5
2
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9189 | Iptacopan hydrochloride | Iptacopan HCl,LNP023 hydrochloride | Complement System |
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b... | |||
T76867 | Ravulizumab | ALXN1210 | Complement System |
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo... | |||
T8509 | Danicopan | ACH-4471 | Complement System |
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ... | |||
T77190 | Crovalimab | ||
Crovalimab (SKY59; RO7112689) is a novel humanized antibody designed to target C5 in a pH-dependent manner, demonstrating binding affinities (KD) of 15.2 nM and 16.8 μM at pH levels of 7.4 and 5.8, respectively. Addition... | |||
T64692 | AMY-101 acetate | ||
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02503 | CD59a Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 f... | |||
TMPY-02266 | CD59a Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 f... |