idiopathic urticaria

Pidotimod is a synthetic dipeptide with immunomodulatory properties.

Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.

Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.

Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.

Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.

Fexofenadine Impurity F, an impurity present in Fexofenadine, is characterized by its role in the pharmacological profile of this drug. As a H1R antagonist, Fexofenadine serves as an anti-allergic agent, effectively employed in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria [1].

Fexofenadine-D10 hydrochloride is the deuterated form of Fexofenadine (hydrochloride). Fexofenadine hydrochloride (T1470) (MDL-16455 hydrochloride) acts as an H1 receptor antagonist and is employed in studies related to seasonal allergic rhinitis and chronic idiopathic urticaria in individuals over 16 years old.

1-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine is an intermediate in the synthesis of Ebastine. Ebastine is an orally active second-generation antagonist of the histamine H1 receptor. It is utilized in the study of allergic rhinitis symptoms and chronic idiopathic urticaria.