cav3.2

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.

ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).

Apinocaltamide (ACT-709478) is an orally available and selective T-type calcium channel blocker that penetrates the blood-brain barrier (BBB) with IC50=6.4-18nM for Cav3.1, Cav3.2, and Cav3.3, and is commonly used in epilepsy research.

TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.

L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively).

L-Ascorbic acid (L-Ascorbate) magnesium is an electron donor and an endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid promotes collagen deposition and inhibits elastin production. It also exhibits anticancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells.

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone.

Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC50 values of 1.22 μM for Cav2.2 and 80 μM for Cav3.2, capable of penetrating the central nervous system.

Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.

Cav 3.2 inhibitor 2 is an inhibitor of Cav3.2 T-type Ca2+channels with an IC50=0.09339 μM at a constant potential of -80 mV. Cav 3.2 inhibitor 2 exhibits potent inhibition of T-channel-dependent somatic and visceral pain in mice. inhibitor 2 can be used to study intractable pain.

T-Type calcium channel inhibitor 2 (compound 6g) is a potent inhibitor of the T-type calcium channel, specifically acting on Cav3.1 (α1G) with an IC50 of 31.0 μM, Cav3.2 (α1H) with an IC50 of 83.1 μM, and Cav3.3 (α1I) (α1H). T-Type calcium channel inhibitor 2 exhibited cytotoxicity against A549 and HCT-116 cells with IC50s of 5.0 μM and 6.4 μM, respectively.

Mambalgin 1 TFA, a selective inhibitor of ASIC1a (with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer), preferentially binds to the channel in its closed/inactive state. It demonstrates selectivity for ASIC1a over a range of other channels, including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. In vivo, Mambalgin 1 TFA effectively prolongs the latency of the withdrawal response in mouse tail-flick and paw-flick tests.

Cav 3.2 Inhibitor 4 (Compound 21) is a selective and potent inhibitor of the T-type calcium channel (Ca v 3.2), demonstrating peripheral restriction with an IC50 value of 0.6 μM. It is utilized in atrial fibrillation research [1].

L-Ascorbic acid-d2 is the deuterated form of L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate) acts as an electron donor and is an endogenous antioxidant. It selectively inhibits Cav3.2 channels (Cav3.2 channels) with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid serves as a promoter of collagen deposition and an inhibitor of elastin production.

L-Ascorbic acid-13C-1 is a 13C-labeled version of L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), known as an electron donor, functions as an endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 value of 6.5 μM. Additionally, L-Ascorbic acid acts as a promoter of collagen deposition and an inhibitor of elastin formation.

L-Ascorbic acid-13C-4 is 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate) functions as an electron donor and acts as an endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid promotes collagen deposition and inhibits elastin formation.

L-Ascorbic acid-13C-2 is a 13C-labeled form of L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate) acts as an electron donor and serves as an endogenous antioxidant. It selectively inhibits Cav3.2 channels (Cav3.2 channels) with an IC50 of 6.5 μM and also functions as a promoter of collagen deposition and an inhibitor of elastin production.

L-Ascorbic acid-13C is a 13C-labeled form of L-Ascorbic acid, also known as L-Ascorbate, which acts as an electron donor and an endogenous antioxidant. It selectively inhibits Cav3.2 channels (Cav3.2 channels) with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid functions as a promoter of collagen deposition and an inhibitor of elastin production. It demonstrates anticancer activity by generating reactive oxygen species (ROS) and selectively damaging cancer cells.

Ascorbic acid-13C6 is the 13C labeled compound of Ascorbic acid. Ascorbic acid has a CAS number of 50-81-7. Vitamin C is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen.

L-Ascorbic Acid-13C6 is the 13C labeled compound of L-Ascorbic Acid. L-Ascorbic Acid has a CAS number of 50-81-7. Vitamin C is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen.

L-Ascorbic acid sodium salt (Standard) is the standard substance of L-Ascorbic acid sodium salt, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

L-Ascorbic Acid-13C (Standard) is a reference standard of L-Ascorbic Acid-13C intended for quantitative analysis, quality control, and related biochemical research applications. L-Ascorbic acid-13C is a 13C-labeled form of L-Ascorbic acid, also known as L-Ascorbate, which acts as an electron donor and an endogenous antioxidant. It selectively inhibits Cav3.2 channels (Cav3.2 channels) with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid functions as a promoter of collagen deposition and an inhibitor of elastin production. It demonstrates anticancer activity by generating reactive oxygen species (ROS) and selectively damaging cancer cells.

L-Ascorbic Acid-13C-1 (Standard) is a reference standard of L-Ascorbic Acid-13C-1 intended for quantitative analysis, quality control, and related biochemical research applications. L-Ascorbic acid-13C-1 is a 13C-labeled version of L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), known as an electron donor, functions as an endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 value of 6.5 μM. Additionally, L-Ascorbic acid acts as a promoter of collagen deposition and an inhibitor of elastin formation.