fluctuations

Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.

Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.

Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations.

HBT-O is a fluorescent probe used to monitor subtle pH fluctuations in living cells.

Poly(styrenyl acetal trehalose) (pSAT) is synthesized by linking trehalose side chains to a polystyrene backbone through acetal bonds. This compound stabilizes various proteins and enzymes against temperature fluctuations without triggering an innate immune response. Additionally, Poly(styrenyl acetal trehalose) can be utilized in synthesizing protein-polymer conjugates, thereby reducing the renal clearance of active molecules.

GIP (1-30)-Myr, a modified form of GIP (1-30) with Myr, is a fragment of glucose-dependent insulinotropic polypeptide (GIP). This hormone, classified as an incretin, enhances insulin secretion and reduces postprandial blood glucose fluctuations. GIP (1-30) stimulates insulin secretion in a dose-dependent manner, effective within the 10^-9 to 10^-6 M range.