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Results for "

inhibitor of mcl1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    13
    TargetMol | Inhibitors_Agonists
s63845
T53461799633-27-4
S63845 is a selective myeloid leukemia 1(MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.
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TargetMol | Inhibitor Hot
AZD-5991 Racemate
AZD5991 Racemate, (Rac)-AZD-5991
T10434L2143010-83-5
AZD-5991 Racemate is the racemate of AZD-5991. (Rac)-AZD-5991 is a novel Mcl-1 inhibitor with IC50 <3 nM in FRET assay and induces upregulation of BCL2,BCL-XL, CMYC and MCL1 in AML cell lines.
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6-8 weeks
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Mcl1-IN-11
T119732042211-13-0
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor with Kis of 0.06 μM and 4.2 μM for Mcl-1 and Bcl-2, respectively.
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6-8 weeks
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Mcl1-IN-12
T119742042211-12-9
Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
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Mcl1-IN-4
T119761580484-04-3
Mcl1-IN-4 is an Mcl1 inhibitor with an IC50 of 0.2 μM.
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6-8 weeks
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Mcl1-IN-9
T119771810769-31-3
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) inhibitor, exhibiting an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
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6-8 weeks
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MIM1
Inhibitor of Mcl-1
T12041509102-00-5
MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.
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Tapotoclax
AMG176, AMG-176
T142131883727-34-1
Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.
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7-10 days
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Mcl1-IN-3
T160291814891-79-6
Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.
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6-8 weeks
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CLZ-8
Mcl1-IN-8, CLZ8, CLZ 8
T16030678158-55-9
CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
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7-10 days
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AZ5576 racemate
T709531333468-05-5
AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
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1-2 weeks
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BRD-810
T89869
BRD-810, a highly selective MCL1 inhibitor, binds to the MCL1 BH3 groove, impeding the sequestration of pro-apoptotic proteins and swiftly triggering caspase activation in MCL1-dependent cell lines. This compound exhibits anti-tumor efficacy in both blood cancer and solid tumor models.
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TC11
CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11
T9083100823-03-8
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
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