cucurbitacin a

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin phospho-myosin II co-aggregates by stimulation of the RhoA ROCK pathway and inhibition of LIM-Kinase.

Cucurbitacin A 2-O-β-D-glucopyranoside is a natural product for research related to life sciences. The catalog number is TN5974 and the CAS number is 1135141-76-2.

Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].

25-Deacetylcucurbitacin A, a cucurbitane-type triterpenoid, has potential as an anti-cancer agent and JAK STAT3 signaling pathway inhibitor [1].

Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2 STAT3 with anti-cancer activity.

Cucurbitacin IIa 2-O-glucoside is a natural product for research related to life sciences. The catalog number is TN5995 and the CAS number is 77704-34-8.

Cucurbitacin Q1, a compound isolated from the fruit of Cucumis prophetarum, has been shown to be the pure trans component of cucurbitacin Q.

Cucurbitacin R is a useful organic compound for research related to life sciences and the catalog number is T124655.

Picfeltarraegenin I (Compound 2), a type of cucurbitacin, is derived from Picria fel-terrae Lour [1].

2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate, a cucurbitacin glucoside, can be isolated from the polar fractions of the MeOH extract of Cigarrilla mexicana [1].

Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1 CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplas

2-epi-Cucurbitacin B, a natural product, is derived from Ecballium elaterium L. XVI. [1].

Cucurbitacin V is a natural product for research related to life sciences. The catalog number is TN5990 and the CAS number is 152340-37-9.

11-Oxoisomogroside V (compound 3), a cucurbitacin derived from Luo Han Guo extract, enhances the transcriptional activity of PGC-1α. Luciferase assay data demonstrates that at concentrations of 10 μM and 20 μM, 11-Oxoisomogroside V increases luciferase activity to 133.79% and 143.81%, respectively [1].

Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloar

Hexanorcucurbitacin D, a cucurbitacin, is extractable from the roots of Trichosanthes cucumeroides and is utilized in cardiovascular disease (CVD) research [1].

Cucurbitacin F is a useful organic compound for research related to life sciences. The catalog number is T124590 and the CAS number is 5939-57-1.

Cucurbitacin C is a natural product.

1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2 STAT3.

Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation independent of ERK1 2 activation. Cucurbitacin D, a novel inflammasome activator in macrophages, inhibits HepG2 cell proliferation and induces apoptosis by modulating the JAK STAT3, PI3K Akt mTOR and MAPK signaling pathways, and can be used in the study of cervical cancer, leukemia, and prostate cancer.

Cucurbitacin E-2-O-glucoside (2-β-glucopyranoside) is a triterpene compound derived from the roots of Citrullus colocynthis that inhibits pro-inflammatory cytokines.