hyaluronidase

Hyaluronidase (Hyaluronate 4-glycanohydrolase), a naturally occurring enzyme, depolymerizes hyaluronic acid through glycosidic bond cleavage and is utilized in ophthalmic surgery.

Hyaluronidase, derived from Streptomyces hyalurolyticus (EC 3.2.1.35), is capable of degrading hyaluronic acid. This enzyme randomly cleaves the β-N-acetylhexosamine-[1→4] glycosidic bonds found in hyaluronic acid, chondroitin, and chondroitin sulfate.

Berahyaluronidase alfa is a recombinant human hyaluronidase that temporarily increases tissue permeability by degrading hyaluronan in the extracellular matrix, thereby facilitating the absorption and dispersion of co-administered subcutaneous drugs like pembrolizumab.

Zinihyaluronidase alfa is an enzyme/recombinant protein related to hyaluronan and can be used for life science research.

Lunularic acid, a dihydrostilbene analog, efficiently inhibits hyaluronidase activity (IC50=0.13 nM) and can be used as an endogenous growth inhibitor in moss plants. Lunularic acid also possesses antioxidant and anti-inflammatory properties, which can be used to study the growth regulation and pharmacological activities of moss plants.

Apigenin 7-O-malonylglucoside (Apigenin 7-O-(6''-O-malonylglucoside)) is found in chrysanthemums and is a flavonoid as well as a glycoside.

L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.

Efgartigimod alfa is an Fc receptor blocker used to treat myasthenia gravis. It reduces overall IgG levels, including the pathogenic acetylcholine receptor (AChR) antibodies found in myasthenia gravis. Additionally, it can be formulated with hyaluronidase.

L-Chicoric Acid (Standard) is a reference standard for research and analysis in studies involving L-Chicoric Acid. L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.

1,2,4,6-Tetra-O-galloyl-β-D-glucose is an antioxidant found in eucalyptus. It exhibits significant superoxide dismutase (SOD)-like antioxidant activity (EC50: 1.55 μM). This compound inhibits tyrosinase (IC50: 0.59 mM) and hyaluronidase (IC50: 0.68 mM). It is applicable in food antioxidants, cosmetic anti-melanogenesis, and anti-allergic/anti-inflammatory research.

Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE derived from electric eels. It shows weak inhibitory activity on human erythrocyte AChE (IC50>100 μM) and has no significant effect on BChE. By inhibiting AChE activity, Monardic acid A decreases acetylcholine breakdown while also inhibiting histamine release and hyaluronidase activity, contributing to its anti-inflammatory and neurotransmitter-regulating properties. It can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus) and is primarily used in the development of anti-inflammatory drugs and treatments for neurodegenerative diseases.

3-Geranyl-4-methoxybenzoic acid exhibits stronger inhibition effect on the activation of hyaluronidase than that of tranilast.

cis-Miyabenol C exhibits antioxidative activities and shows strong hyaluronidase inhibitory effects. cis-Miyabenol C also has ecdysteroid antagonist activity.