cucurbitacin a

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

Cucurbitacin A 2-O-β-D-glucopyranoside is a natural product for research related to life sciences. The catalog number is TN5974 and the CAS number is 1135141-76-2.

Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].

25-Deacetylcucurbitacin A, a cucurbitane-type triterpenoid, has potential as an anti-cancer agent and JAK/STAT3 signaling pathway inhibitor [1].

Cucurbitacin F is a useful organic compound for research related to life sciences. The catalog number is T124590 and the CAS number is 5939-57-1.

Cucurbitacin R is a useful organic compound for research related to life sciences and the catalog number is T124655.

Cucurbitacin I 2-glucoside is a natural product with cytotoxic effects on HSC-T6, Caco-2, and HEPG2 cells.

Cucurbitacin E-2-O-glucoside (2-β-glucopyranoside) is a triterpene compound derived from the roots of Citrullus colocynthis that inhibits pro-inflammatory cytokines.

1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplas

11-Oxoisomogroside V (compound 3), a cucurbitacin derived from Luo Han Guo extract, enhances the transcriptional activity of PGC-1α. Luciferase assay data demonstrates that at concentrations of 10 μM and 20 μM, 11-Oxoisomogroside V increases luciferase activity to 133.79% and 143.81%, respectively [1].

Hexanorcucurbitacin D, a cucurbitacin, is extractable from the roots of Trichosanthes cucumeroides and is utilized in cardiovascular disease (CVD) research [1].

Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation independent of ERK1/2 activation. Cucurbitacin D, a novel inflammasome activator in macrophages, inhibits HepG2 cell proliferation and induces apoptosis by modulating the JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways, and can be used in the study of cervical cancer, leukemia, and prostate cancer.

Cucurbitacin Q1, a compound isolated from the fruit of Cucumis prophetarum, has been shown to be the pure trans component of cucurbitacin Q.

Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloar

Cucurbitacin V is a natural product for research related to life sciences. The catalog number is TN5990 and the CAS number is 152340-37-9.

Cucurbitacin IIa 2-O-glucoside is a natural product for research related to life sciences. The catalog number is TN5995 and the CAS number is 77704-34-8.

Cucurbitacin C is a natural product.

2-epi-Cucurbitacin B, a natural product, is derived from Ecballium elaterium L. XVI. [1].

2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate, a cucurbitacin glucoside, can be isolated from the polar fractions of the MeOH extract of Cigarrilla mexicana [1].

Picfeltarraegenin I (Compound 2), a type of cucurbitacin, is derived from Picria fel-terrae Lour [1].

Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.