col 3

Chemically modified tetracyclines (CMTs) can inhibit MMPs, but lack antimicrobial activity. Nonantimicrobial derivative of tetracycline called incyclinide (COL-3, CMT-3). Incyclinide (CMT-3) has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture and to inhibit tumor growth and metastasis.

Chloramphenicol 3-O-β-D-glucuronide is a biochemical reagent utilized in glycobiology research. Glycobiology focuses on the structure, synthesis, biology, and evolution of sugars, involving carbohydrate chemistry, glycans' formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to fundamental research, biomedicine, and biotechnology.

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

PEG35000 is a polyethylene glycol with a molecular weight of 35,000, used as a carrier material and modifier in drug delivery systems.

PEG 3350 (Polyethylene glycol 3350) is a PEG polymer with a molecular weight of 3350. It serves as a laxative, thickening agent and solvent, and is extensively utilised in related research within the life sciences sector.

Polyethylene glycol (PEG) is approved by the FDA for use as a carrier or matrix in foods, cosmetics, and pharmaceuticals, including injectable, topical, rectal, and nasal formulations. PEG exhibits minimal toxicity and can be fully excreted from the body via the kidneys (for PEG <30 kDa) or feces (for PEG >20 kDa). It is non-immunogenic, and antibodies to PEG only develop in rabbits when PEG is combined with highly immunogenic proteins.

Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.

1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.

Chelidonine (Standard) is a reference standard for research and analysis in studies involving Chelidonine. 1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.