotozoal properties. It is a critical reagent in the research and treatment of Acanthamoeba keratitis. Propamidine exerts its effects by binding to DNA and interfering with nucleic acid synthesis in pathogens.

Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].

Eprociclovir dihydrate is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Eprociclovir Na is the salt form of Eprociclovir, also known as A-5021, a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Eprociclovir potassium is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a mouse-derived inhibitory antibody that targets mouse 4-1BBL/CD137L and blocks 4-1BB ligand (4-1BBL), thereby inhibiting the activity of CD4+ and CD8+ T cells, and is suitable for research related to cancer, infection, inflammation and immunology, specifically applicable to models such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection, and herpetic stromal keratitis (HSK).

Nucleoside Derivatives - 2',3'-Dideoxy nucleosides; Halo-nucleosides; 5-Modified pyrimidine nucleosides; Drugs and Inhibitors; tracheitis virus test; herpes simplex keratitis drug