ferrous

Ferrous Bisglycinate (Bisglycine iron(II) salt) is used in the fortification of infant formulations and foods.

Iron(II) fumarate (Iron Fumarate) is the iron(II) salt of fumaric acid, a reddish-orange powder, applied to supply iron intake.

Iron(II) sulfate heptahydrate is an important iron salt commonly used in water treatment as a flocculant, as well as a fertiliser and soil conditioner, and serves as a raw material for the preparation of other iron compounds.

Ferumoxytol (Magnetic Black) is a non-gadolinium based contrast agent for use in magnetic resonance imaging applications.

Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.

Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism.

SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS). SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7(PR)/MDA-MB-231(PR) or KHSRP knockout MCF-7 xenograft mouse models.

AY-4 (Compound AY-4) is a potent PROTAC degrader targeting FTH1, with a dissociation constant (Kd) of 3.17 nM. It effectively increases intracellular ferrous (Fe2+) and ferric (Fe3+) ion levels. AY-4 is a potential anticancer candidate that regulates iron homeostasis through ferritin degradation, enhancing the efficacy of existing drugs. Additionally, AY-4 significantly reduces FTH1 levels in breast cancer cells.

FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels. Furthermore, FINO2 induces widespread lipid peroxidation.

PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.

6-epiforesticine is an alkaloid discovered in Aconitum handelianum that exhibits chelating activity toward ferrous ions (Fe²⁺) (IC₅₀ = 5.04 mg/L) and possesses potential antioxidant effects.

Ferritin is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. Invertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively. The ferritin fou

Bacterial Organophosphorus Medium is used to evaluate the efficiency of phosphorus bacteria in decomposing organophosphorus in phosphorus bacterial fertilizers. It contains glucose, ammonium sulfate, yeast extract, sodium chloride, potassium chloride, magnesium sulfate, ferrous sulfate, manganese sulfate, lecithin, calcium carbonate, and agar.

Bismuth Sulfite Agar Medium is utilized for the selective isolation and cultivation of Salmonella. The composition of Bismuth Sulfite Agar Medium includes tryptone, peptone, beef extract, ferrous sulfate, bismuth sulfite, disodium phosphate, dextrose, brilliant green, and agar.