diosgenin

Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants. It has favorable effects in the improvement of diabetes and regulation of lipid metabolism.

Glyco-diosgenin is an amphiphilic substance steroid detergent widely used for extraction, solubilization, purification and Cryo-EM cryo-electron microscopy of membrane proteins with low critical micelle concentrations.

Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9), a steroidal saponin, is isolated from Paris polyphylla var. yunnanensis, commonly known as Yunnan pine [1].

Diosgenin (Standard) is a reference standard for research and analysis in studies involving Diosgenin. Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants. It has favorable effects in the improvement of diabetes and regulation of lipid metabolism.

Diosgenin glucoside (Standard) is a reference standard for research and analysis in studies involving Diosgenin glucoside. Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.

Diosgenin palmitate (Compound 7) is a steroidal compound found in Dioscorea collettii.

Diosgenin-3-O-β-D-sodium glucuronide is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Diosgenin-3-O-β-D-xylosyl-(1→3)-β-glucoside is a natural product that can be used in related research in the field of life sciences. Its product number is TN8740.

Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.

Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 μg/ml, respectively).

Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells through the mitochondria-related pathway [1].

Antitumor Agent-73, a derivative of Diosgenin, both impedes STAT3 signaling and exogenously stimulates Pdia3/ERp57. This compound demonstrates significant antineoplastic efficacy, exhibiting potency against diverse cancer cell lines that ranges from 7.9 to 341.7 times that of Diosgenin [1].

Yamogenin (Standard) is a reference standard for research and analysis in studies involving Yamogenin. Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.