ipoic

Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.

α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.

Andrographolide-lipoic acid is an analogue of Andrographolide, synthesized through the conjugation of Andrographolide and Lipoic acid. It inhibits NF-κB and exhibits anti-diabetic effects as well as protective effects on β-cells.

α-Lipoic Acid (Thioctic acid) sodium, an essential cofactor for mitochondrial enzyme complexes, functions as an antioxidant. It suppresses NF-κB-dependent activation of HIV-1 LTR [1] [2] [3] and induces ER (endoplasmic reticulum) stress-mediated apoptosis in hepatoma cells [4]. Furthermore, when combined with CPUL1 to form the self-assembled nanoaggregate CPUL1-LA NA, α-Lipoic Acid sodium enhances antitumor efficacy compared to CPUL1 alone [5].