ipoic

Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potential chemopreventive and antineoplastic activities, and has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others.

α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.

α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.

α-Lipoic acid-NHS is an alkyl ether-based PROTAC linker used in the synthesis of PROTACs [1].

Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.

(R)-Dihydrolipoic acid is a R-isomer of Dihydrolipoic acid. It is optically active, but only the R-enantiomer is biochemically significant. The lipoic acid/dihydrolipoic acid pair participate in a variety of biochemical transformations.

Alpha-Lipoic Acid Choline Ester is used potentially to treat presbyopia.

α-Lipoic Acid (Thioctic acid) sodium, an essential cofactor for mitochondrial enzyme complexes, functions as an antioxidant. It suppresses NF-κB-dependent activation of HIV-1 LTR [1] [2] [3] and induces ER (endoplasmic reticulum) stress-mediated apoptosis in hepatoma cells [4]. Furthermore, when combined with CPUL1 to form the self-assembled nanoaggregate CPUL1-LA NA, α-Lipoic Acid sodium enhances antitumor efficacy compared to CPUL1 alone [5].

Andrographolide-lipoic acid is an analogue of Andrographolide, synthesized through the conjugation of Andrographolide and Lipoic acid. It inhibits NF-κB and exhibits anti-diabetic effects as well as protective effects on β-cells.