14
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T74166 | Microtubule destabilizing agent-1 | ||
Microtubule destabilizing agent-1 (Compound 12b), a hydroxamic acid-based microtubule destabilizing agent (MDA), exhibits potent antitumor activity, favorable metabolic stability, and high bioavailability, making it a pr... | |||
T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T6272 | Fosbretabulin Disodium | Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium | Apoptosis , Microtubule Associated |
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit... | |||
T3S0209 | Vincristine | ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR | |
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato... | |||
T13945 | Tubulysin | Others | |
Tubulysin family are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, and are potent microtubule destabilizing agents. | |||
T32147 | IMC-76 | NSC-59276,IMC 76,NSC 59276,NSC59276 | |
IMC-76 is a BCL2 i-motif-interactive compound that can act by destabilizing or unfolding the i-motif. | |||
T34102 | Podoverine A | ||
Podoverine A is a microtubule destabilizing natural product from the Podophyllum species. | |||
T24788 | Shield-2 | ||
Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand. | |||
T27052 | CMP3a | CMP-3a,CMP 3a | |
CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destab... | |||
T13937 | Tubulysin B | Others | |
Tubulysin B is an agent of potent microtubule destabilizing and highly cytotoxic peptide isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. | |||
T68686 | DAP-81 | ||
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50... | |||
T4620 | Siramesine | Lu 28-179 | Sigma receptor |
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram... | |||
T71252 | PC-046 | ||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... | |||
T74844 | Antiproliferative agent-23 | ||
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,... |