deoxythymidine

Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.

L-Lysine, 5'-ester with 3'-azido-3'-deoxythymidine is a bioactive chemical.

Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate essential for DNA synthesis.

Deoxythymidine-5'-triphosphate (dTTP) sodium hydrate, a critical nucleoside triphosphate among the four, functions as a trisodium salt in DNA synthesis [1].

Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate (dTTP) trisodium salt) is one of the four natural deoxynucleotides. It is used for the biosynthesis of deoxyribonucleic acid by DNA polymerase and reverse transcriptase.

3'-Bromo-3'-deoxythymidine is a Nucleoside Derivative - Halo-nucleoside, 2',3'-Dideoxy nucleoside.

4',5'-Didehydro-5'-deoxythymidine is a Nucleoside Derivative - 5'-Modified nucleoside, Didehydro-nucleoside.

5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity as an inhibitor of Mycobacterium tuberculosis monophosphate kinase (TMPKmt), an enzyme essential for DNA replication in Mycobacterium tuberculosis. 5'-Azido-5'-deoxythymidine contains an azide group in its molecular structure, which enhances its ability to inhibit reverse transcriptase, and is commonly used in the study of nucleoside metabolic pathways and related disease mechanisms.

5'-Amino-5'-deoxythymidine is a Nucleoside Derivative - 5'-Deoxy nucleoside; 5'-Modified nucleoside; Amino nucleoside.

3'-N-modified nucleoside; Azido-nucleoside

Nucleoside Derivatives - Halo-nucleosides, 2',3'-Dideoxy nucleosides; Drugs and Inhibitors; Metabolite and related compound B of Zidovudine

2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.

5-deoxy Thymidine (5'-Deoxythymidine) is a thymidine form which 5' position replaced with hydrogen.5'-deoxy Thymidine was effective against the activity of Bacillus subtilis and Staphylococcus aureus.

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.

Alovudine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and is a better biomarker in pancreatic cancer.

2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt is utilized by the enzyme thymidylate synthetase (TS) for the de novo synthesis of dTMP and serves as the reference substrate in studies of dUMP analogues for potential chemotherapy applications.

Thymidine 3',5'-diphosphate tetrasodium (Deoxythymidine 3′,5′-diphosphate tetrasodium) acts as a selective inhibitor targeting staphylococcal nuclease, tudor domain-containing 1 (SND1, a MicroRNA regulatory complex RISC subunit), and [3,5-2H2] tyrosyl nuclease. It possesses anti-tumor properties and serves as a catalyst in various biochemical reactions [1] [2].

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV . AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV . AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway [1] [2] [3] .

Thymidine-5'-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM). It serves as a precursor in the synthesis of α,β-methylene-2'-deoxythymidine 5'-triphosphate, which is a non-cleavable substrate for DNA polymerase.

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

AZT triphosphate sodium, a labeled modified deoxyoligonucleotide (dNTP), releases pyrophosphate to generate fluorescence and is particularly utilized in gene synthesis and sequencing.

GXN20836, also known as 3'-Fluoro-3'-deoxythymidine 5'-monophosphate, is a natural compound identified in Streptomyces albus, Streptomyces lividans, and Streptomyces anthocyanicus, with relevant data acquired.