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Search Results for " hemoglobinuria "

Targets

5

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9189 Iptacopan hydrochloride Iptacopan HCl,LNP023 hydrochloride Complement System
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b...
T76867 Ravulizumab ALXN1210 Complement System
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...
T8509 Danicopan ACH-4471 Complement System
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...
T77190 Crovalimab
Crovalimab (SKY59; RO7112689) is a novel humanized antibody designed to target C5 in a pH-dependent manner, demonstrating binding affinities (KD) of 15.2 nM and 16.8 μM at pH levels of 7.4 and 5.8, respectively. Addition...
T64692 AMY-101 acetate
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02503 CD59a Protein, Mouse, Recombinant (hFc) Mouse HEK293
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 f...
TMPY-02266 CD59a Protein, Mouse, Recombinant (His) Mouse HEK293
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 f...
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