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Results for "

gluconeogenesis

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
Biotin
Vitamin H, Vitamin B7, D-Biotin
T111658-85-5
Biotin (Vitamin H) is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
  • $31
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Phanginin A
T730741011528-58-7In house
Phanginin A, a potent and orally active activator of salt-induced kinase 1 (SIK1), effectively inhibits gluconeogenesis, increases the expression of p-SIK1, and decreases the expression of p-CREB. By reducing blood glucose levels and enhancing glucose tolerance and dyslipidemia, Phanginin A holds potential for type 2 diabetes research.
  • $1,270
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Hydrocortisone
Cortisol
T161450-23-7
Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses.
  • $30
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Fosfructose, sodium salt, hydrate (1:3:8)
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8)
T3798481028-91-3
D-Fructose-1,6-bisphosphate sodium salt hydrate is the intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is produced by phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction mediated by fructose-1, 6-diphosphatase-1 is one of the rate-limiting steps of gluconeogenesis. The same reaction occurs in the chloroplasts of plants, D-Fructose-1,6-bisphosphate sodium salt hydrate as part of the reducing pentose phosphate cycle. Since cancer cells use glycolysis as a primary source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.
  • $30
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(R)-3-Hydroxybutanoic acid
T5248625-72-9
3-hydroxybutyric acid is involved in the synthesis and degradation of ketone bodies. Like the other ketone bodies (acetoacetate and acetone), levels of beta-hydroxybutyrate are raised in the blood and urine in ketosis. Beta-hydroxybutyrate is a typical pa
  • $31
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D-Glucose 6-phosphate
Glucose 6-phosphate, G6P
T1926356-73-5
D-Glucose 6-phosphate (G6P) is glucose that hydroxyl group on carbon 6 is phosphorylated by hexose kinase and is involved in glycolysis, gluconeogenesis, and the pentose phosphate pathway, as well as being converted to glycogen or starch storage. G6P serves as a substrate for glucose 6-phosphatase in the liver and hexose 6-phosphate dehydrogenase (H6PDH) in the lumen of the endoplasmic reticulum.
  • $30
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Ingenol 3-monobenzoate
Ingenol 3-benzoaTe
T20064083036-64-0
Ingenol 3-monobenzoate (Ingenol 3-benzoate) acts as an aversive inducing agent. It binds to and activates protein kinase C (PKC) with a Ki of 0.14 nM. This activation inhibits the gene expression of phosphoenolpyruvate carboxykinase, thereby suppressing gluconeogenesis and increasing blood cortisol levels, which results in food aversion.
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3-6 months
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Serpentine
TN499718786-24-8
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet streptozotocin (HFD STZ)-induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.
  • $465
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Regaloside H
TN7038126239-77-8
Regaloside H, a glyceryl phenylpropionate glycoside, is a gluconeogenesis inhibitor.
  • $113
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4,6-Dimethoxysalicylaldehyde
2-Hydroxy-4,6-dimethoxybenzaldehyde
TN9425708-76-9
4,6-Dimethoxysalicylaldehyde inhibits hepatic gluconeogenesis in rat hepatocellular carcinoma cells H4-II-E-C3, which can be used to study type 2 diabetes.
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