heparin

Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in in vivo experiments.

Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt (Sodium heparinate) significantly inhibits exosome-cell interactions.

Heparin Methacrylate (HepMA) is a heparin derivative, modified with methacrylate, making it suitable as a material for tissue engineering scaffolds and as a bioink for 3D printing. Under the influence of the photoinitiator LAP , HepMA self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing inherent support to tissue cells and promoting biodegradation. Its applications include cell culture, bioprinting, and tissue engineering.

Heparin IV-A sodium is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

De-N-sulfated heparin sodium salt is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) is a synthetic polymer which agglutinates red blood cells, and used as a heparin antagonist.

H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is an amino acid sequence in the carboxy-terminal heparin-binding domain of fibronectin that facilitates the assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates.

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is a heparin-binding amino acid sequence located in the carboxy-terminal heparin-binding domain of fibronectin.

Fibronectin Adhesion-promoting Peptide acetate (Heparin Binding Peptide acetate) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.

Heparin disaccharide I-S tetrasodium is a primary disaccharide produced from heparin through the action of heparinases I and II.

Heparin disaccharide I-A (sodium) is a biochemical reagent used in glycoscience research. This field explores the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, the enzymology of glycan formation and degradation, protein-glycan interactions, and the role of glycans in biological systems. It is closely tied to fundamental research, biomedicine, and biotechnology.

Heparin Lithium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII) and enhances its inhibitory effect on coagulation factors, such as thrombin and factor Xa, significantly enhancing anticoagulant activity.

Heparin (Nadroparin) calcium (MW 3600-5000), an anticoagulant, forms a reversible complex with antithrombin III (ATIII), known as the heparin-antithrombin III complex. This complex then irreversibly binds to and inactivates thrombin and other activated clotting factors IX, X, XI, and XII, thereby inhibiting the conversion of fibrinogen to fibrin [1] [2].

Heparin cofactor II precursor fragment [Homo sapiens] is a peptide with the sequence H2N-Tyr-Glu-Ile-Thr-Thr-Ile-His-Asn-Leu-Phe-Arg-OH, MW=1406.58.

Heparin disaccharide IV-H is a biochemical reagent used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It encompasses carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan interactions, and the role of glycans in biological systems. This field is closely linked to basic research, biomedicine, and biotechnology.

Heparin calcium (MW 15000-19000), an anticoagulant, forms a reversible complex with antithrombin III (ATIII), known as the heparin-antithrombin III complex. This complex binds to thrombin and the activated clotting factors IX, X, XI, and XII, leading to their irreversible inactivation and inhibiting the conversion of fibrinogen into fibrin [1] [2].

Heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] is a peptide with the sequence H2N-Phe-Thr-Val-Asp-Arg- Pro-Phe-Leu-Phe-Leu-Ile-Tyr-Glu-His-Arg-OH, MW=1953.25.

Heparinase (Heparinase I) degrades heparin into oligosaccharides or unsaturated disaccharides. It is utilized in the preparation of low molecular weight heparin (LMWH).

Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous thrombosis (jugular vein).Naroparcil enhanced the formation of the thrombin/heparin cofactor II complex, induced dermatophyte sulfate-like substances in plasma from treated rabbits appearance, but reduced the formation of thrombin/antithrombin III complexes in plasma incubated with (125I)-human alpha-thrombin.

L-Cysteine (L-(+)-Cysteine) is a non-essential sulfur-containing amino acid in humans. L-Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main protein in nails, skin, and hair, L-Cysteine is important in collagen production, as well as skin elasticity and texture. Also required in the manufacture of amino acid taurine, L-Cysteine is a component of the antioxidant glutathione, and plays a role in the metabolism of essential biochemicals such as coenzyme A, heparin, and biotin.

Protamine sulfate is a polycationic peptide compound with anti-heparin activity. It can neutralize the anticoagulant effects of heparin, enhance lipid-mediated gene transfer, and is commonly used to establish cystitis models.

1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc.