Home Tools
Log in
Cart

Search Result

Search Results for " destabilizing "

14

Compounds

Cat No. Product Name Synonyms Targets
T74166 Microtubule destabilizing agent-1
Microtubule destabilizing agent-1 (Compound 12b), a hydroxamic acid-based microtubule destabilizing agent (MDA), exhibits potent antitumor activity, favorable metabolic stability, and high bioavailability, making it a pr...
T22661 CHM-1 Apoptosis , Others , Microtubule Associated
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
T6272 Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Apoptosis , Microtubule Associated
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit...
T3S0209 Vincristine ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato...
T13945 Tubulysin Others
Tubulysin family are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, and are potent microtubule destabilizing agents.
T32147 IMC-76 NSC-59276,IMC 76,NSC 59276,NSC59276
IMC-76 is a BCL2 i-motif-interactive compound that can act by destabilizing or unfolding the i-motif.
T34102 Podoverine A
Podoverine A is a microtubule destabilizing natural product from the Podophyllum species.
T24788 Shield-2
Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T27052 CMP3a CMP-3a,CMP 3a
CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destab...
T13937 Tubulysin B Others
Tubulysin B is an agent of potent microtubule destabilizing and highly cytotoxic peptide isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis.
T68686 DAP-81
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50...
T4620 Siramesine Lu 28-179 Sigma receptor
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram...
T71252 PC-046
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti...
T74844 Antiproliferative agent-23
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,...
TargetMol