crosslinker

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

DTSSP Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

BS2G Crosslinker (disodium) is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

SIA Crosslinker is a non-cleavable ADC linker designed for synthesizing antibody-drug conjugates (ADCs)[1].

SMPH Crosslinker, an alkyl/ether-based PROTAC linker, is utilized for synthesizing PROTACs[1].

UAA crosslinker 1 hydrochloride is an amber codon used to incorporate non-canonical amino acids (ncAAs) into proteins in vivo by leveraging the promiscuous activity of specific wildtype and engineered aminoacyl-tRNA synthetases [1].

UAA crosslinker 1 hydrochloride is an Amber codon-activating agent used for incorporating non-canonical amino acids (ncAAs) into proteins in vivo by leveraging the promiscuous activity of specific wildtype and engineered aminoacyl-tRNA synthetases[1].

BS2G-D4 Deuterated Crosslinker is (Sulfosuccinimidyl) 2,2,4,4-glutarate-D4, is a water-soluble and membrane impermeable protein crosslinking agent.

BS3-D4 Deuterated Crosslinker is (Sulfosuccinimidyl) 2,2,7,7-suberate-D4, is a water-soluble and membrane impermeable protein crosslinking agent.

DSG-D4 Deuterated Crosslinker is[Succinimidyl] 2,2,4,4-glutarate-D4 is a protein crosslinker that is permeable to cell membranes.

DSS-D4 Deuterated Crosslinker is[Succinimidyl] 2,2,7,7-suberate-D4 is a membrane permeable crosslinker with four deuterium atoms.

DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.

BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that makes amino groups react with each other and can be used to synthesize antibody-coupled reactive molecules.

BS3 Crosslinker disodium, a non-cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).

MBS Crosslinker (MBS protein crosslinker) is a crosslinker that can be used as an asymmetric spacer.

DSSeb Crosslinker (Disuccinimidyl sebacate) is a dual N-hydroxyethyl ketone ester and cell-membrane-permeable amine-reactive crosslinker, suitable for protein crosslinking and investigating protein-protein interactions.

Sulfo-SANPAH Crosslinker (Sulfo-SANPAH Cross linker) is a water-soluble isobisfunctional protein crosslinker.

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.

Cyclophosphamide is an alkylating agent type of anti-tumor drug, and its main target is DNA. Cyclophosphamide inhibits the proliferation of tumor cells by undergoing alkylation reactions with DNA, interfering with the replication and transcription processes of DNA.

Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.

Streptozotocin (Streptozocin, NSC-85998) is an antibiotic that enters pancreatic β-cells via the glucose transporter (GLUT2) and induces DNA methylation, leading to β-cell apoptosis. It is toxic to insulin-producing cells and commonly used to establish diabetic animal models. This product is unstable in solution and is recommended to be prepared freshly before use.

Cisplatin (CDDP) is a chemotherapeutic agent with antitumor activity and is a classic DNA crosslinker. It inhibits DNA synthesis and induces DNA damage in cancer cells by forming DNA adducts, ultimately leading to cell death. In addition, Cisplatin can activate ferroptosis and induce autophagy. In animal studies, it is commonly used to establish models of chronic kidney injury and acute renal failure.

Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.